Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Adam J. Ronk"'
Autor:
Adam J. Ronk, Nicole M. Lloyd, Min Zhang, Caroline Atyeo, Hailee R. Perrett, Chad E. Mire, Kathryn M. Hastie, Rogier W. Sanders, Philip J. M. Brouwer, Erica Olmann Saphire, Andrew B. Ward, Thomas G. Ksiazek, Juan Carlos Alvarez Moreno, Harshwardhan M. Thaker, Galit Alter, Sunny Himansu, Andrea Carfi, Alexander Bukreyev
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Lassa virus is a member of the Arenaviridae family, which causes human infections ranging from asymptomatic to severe hemorrhagic disease with a high case fatality rate. We have designed and generated lipid nanoparticle encapsulated, modifie
Externí odkaz:
https://doaj.org/article/4afd193033d54672afc7fc5b00f7b333
Autor:
Rodrigo I. Santos, Philipp A. Ilinykh, Colette A. Pietzsch, Adam J. Ronk, Kai Huang, Natalia A. Kuzmina, Fuchun Zhou, James E. Crowe, Alexander Bukreyev
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113254- (2023)
Summary: Ebola virus (EBOV) and Bundibugyo virus (BDBV) belong to the family Filoviridae and cause a severe disease in humans. We previously isolated a large panel of monoclonal antibodies from B cells of human survivors from the 2007 Uganda BDBV out
Externí odkaz:
https://doaj.org/article/8a1292785f724a3abef3fab20ae45612
Autor:
Matthew R. Chang, Luke Tomasovic, Natalia A. Kuzmina, Adam J. Ronk, Patrick O. Byrne, Rebecca Johnson, Nadia Storm, Eduardo Olmedillas, Yixuan J. Hou, Alexandra Schäfer, Sarah R. Leist, Longping V. Tse, Hanzhong Ke, Christian Coherd, Katrina Nguyen, Maliwan Kamkaew, Anna Honko, Quan Zhu, Galit Alter, Erica Ollmann Saphire, Jason S. McLellan, Anthony Griffiths, Ralph S. Baric, Alexander Bukreyev, Wayne A. Marasco
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
COVID-19 can be treated with monoclonal antibodies against SARS-CoV-2, but emerging new variants might show resistance towards existing therapy. Here authors show that anti-SARS-CoV-2 spike human single-chain antibody fragments could gain neutralizin
Externí odkaz:
https://doaj.org/article/d418ec52ee6b432581629e7a51ee58b4
Autor:
Pauline Maisonnasse, Yoann Aldon, Aurélien Marc, Romain Marlin, Nathalie Dereuddre-Bosquet, Natalia A. Kuzmina, Alec W. Freyn, Jonne L. Snitselaar, Antonio Gonçalves, Tom G. Caniels, Judith A. Burger, Meliawati Poniman, Ilja Bontjer, Virginie Chesnais, Ségolène Diry, Anton Iershov, Adam J. Ronk, Sonia Jangra, Raveen Rathnasinghe, Philip J. M. Brouwer, Tom P. L. Bijl, Jelle van Schooten, Mitch Brinkkemper, Hejun Liu, Meng Yuan, Chad E. Mire, Mariëlle J. van Breemen, Vanessa Contreras, Thibaut Naninck, Julien Lemaître, Nidhal Kahlaoui, Francis Relouzat, Catherine Chapon, Raphaël Ho Tsong Fang, Charlene McDanal, Mary Osei-Twum, Natalie St-Amant, Luc Gagnon, David C. Montefiori, Ian A. Wilson, Eric Ginoux, Godelieve J. de Bree, Adolfo García-Sastre, Michael Schotsaert, Lynda Coughlan, Alexander Bukreyev, Sylvie van der Werf, Jérémie Guedj, Rogier W. Sanders, Marit J. van Gils, Roger Le Grand
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Monoclonal antibodies show great promise in treating Covid-19 patients. Here, Maisonnasse, Aldon and colleagues report pre-clinical results for COVA1-18 and demonstrate that it reduces viral infectivity in three animal models with over 95% efficacy i
Externí odkaz:
https://doaj.org/article/cb63fd675fbc4192b0ac21fa54904b08
Autor:
Delphine C. Malherbe, Drishya Kurup, Christoph Wirblich, Adam J. Ronk, Chad Mire, Natalia Kuzmina, Noor Shaik, Sivakumar Periasamy, Matthew A. Hyde, Julie M. Williams, Pei-Yong Shi, Matthias J. Schnell, Alexander Bukreyev
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-11 (2021)
Abstract The development of effective countermeasures against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the agent responsible for the COVID-19 pandemic, is a priority. We designed and produced ConVac, a replication-competent vesic
Externí odkaz:
https://doaj.org/article/ebf985f490e445e383c6a2b50cb40eb9
Autor:
Anitha D. Jayaprakash, Adam J. Ronk, Abhishek N. Prasad, Michael F. Covington, Kathryn R. Stein, Toni M. Schwarz, Saboor Hekmaty, Karla A. Fenton, Thomas W. Geisbert, Christopher F. Basler, Alexander Bukreyev, Ravi Sachidanandam
Publikováno v:
Viruses, Vol 15, Iss 2, p 350 (2023)
The Marburg and Ebola filoviruses cause a severe, often fatal, disease in humans and nonhuman primates but have only subclinical effects in bats, including Egyptian rousettes, which are a natural reservoir of Marburg virus. A fundamental question is
Externí odkaz:
https://doaj.org/article/f3c460d6f5ec4fc486486a758e4a9e9e
Autor:
Taylor B. Engdahl, Natalia A. Kuzmina, Adam J. Ronk, Chad E. Mire, Matthew A. Hyde, Nurgun Kose, Matthew D. Josleyn, Rachel E. Sutton, Apoorva Mehta, Rachael M. Wolters, Nicole M. Lloyd, Francisca R. Valdivieso, Thomas G. Ksiazek, Jay W. Hooper, Alexander Bukreyev, James E. Crowe, Jr.
Publikováno v:
Cell Reports, Vol 35, Iss 5, Pp 109086- (2021)
Summary: New World hantaviruses (NWHs) are endemic in North and South America and cause hantavirus cardiopulmonary syndrome (HCPS), with a case fatality rate of up to 40%. Knowledge of the natural humoral immune response to NWH infection is limited.
Externí odkaz:
https://doaj.org/article/6188275c140141ab92a3051681cc594b
Autor:
Philip J.M. Brouwer, Aleksandar Antanasijevic, Adam J. Ronk, Helena Müller-Kräuter, Yasunori Watanabe, Mathieu Claireaux, Hailee R. Perrett, Tom P.L. Bijl, Marloes Grobben, Jeffrey C. Umotoy, Angela I. Schriek, Judith A. Burger, Khadija Tejjani, Nicole M. Lloyd, Thijs H. Steijaert, Marlies M. van Haaren, Kwinten Sliepen, Steven W. de Taeye, Marit J. van Gils, Max Crispin, Thomas Strecker, Alexander Bukreyev, Andrew B. Ward, Rogier W. Sanders
Publikováno v:
Cell host & microbe, 30(12), 1759-1772.e12. Cell Press
The Lassa virus is endemic in parts of West Africa, and it causes hemorrhagic fever with high mortality. The development of a recombinant protein vaccine has been hampered by the instability of soluble Lassa virus glycoprotein complex (GPC) trimers,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d35920c6774cfa1a3575acd82410909f
https://eprints.soton.ac.uk/473593/
https://eprints.soton.ac.uk/473593/
Autor:
Philip J.M. Brouwer, Aleksandar Antanasijevic, Adam J. Ronk, Helena Müller-Kräuter, Yasunori Watanabe, Mathieu Claireaux, Nicole M. Lloyd, Tom. P. L. Bijl, Hailee R. Perrett, Thijs Steijaert, Judith A. Burger, Marlies M. van Haaren, Kwinten Sliepen, Marit J. van Gils, Max Crispin, Thomas Strecker, Alexander Bukreyev, Andrew B. Ward, Rogier W. Sanders
Lassa virus is endemic in large parts of West Africa and causes a hemorrhagic fever. Recent years have seen several serious outbreaks of Lassa fever with high mortality rates. A vaccine to curtail infection is urgently needed. The development of a re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::164ec01d4e0b674a597ba94f79c1e342
https://doi.org/10.1101/2022.03.28.486091
https://doi.org/10.1101/2022.03.28.486091
Autor:
Alexander Bukreyev, Natalia Kuzmina, Adam J. Ronk, Matthias J. Schnell, Julie M. Williams, Chad E. Mire, Noor F. Shaik, Sivakumar Periasamy, Drishya Kurup, Christoph Wirblich, Pei Yong Shi, Delphine C. Malherbe, Matthew A. Hyde
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-11 (2021)
NPJ Vaccines
NPJ Vaccines
The development of effective countermeasures against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the agent responsible for the COVID-19 pandemic, is a priority. We designed and produced ConVac, a replication-competent vesicular stom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e33d0d7f27d270062d245d3559900ab6
https://doi.org/10.1101/2021.01.29.428442
https://doi.org/10.1101/2021.01.29.428442