Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Adam J. Roberts"'
Autor:
Adam J. Roberts, Han Boon Ong, Simon Clare, Cordelia Brandt, Katherine Harcourt, Yegnasew Takele, Prakash Ghosh, Angela Toepp, Max Waugh, Daniel Matano, Anna Färnert, Emily Adams, Javier Moreno, Margaret Mbuchi, Christine Petersen, Dinesh Mondal, Pascale Kropf, Gavin J. Wright
Publikováno v:
mBio, Vol 15, Iss 5 (2024)
ABSTRACTVisceral leishmaniasis is a deadly infectious disease and is one of the world’s major neglected health problems. Because the symptoms of infection are similar to other endemic diseases, accurate diagnosis is crucial for appropriate treatmen
Externí odkaz:
https://doaj.org/article/67ae2e30573840219d270dc46cf08f7c
Autor:
Adam J Roberts, Han B Ong, Simon Clare, Cordelia Brandt, Katherine Harcourt, Susanne U Franssen, James A Cotton, Nicole Müller-Sienerth, Gavin J Wright
Publikováno v:
PLoS Pathogens, Vol 18, Iss 2, p e1010364 (2022)
Leishmaniasis is an infectious disease caused by protozoan parasites belonging to the genus Leishmania for which there are no approved human vaccines. Infections localise to different tissues in a species-specific manner with the visceral form of the
Externí odkaz:
https://doaj.org/article/96d36f9863694b608b562da01b02fe21
Autor:
Susan Wyllie, Adam J Roberts, Suzanne Norval, Stephen Patterson, Bernardo J Foth, Matthew Berriman, Kevin D Read, Alan H Fairlamb
Publikováno v:
PLoS Pathogens, Vol 12, Iss 11, p e1005971 (2016)
Drug discovery pipelines for the "neglected diseases" are now heavily populated with nitroheterocyclic compounds. Recently, the bicyclic nitro-compounds (R)-PA-824, DNDI-VL-2098 and delamanid have been identified as potential candidates for the treat
Externí odkaz:
https://doaj.org/article/a48909d39e464a929a528cc874527d3f
Autor:
Helen A Vincent, Jack O Phillips, Charlotte A Henderson, Adam J Roberts, Carlanne M Stone, Charlotte E Mardle, Louise E Butt, Darren M Gowers, Andrew R Pickford, Anastasia J Callaghan
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79142 (2013)
Characterisation of RNA and its intermolecular interactions is increasing in importance as the inventory of known RNA functions continues to expand. RNA-RNA interactions are central to post-transcriptional gene regulation mechanisms in bacteria, and
Externí odkaz:
https://doaj.org/article/50d084be25a9410aace871d7236686ad
Autor:
Gordon J. McDougall, Kei Sakamoto, Benoit Viollet, Calum Forteath, Lisa Logie, Jean Harthill, Amy R. Cameron, Marc Foretz, Kashyap A. Patel, Derek Stewart, Adam J. Roberts, Sandra Bacon, Graham Rena, Calum Sutherland
Publikováno v:
Biochimica et Biophysica Acta
Anti-hyperglycaemic effects of the hydroxybenzoic acid salicylate might stem from effects of the drug on mitochondrial uncoupling, activation of AMP-activated protein kinase, and inhibition of NF-κB signalling. Here, we have gauged the contribution
Autor:
Adam J, Roberts, Alan H, Fairlamb
Publikováno v:
Scientific Reports
Protein N-myristoylation is catalysed by N-myristoyltransferase (NMT), an essential and druggable target in Trypanosoma cruzi, the causative agent of Chagas’ disease. Here we have employed whole cell labelling with azidomyristic acid and click chem