Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Adam J. P. Smith"'
Publikováno v:
npj Climate Action, Vol 2, Iss 1, Pp 1-9 (2023)
Abstract The growing number of scientific publications on climate change has outstripped the capacity of individuals to keep up with the literature, even when confined to selected sub-topics such as chapter sections of IPCC reports. The IPCC would be
Externí odkaz:
https://doaj.org/article/ad409e5999304513a43dae6f479bff66
Autor:
Eric M. Nickels, Shaobo Li, Swe Swe Myint, Katti Arroyo, Qianxi Feng, Kimberly D. Siegmund, Adam J. de Smith, Joseph L. Wiemels
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The role of DNA methylation in predisposing to pediatric acute lymphoblastic leukemia remains unknown. Here, the authors utilize a discordant twin model to investigate how DNA methylation variation contributes to disease risk in genetically identical
Externí odkaz:
https://doaj.org/article/3889c1c5cc274b629ea0d875b109d181
Autor:
Katti Arroyo, Anahit Nargizyan, Francianne G Andrade, Swe Swe Myint, Sabrina Lu, Priyatama Pandey, Amy Yee, Adam J de Smith, Joseph L Wiemels
Publikováno v:
BioTechniques, Vol 72, Iss 4, Pp 121-133 (2022)
DNA methylation is a labile modification associated with gene expression control and environmental adaptations. High throughput, scalable and quantitative assessments of specific DNA methylation modifications in complex genomic regions for use in lar
Externí odkaz:
https://doaj.org/article/2ca2a00484b147d19bc0529fd8b56a68
Autor:
Shaobo Li, Charleston W K Chiang, Swe Swe Myint, Katti Arroyo, Tsz Fung Chan, Libby Morimoto, Catherine Metayer, Adam J de Smith, Kyle M Walsh, Joseph L Wiemels
Publikováno v:
PLoS Genetics, Vol 18, Iss 9, p e1010388 (2022)
BackgroundPilocytic astrocytoma (PA) is the most common pediatric brain tumor. PA has at least a 50% higher incidence in populations of European ancestry compared to other ancestral groups, which may be due in part to genetic differences.MethodsWe fi
Externí odkaz:
https://doaj.org/article/fd422ec2c6d84881bc7daf32d74b12c0
Autor:
Ivo S. Muskens, Shaobo Li, Thomas Jackson, Natalina Elliot, Helen M. Hansen, Swe Swe Myint, Priyatama Pandey, Jeremy M. Schraw, Ritu Roy, Joaquin Anguiano, Katerina Goudevenou, Kimberly D. Siegmund, Philip J. Lupo, Marella F. T. R. de Bruijn, Kyle M. Walsh, Paresh Vyas, Xiaomei Ma, Anindita Roy, Irene Roberts, Joseph L. Wiemels, Adam J. de Smith
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Down syndrome has a high co-morbidity with immune and hematopoietic disorders. Here, the authors perform an epigenome-wide association study in newborns with and without Down syndrome to find differential methylation across the genome, including in h
Externí odkaz:
https://doaj.org/article/638c652373704f3aa4579682f8dc481e
Autor:
Chenan Zhang, Quinn T. Ostrom, Eleanor C. Semmes, Vijay Ramaswamy, Helen M. Hansen, Libby Morimoto, Adam J. de Smith, Melike Pekmezci, Zalman Vaksman, Hakon Hakonarson, Sharon J. Diskin, Catherine Metayer, The Glioma International Case-Control Study (GICC), Michael D. Taylor, Joseph L. Wiemels, Melissa L. Bondy, Kyle M. Walsh
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-12 (2020)
Abstract Ependymoma is the third most common brain tumor in children, with well-described molecular characterization but poorly understood underlying germline risk factors. To investigate whether genetic predisposition to longer telomere length influ
Externí odkaz:
https://doaj.org/article/120d88ccd2ce41e9885174895144abf6
Autor:
Qianxi Feng, Eric Nickels, Ivo S Muskens, Adam J de Smith, W James Gauderman, Amy C Yee, Charite Ricker, Thomas Mack, Andrew D Leavitt, Lucy A Godley, Joseph L Wiemels
Publikováno v:
eLife, Vol 10 (2021)
Background: The role of race/ethnicity in genetic predisposition of early-onset cancers can be estimated by comparing family-based cancer concordance rates among ethnic groups. Methods: We used linked California health registries to evaluate the rela
Externí odkaz:
https://doaj.org/article/eb9c360e1b36468e8eba790ad15f7171
Autor:
Juhi Ojha, Iryna Dyagil, Stuart C. Finch, Robert F. Reiss, Adam J. de Smith, Semira Gonseth, Mi Zhou, Helen M. Hansen, Amy L. Sherborne, Jean Nakamura, Paige M. Bracci, Nataliya Gudzenko, Maureen Hatch, Nataliya Babkina, Mark P. Little, Vadim V. Chumak, Kyle M. Walsh, Dimitry Bazyka, Joseph L. Wiemels, Lydia B. Zablotska
Publikováno v:
Environmental Health, Vol 17, Iss 1, Pp 1-9 (2018)
Abstract Background Chronic lymphocytic leukemia (CLL) was the predominant leukemia in a recent study of Chornobyl cleanup workers from Ukraine exposed to radiation (UR-CLL). Radiation risks of CLL significantly increased with increasing bone marrow
Externí odkaz:
https://doaj.org/article/caa88f5ae5834a5f9044fc8513a0b12f
Autor:
Joseph L. Wiemels, Kyle M. Walsh, Adam J. de Smith, Catherine Metayer, Semira Gonseth, Helen M. Hansen, Stephen S. Francis, Juhi Ojha, Ivan Smirnov, Lisa Barcellos, Xiaorong Xiao, Libby Morimoto, Roberta McKean-Cowdin, Rong Wang, Herbert Yu, Josephine Hoh, Andrew T. DeWan, Xiaomei Ma
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
Childhood acute lymphoblastic leukemia is common in Latino Americans. Here, the authors conduct a genome-wide association study in a Californian cohort containing children of Latino heritage, and identify loci on 17q12 and 8q24 which may affect hemat
Externí odkaz:
https://doaj.org/article/60897a19a3c545a48ff596841e051402
Autor:
Amelia D. Wallace, George A. Wendt, Lisa F. Barcellos, Adam J. de Smith, Kyle M. Walsh, Catherine Metayer, Joseph F. Costello, Joseph L. Wiemels, Stephen S. Francis
Publikováno v:
Frontiers in Genetics, Vol 9 (2018)
Approximately 8% of the human genome is comprised of endogenous retroviral insertions (ERVs) originating from historic retroviral integration into germ cells. The function of ERVs as regulators of gene expression is well established. Less well studie
Externí odkaz:
https://doaj.org/article/cabd8868c0fe42f9a6774612630347ef