Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Adam J. Krieg"'
Publikováno v:
Gynecologic Oncology Reports, Vol 48, Iss , Pp S32-S33 (2023)
Objectives: Using a chemical inhibitor of the SWI/SNF complex (BRM014), we sought to determine if non-cancerous cells harboring wild-type SMARCA4 would spontaneously transform during in vitro culture, thereby providing a new model system for studying
Externí odkaz:
https://doaj.org/article/bd5d835929fc4cf4abe329af542374d2
Autor:
Lei Qiu, Yang Meng, Lingli Wang, Sumedha Gunewardena, Sicheng Liu, Junhong Han, Adam J. Krieg
Publikováno v:
MedComm, Vol 2, Iss 3, Pp 414-429 (2021)
Abstract The hypoxic tumor microenvironment promotes tumor survival by inducing the expression of genes involved in angiogenesis and metastasis. As a direct target of hypoxia‐inducible factor, lysine demethylase 4B (KDM4B) is overexpressed in multi
Externí odkaz:
https://doaj.org/article/26de99bb366f4881b4e3c97134cf7606
Autor:
Eui Jung Moon, Stephano S. Mello, Caiyun G. Li, Jen-Tsan Chi, Kaushik Thakkar, Jacob G. Kirkland, Edward L. Lagory, Ik Jae Lee, Anh N. Diep, Yu Miao, Marjan Rafat, Marta Vilalta, Laura Castellini, Adam J. Krieg, Edward E. Graves, Laura D. Attardi, Amato J. Giaccia
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Hypoxia plays a critical role in tumor progression including invasion and metastasis. Here, the authors screened several hypoxia inducible genes and identified the oncogenic role of MAFF in breast cancer metastasis and that it activates IL11/STAT3 pa
Externí odkaz:
https://doaj.org/article/74a0bdf041f848a69bf653962a2ec1b4
Publikováno v:
Genes, Vol 6, Iss 4, Pp 935-956 (2015)
In the last few decades, epigenetics has emerged as an exciting new field in development and disease, with a more recent focus towards cancer. Epigenetics has classically referred to heritable patterns of gene expression, primarily mediated through D
Externí odkaz:
https://doaj.org/article/5775ed07c7cc4b91b7fce56b96b155d6
Autor:
Cailin Wilson, Adam J. Krieg
Publikováno v:
Genes, Vol 10, Iss 2, p 134 (2019)
Epigenetic changes are well-established contributors to cancer progression and normal developmental processes. The reversible modification of histones plays a central role in regulating the nuclear processes of gene transcription, DNA replication, an
Externí odkaz:
https://doaj.org/article/4ebccd46fade4f5e8d44c767f1f0c4c8
Autor:
Erinn B. Rankin, Katherine C. Fuh, Subarna Sinha, Sarah C. Heilshorn, Adam J. Krieg, Oliver Dorigo, Venkatesh Krishnan, Joshua T. Eggold, Daniel R. Fregoso, Hussein Shehade, Ninna S. Rossen, Michaela I. Soriano, Kaitlyn M. Foreman, Suchitra Natarajan
Supplementary Table S1 shows the list of genes upregulated in metastasis verus matched primary HGSOC. Suppl. to Fig 1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abaff16e71df0fc1f09a70d5358136ca
https://doi.org/10.1158/0008-5472.22422927.v1
https://doi.org/10.1158/0008-5472.22422927.v1
Autor:
Erinn B. Rankin, Katherine C. Fuh, Subarna Sinha, Sarah C. Heilshorn, Adam J. Krieg, Oliver Dorigo, Venkatesh Krishnan, Joshua T. Eggold, Daniel R. Fregoso, Hussein Shehade, Ninna S. Rossen, Michaela I. Soriano, Kaitlyn M. Foreman, Suchitra Natarajan
Peritoneal metastases are the leading cause of morbidity and mortality in high-grade serous ovarian cancer (HGSOC). Accumulating evidence suggests that mesothelial cells are an important component of the metastatic microenvironment in HGSOC. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ddf29167ddf12c9877556800348a6cd9
https://doi.org/10.1158/0008-5472.c.6511374.v1
https://doi.org/10.1158/0008-5472.c.6511374.v1
Autor:
Andrew K. Godwin, Katherine F. Roby, Adam J. Krieg, Devin C. Koestler, Stefan Graw, Thuc Ly, Ziyan Y. Pessetto, Stephen Hyter, Harsh B. Pathak, Jeff Hirst
This document contains supplemental figures 1-17. Figure legends corresponding to each SF are on the subsequent page. Supplemental Figure 1. MCTS formation across a panel of ovarian cancer cell lines. Supplemental Figure 2. The number of proliferatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e28f2c34f81d6d63b85e2cbfd2672d8
https://doi.org/10.1158/0008-5472.22418459.v1
https://doi.org/10.1158/0008-5472.22418459.v1
Autor:
Erinn B. Rankin, Katherine C. Fuh, Subarna Sinha, Sarah C. Heilshorn, Adam J. Krieg, Oliver Dorigo, Venkatesh Krishnan, Joshua T. Eggold, Daniel R. Fregoso, Hussein Shehade, Ninna S. Rossen, Michaela I. Soriano, Kaitlyn M. Foreman, Suchitra Natarajan
Document contains detailed procedures of materials and methods.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bdd117daec139cc2d55f34861c3382d
https://doi.org/10.1158/0008-5472.22424113
https://doi.org/10.1158/0008-5472.22424113
Autor:
Erinn B. Rankin, Katherine C. Fuh, Subarna Sinha, Sarah C. Heilshorn, Adam J. Krieg, Oliver Dorigo, Venkatesh Krishnan, Joshua T. Eggold, Daniel R. Fregoso, Hussein Shehade, Ninna S. Rossen, Michaela I. Soriano, Kaitlyn M. Foreman, Suchitra Natarajan
Figure S1: The omental metastatic microenvironment is hypoxic (suppl. to Fig. 1); Figure S2: Hypoxia preferentially upregulates the expression of enzymes involved in collagen biogenesis and mechanical stability in mesothelial cells (suppl. to Fig. 3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c9b3d0a0b3df8d6000892818c737647
https://doi.org/10.1158/0008-5472.22424116
https://doi.org/10.1158/0008-5472.22424116