Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Adam J. Hume"'
Autor:
Adam J. Hume, Dylan J. Deeney, John S. Smetana, Jacquelyn Turcinovic, John H. Connor, Marlene Belfort, Elke Mühlberger, Christopher W. Lennon
Publikováno v:
mBio, Vol 15, Iss 6 (2024)
ABSTRACT Intervening proteins (inteins) are translated as subdomains within host proteins and removed through an intein-driven splicing reaction where the flanking sequences (exteins) are joined with a peptide bond. Previously, we developed a self-re
Externí odkaz:
https://doaj.org/article/de4e8bdb72b6499c8d080224ab36e8e1
Autor:
Gábor E. Tóth, Adam J. Hume, Ellen L. Suder, Safia Zeghbib, Ágota Ábrahám, Zsófia Lanszki, Zsaklin Varga, Zsófia Tauber, Fanni Földes, Brigitta Zana, Dino Scaravelli, Maria Teresa Scicluna, Andrea Pereswiet-Soltan, Tamás Görföl, Calogero Terregino, Paola De Benedictis, Isabel Garcia-Dorival, Covadonga Alonso, Ferenc Jakab, Elke Mühlberger, Stefania Leopardi, Gábor Kemenesi
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-7 (2023)
Abstract Lloviu cuevavirus (LLOV) was the first identified member of Filoviridae family outside the Ebola and Marburgvirus genera. A massive die-off of Schreibers’s bats (Miniopterus schreibersii) in the Iberian Peninsula in 2002 led to its initial
Externí odkaz:
https://doaj.org/article/117063f0091e464294ee682425844fa2
Autor:
Adam J. Hume, Judith Olejnik, Mitchell R. White, Jessie Huang, Jacquelyn Turcinovic, Baylee Heiden, Pushpinder S. Bawa, Christopher J. Williams, Nickolas G. Gorham, Yuriy O. Alekseyev, John H. Connor, Darrell N. Kotton, Elke Mühlberger
Publikováno v:
Pathogens, Vol 13, Iss 1, p 62 (2024)
Single-cell RNA sequencing (scRNA-seq) technologies are instrumental to improving our understanding of virus–host interactions in cell culture infection studies and complex biological systems because they allow separating the transcriptional signat
Externí odkaz:
https://doaj.org/article/73c0987378d64d07b63bcbae717fefc9
Autor:
Gábor Kemenesi, Gábor E. Tóth, Martin Mayora-Neto, Simon Scott, Nigel Temperton, Edward Wright, Elke Mühlberger, Adam J. Hume, Ellen L. Suder, Brigitta Zana, Sándor A. Boldogh, Tamás Görföl, Péter Estók, Zsófia Lanszki, Balázs A. Somogyi, Ágnes Nagy, Csaba I. Pereszlényi, Gábor Dudás, Fanni Földes, Kornélia Kurucz, Mónika Madai, Safia Zeghbib, Piet Maes, Bert Vanmechelen, Ferenc Jakab
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Lloviu virus (LLOV) is a filovirus that was first identified in 2002 in Schreiber’s bats in Europe. Here, the authors isolate infectious LLOV from Schreiber’s bats in Hungary and show that it can infect human cells in vitro, suggesting potential
Externí odkaz:
https://doaj.org/article/32986f441a644d9ea1543b1895b295fd
Autor:
Judith Olejnik, Adam J. Hume, Stephen J. Ross, Whitney A. Scoon, Scott Seitz, Mitchell R. White, Ben Slutzky, Nadezhda E. Yun, Elke Mühlberger
Publikováno v:
Pathogens, Vol 12, Iss 7, p 952 (2023)
The study of highly pathogenic viruses handled under BSL-4 conditions and classified as Select Agents frequently involves the transfer of inactivated materials to lower containment levels for downstream analyses. Adhering to Select Agent and BSL-4 sa
Externí odkaz:
https://doaj.org/article/c26bcb4efaf34936bdb613d5b61dc334
Autor:
Judith Olejnik, Juliette Leon, Daniel Michelson, Kaitavjeet Chowdhary, Silvia Galvan-Pena, Christophe Benoist, Elke Mühlberger, Adam J. Hume
Publikováno v:
Pathogens, Vol 12, Iss 2, p 342 (2023)
Technologies that facilitate the bulk sequencing of small numbers of cells as well as single-cell RNA sequencing (scRNA-seq) have aided greatly in the study of viruses as these analyses can be used to differentiate responses from infected versus byst
Externí odkaz:
https://doaj.org/article/be575cbc19404d78a405131374231769
Publikováno v:
Microorganisms, Vol 10, Iss 11, p 2110 (2022)
Inteins (intervening proteins) are polypeptides that interrupt the sequence of other proteins and remove themselves through protein splicing. In this intein-catalyzed reaction, the two peptide bonds surrounding the intein are rearranged to release th
Externí odkaz:
https://doaj.org/article/c53b831a44ff4538beb3efecc7273f9e
Autor:
Gábor Kemenesi, Gábor E. Tóth, Martin Mayora-Neto, Simon Scott, Nigel Temperton, Edward Wright, Elke Mühlberger, Adam J. Hume, Ellen L. Suder, Brigitta Zana, Sándor A. Boldogh, Tamás Görföl, Péter Estók, Tamara Szentiványi, Zsófia Lanszki, Balázs A. Somogyi, Ágnes Nagy, Csaba I. Pereszlényi, Gábor Dudás, Fanni Földes, Kornélia Kurucz, Mónika Madai, Safia Zeghbib, Piet Maes, Bert Vanmechelen, Ferenc Jakab
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/ba029dbb68534f918bf27ebf230398bd
Autor:
Stephanie S. Pavlovich, Tamarand Darling, Adam J. Hume, Robert A. Davey, Feng Feng, Elke Mühlberger, Thomas B. Kepler
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Bats host a number of viruses that cause severe disease in humans without experiencing overt symptoms of disease themselves. While the mechanisms underlying this ability to avoid sickness are not known, deep sequencing studies of bat genomes have unc
Externí odkaz:
https://doaj.org/article/9acce80aaeaf45ac9355dc61b1e641ed
Publikováno v:
F1000Research, Vol 8 (2019)
Marburgviruses are closely related to ebolaviruses and cause a devastating disease in humans. In 2012, we published a comprehensive review of the first 45 years of research on marburgviruses and the disease they cause, ranging from molecular biology
Externí odkaz:
https://doaj.org/article/1c12b77a20ad4560be96159803338455