Výsledky vyhledávání - "Adam J. Geach"

Myopalladin, a Novel 145-Kilodalton Sarcomeric Protein with Multiple Roles in Z-Disc and I-Band Protein Assemblies

Autor: Siegfried Labeit, Rob Yamasaki, Ryan E. Mudry, Marie Louise Bang, Henk Granzier, Adam J. Geach, Carol C. Gregorio, Hiroyuki Sorimachi, Karoly Trombitás, Abigail S. McElhinny

Publikováno v: The Journal of Cell Biology

We describe here a novel sarcomeric 145-kD protein, myopalladin, which tethers together the COOH-terminal Src homology 3 domains of nebulin and nebulette with the EF hand motifs of α-actinin in vertebrate Z-lines. Myopalladin's nebulin/nebulette and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cb11ecd1dc170bde384653a81b4fde6
https://doi.org/10.1083/jcb.153.2.413

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The complete gene sequence of titin, expression of an unusual approximately 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system

Autor: Christian Witt, Mark McNabb, Thomas Centner, Siegfried Labeit, Dietmar Labeit, Adam J. Geach, Friderike Fornoff, Carol C. Gregorio, Michael Gotthardt, Marie Louise Bang, Henk Granzier

Publikováno v: Circulation research. 89(11)

Titin is a giant vertebrate striated muscle protein with critical importance for myofibril elasticity and structural integrity. We show here that the complete sequence of the human titin gene contains 363 exons, which together code for 38 138 residue

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6b388de6f817ff90e3101c00f0d4a7a
https://pubmed.ncbi.nlm.nih.gov/11717165

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