Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Adam J Harrington"'
Autor:
Theresa E Bjorness, Ashwinikumar Kulkarni, Volodymyr Rybalchenko, Ayako Suzuki, Catherine Bridges, Adam J Harrington, Christopher W Cowan, Joseph S Takahashi, Genevieve Konopka, Robert W Greene
Publikováno v:
eLife, Vol 9 (2020)
Neuronal activity and gene expression in response to the loss of sleep can provide a window into the enigma of sleep function. Sleep loss is associated with brain differential gene expression, an increase in pyramidal cell mEPSC frequency and amplitu
Externí odkaz:
https://doaj.org/article/1edbd56319244ea8b019e014994d5ab1
Autor:
Adam J Harrington, Aram Raissi, Kacey Rajkovich, Stefano Berto, Jaswinder Kumar, Gemma Molinaro, Jonathan Raduazzo, Yuhong Guo, Kris Loerwald, Genevieve Konopka, Kimberly M Huber, Christopher W Cowan
Publikováno v:
eLife, Vol 5 (2016)
Numerous genetic variants associated with MEF2C are linked to autism, intellectual disability (ID) and schizophrenia (SCZ) – a heterogeneous collection of neurodevelopmental disorders with unclear pathophysiology. MEF2C is highly expressed in devel
Externí odkaz:
https://doaj.org/article/794e5d8051594bd2a413ab1ae3cf6834
Autor:
David B. Everman, Acadia Thielking, Hannah W. Moore, Christopher W. Cowan, Kayla Blankenship, Evgeny Tsvetkov, Adam J Harrington, Catherine Bridges, Genevieve Konopka, Ahlem Assali, Steven A. Skinner, Jennifer Y. Cho, Michael D. Scofield, Benjamin M. Siemsen, Stefano Berto
Publikováno v:
Biol Psychiatry
Background Microdeletions of the MEF2C gene are linked to a syndromic form of autism termed MEF2C haploinsufficiency syndrome (MCHS). MEF2C hypofunction in neurons is presumed to underlie most of the symptoms of MCHS. However, it is unclear in which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a003eafdd732aec6f5f3087afe4b4b95
https://doi.org/10.1016/j.biopsych.2020.03.011
https://doi.org/10.1016/j.biopsych.2020.03.011
Autor:
Nathan McChesney, Jeremy L. Barth, Jeffrey A. Rumschlag, Junying Tan, Adam J. Harrington, Kenyaria V. Noble, Carolyn M. McClaskey, Phillip Elvis, Silvia G. Vaena, Martin J. Romeo, Kelly C. Harris, Christopher W. Cowan, Hainan Lang
Publikováno v:
J Neurosci
Dysfunction of the peripheral auditory nerve (AN) contributes to dynamic changes throughout the central auditory system, resulting in abnormal auditory processing, including hypersensitivity. Altered sound sensitivity is frequently observed in autism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::701aa7dab8c6c507c2f7a1d8feb10a80
https://pubmed.ncbi.nlm.nih.gov/36180228
https://pubmed.ncbi.nlm.nih.gov/36180228
Publikováno v:
Neurobiology of Disease, Vol 37, Iss 2, Pp 330-338 (2010)
VPS41 is a protein identified as a potential therapeutic target for Parkinson's disease (PD) as a result of a high-throughput RNAi screen in Caenorhabditis elegans. VPS41 has a plausible mechanistic link to the pathogenesis of PD, as in yeast it is k
Externí odkaz:
https://doaj.org/article/444f9e35384a4fdf83e30e8fa03d92af
Autor:
Robert W. Greene, Catherine Bridges, Ashwinikumar Kulkarni, Adam J Harrington, Joseph S. Takahashi, Ayako Suzuki, Theresa E. Bjorness, Christopher W. Cowan, Genevieve Konopka, Volodymyr Rybalchenko
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::777694832a0e9ecbe5f66c0d317188f8
https://doi.org/10.7554/elife.58331.sa2
https://doi.org/10.7554/elife.58331.sa2
Autor:
Ashwinikumar Kulkarni, Theresa E. Bjorness, Christopher W. Cowan, Volodymyr Rybalchenko, Genevieve Konopka, Catherine Bridges, Ayako Suzuki, Adam J Harrington, Robert W. Greene, Joseph S. Takahashi
Publikováno v:
eLife, Vol 9 (2020)
eLife
eLife
Neuronal activity and gene expression in response to the loss of sleep can provide a window into the enigma of sleep function. Sleep loss is associated with brain differential gene expression, an increase in pyramidal cell mEPSC frequency and amplitu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a0a11cfff0199250e3b50c055f8df60
https://elifesciences.org/articles/58331
https://elifesciences.org/articles/58331
Autor:
Christopher W. Cowan, Adam J Harrington, Catherine Bridges, Joseph S. Takahashi, Ayako Suzuki, Volodymer Rybalchenko, Theresa E. Bjorness, Robert W. Greene, Ashwinikumar Kulkarni, Genevieve Konopka
Neuronal activity and gene expression in response to the loss of sleep can provide a window into the enigma of sleep function. Sleep loss is associated with brain differential gene expression, an increase in pyramidal cell mEPSC frequency and amplitu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79d78b23729569c69e7c7ec0fde46d3d
https://doi.org/10.1101/2020.04.27.064535
https://doi.org/10.1101/2020.04.27.064535
Autor:
Hannah W. Moore, Christopher W. Cowan, David B. Everman, Acadia Thielking, Adam J Harrington, Genevieve Konopka, Evgeny Tsvetkov, Michael D. Scofield, Stefano Berto, Benjamin M. Siemsen, Kayla Blankenship, Jennifer Y. Cho, Catherine Bridges, Ahlem Assali, Steven A. Skinner
SummaryMicrodeletions of theMEF2Cgene are linked to a syndromic form of autism termedMEF2Chaploinsufficiency syndrome (MCHS). Here, we show that MCHS-associated missense mutations cluster in the conserved DNA binding domain and disrupt MEF2C DNA bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09e2207e9778b86bdfb7d1f04c98313d
https://doi.org/10.1101/824151
https://doi.org/10.1101/824151
Publikováno v:
Curr Opin Neurobiol
The MEF2 family of transcription factors regulates large programs of gene expression important for the development and maintenance of many tissues, including the brain. MEF2 proteins are regulated by neuronal synaptic activity, and they recruit sever
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b5b6b1edc761cc4e56b44bd6e8c9473
https://pubmed.ncbi.nlm.nih.gov/31129473
https://pubmed.ncbi.nlm.nih.gov/31129473