Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Adam J Getzler"'
Publikováno v:
PLoS Biology, Vol 22, Iss 4 (2024)
Externí odkaz:
https://doaj.org/article/d44f996c427243e1ac3135a5dda05ec8
Autor:
Fangming Zhu, Ryan J. McMonigle, Andrew R. Schroeder, Xianyou Xia, David Figge, Braxton D. Greer, Edahí González-Avalos, Diego O. Sialer, Yin-Hu Wang, Kelly M. Chandler, Adam J. Getzler, Emily R. Brown, Changchun Xiao, Olaf Kutsch, Yohsuke Harada, Matthew E. Pipkin, Hui Hu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Follicular helper T (Tfh) cells are essential for germinal center (GC) B cell responses. However, it is not clear which PD-1+CXCR5+Bcl6+CD4+ T cells will differentiate into PD-1hiCXCR5hiBcl6hi GC-Tfh cells and how GC-Tfh cell differentiation
Externí odkaz:
https://doaj.org/article/35c086446d634d7882db802bef9f3af3
Autor:
Adam J. Getzler, Megan A. Frederick, Justin J. Milner, Thomas Venables, Huitian Diao, Clara Toma, Shashank D. Nagaraja, Dominic S. Albao, Simon Bélanger, Shanel M. Tsuda, Jihye Kim, Shane Crotty, Ananda W. Goldrath, Matthew E. Pipkin
Publikováno v:
bioRxiv
CD8+T cells with stem cell-like properties (TSCM) sustain adaptive immunity to intracellular pathogens and tumors. However, the developmental origins and chromatin regulatory factors (CRFs) that establish their differentiation are unclear. Using an R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75d73e585f11a72933734f7f35740eb4
https://doi.org/10.1101/2023.01.18.524461
https://doi.org/10.1101/2023.01.18.524461
Autor:
Chuan Li, Luisa P. Mori, Shuang Lyu, Ronald Bronson, Adam J. Getzler, Matthew E. Pipkin, Susana T. Valente
Publikováno v:
Proceedings of the National Academy of Sciences. 120
HIV gene expression is modulated by the combinatorial activity of the HIV transcriptional activator, Tat, host transcription factors, and chromatin remodeling complexes. To identify host factors regulating HIV transcription, we used specific single-g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a70c77301cc6838e61b6f3ea616e765
https://doi.org/10.1073/pnas.2217476120
https://doi.org/10.1073/pnas.2217476120
The 18S rRNA sequence is highly conserved, particularly at its 3’-end. In contrast, the sequence around the 3’-end is degenerate with similar sites nearby. How RNA is correctly processed by the endonuclease Nob1 is not known, especially because i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c7d028465638d63b9d93165bd2431d9
https://doi.org/10.1101/2022.07.29.501969
https://doi.org/10.1101/2022.07.29.501969
Autor:
Simon Bélanger, Sonya Haupt, Brian L. Freeman, Adam J. Getzler, Huitian Diao, Matthew E. Pipkin, Shane Crotty
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 209(8)
T follicular helper (TFH) cells are a specialized subset of CD4 T cells that deliver critical help signals to B cells for the production of high-affinity Abs. Understanding the genetic program regulating TFH differentiation is critical if one wants t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1b4d33764b7dbbf10729bd04d2dcb54
https://pubmed.ncbi.nlm.nih.gov/36096645
https://pubmed.ncbi.nlm.nih.gov/36096645
Autor:
Jihye Kim, Dapeng Wang, Runqiang Chen, Clara Toma, Huitian Diao, Shane Crotty, Ananda W. Goldrath, Gustavo J. Martinez, Pabalu Karunadharma, Donna M. Martin, J. Justin Milner, Thomas Venables, Shanel Tsuda, Matthew E. Pipkin, Megan A. Frederick, Adam J. Getzler
Individual naive CD8 T cells activated in lymphoid organs differentiate into functionally diverse and anatomically distributed T cell phylogenies in response to intracellular microbes. During infections that resolve rapidly, including live viral vacc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdad561ab24d201361adde2c31ce0001
https://doi.org/10.1101/2021.08.11.456014
https://doi.org/10.1101/2021.08.11.456014
Autor:
Stephen M. Hedrick, Adam J. Getzler, Clara Toma, J. Justin Milner, Miguel Reina-Campos, Jun Qi, Adam Vincek, Bingfei Yu, Shane Crotty, Kyla D. Omilusik, Ming-Ming Zhou, Hongtuyet Nguyen, Nicole E. Scharping, Tomomi M. Yoshida, Anup Dey, Ananda W. Goldrath, Deyao Li, Huitian Diao, Takeshi Egawa, Sara Quon, Arnaud Delpoux, Matthew E. Pipkin, Keiko Ozato
Publikováno v:
The Journal of Experimental Medicine
Journal of Experimental Medicine, vol 218, iss 8
Journal of Experimental Medicine, vol 218, iss 8
BRD4 is a bromodomain-containing protein that binds acetylated histones to regulate transcription. In this issue of JEM, Milner et al. show that BRD4 plays a critical role in the effector function of CD8 T cells responding to infection and cancer.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6981d15438129a849e1363d8752a945
https://doi.org/10.1084/jem.20202512
https://doi.org/10.1084/jem.20202512
Autor:
Ya Chi Ho, Sonia Mediouni, Benoît Lacombe, Luisa Mori, Adam J. Getzler, Katharine M. Jenike, Yang-Hui Jimmy Yeh, Michael D Cameron, Matthew E. Pipkin, Bertha Cecilia Ramirez, Susana T. Valente, Chuan Li
Publikováno v:
Journal of Virology
Journal of Virology, 2020, 95 (4), pp.e01247-20. ⟨10.1128/jvi.01247-20⟩
Journal of Virology, American Society for Microbiology, 2020, 95 (4), pp.e01247-20. ⟨10.1128/jvi.01247-20⟩
J Virol
Journal of Virology, 2020, 95 (4), pp.e01247-20. ⟨10.1128/jvi.01247-20⟩
Journal of Virology, American Society for Microbiology, 2020, 95 (4), pp.e01247-20. ⟨10.1128/jvi.01247-20⟩
J Virol
Human immunodeficiency virus (HIV) transcription requires assembly of cellular transcription factors at the human immunodeficiency virus type 1 (HIV-1) promoter. The TFIIH general transcription factor facilitates transcription initiation by opening t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7ca641e0473ab716f8fd2983139a023
https://doi.org/10.1128/jvi.01247-20
https://doi.org/10.1128/jvi.01247-20
Autor:
Anthony T. Phan, Toan Nguyen, Adam J. Getzler, Dapeng Wang, Shane Crotty, Clara Toma, J. Justin Milner, Matthew E. Pipkin, Kai Zhang, Ananda W. Goldrath, Bingfei Yu, Wei Wang, Kyla D. Omilusik
Publikováno v:
Nature. 552:253-257
Tissue-resident memory CD8+ T (TRM) cells are found at common sites of pathogen exposure, where they elicit rapid and robust protective immune responses. However, the molecular signals that control TRM cell differentiation and homeostasis are not ful
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e80d7e8c904a253d99b5b7b444e1c8e
https://doi.org/10.1038/nature24993
https://doi.org/10.1038/nature24993