Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Adam J Funk"'
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0123158 (2015)
Alterations in GABAergic neurotransmission are implicated in several psychiatric illnesses, including schizophrenia. The Na-K-Cl and K-Cl cotransporters regulate intracellular chloride levels. Abnormalities in cotransporter expression levels could sh
Externí odkaz:
https://doaj.org/article/39aa45d117c84debb00b4818cc44a055
Autor:
Michelle S. Rockwell, PhD, RD, Adam J. Funk, BS, Alison N. Huffstetler, MD, Gabriela Villalobos, MSW, Jacqueline B. Britz, MD, MSPH, Benjamin Webel, BA, Alicia Richards, MS, John W. Epling, MD, MSEd, Roy T. Sabo, PhD, Alex H. Krist, MD, MPH
Publikováno v:
AJPM Focus, Vol 3, Iss 4, Pp 100233- (2024)
Introduction: Unhealthy alcohol use increases the risk for and exacerbation of chronic health conditions. As such, screening, prevention, and management of unhealthy alcohol use is especially critical to improving health outcomes for patients with mu
Externí odkaz:
https://doaj.org/article/bab3584683604536843c6188d38a1272
Autor:
Rawan S. Alnafisah, James Reigle, Mahmoud Ali Eladawi, Sinead M. O’Donovan, Adam J. Funk, Jaroslaw Meller, Robert E. Mccullumsmith, Rammohan Shukla
Publikováno v:
Neuropsychopharmacology. 47:2033-2041
Antipsychotic drugs (APDs) are effective in treating positive symptoms of schizophrenia (SCZ). However, they have a substantial impact on postmortem studies. As most cohorts lack samples from drug-naive patients, many studies, rather than understandi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fbd539274ef7611500d539e19d21e4b
https://doi.org/10.1038/s41386-022-01310-8
https://doi.org/10.1038/s41386-022-01310-8
Autor:
Adam J. Funk, Isaac T. Schiefer, F. S. Hall, Ethel Tackie-Yarboi, James Reigle, Robert E. McCullumsmith, Austin Horton, Tue Q T Chau, Alexander Wisner, Frederick E. Williams
Publikováno v:
ACS Chem Neurosci
Photoaffinity labeling (PAL) remains one of the most widely utilized methods of determining protein targets of drugs. Although useful, the scope of this technique has been limited to in vitro applications because of the inability of UV light to penet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70cfc79da07b8539f9f58456ceb17f94
https://doi.org/10.1021/acschemneuro.0c00416
https://doi.org/10.1021/acschemneuro.0c00416
Autor:
Pauline Janssen, Laurence Ris, Ann Massie, Charles K. Meshul, Olaya Lara, Lutgarde Arckens, Emmanuel Hermans, Robert E. McCullumsmith, Lise Verbruggen, Madeline J Churchill, Hideyo Sato, Noemi Declerck, Adam J. Funk, Cynthia Moore, Sinead M. O’Donovan, Eduard Bentea, Laura De Pauw, Agnès Villers, Erica A K DePasquale
Publikováno v:
Molecular Psychiatry, Vol. 26, no. 9, p. 4754-4769 (2021)
Molecular psychiatry
Molecular psychiatry
The astrocytic cystine/glutamate antiporter system xc− represents an important source of extracellular glutamate in the central nervous system, with potential impact on excitatory neurotransmission. Yet, its function and importance in brain physiol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86f948bd085779f30a8470e3075ba486
https://doi.org/10.1038/s41380-020-0751-3
https://doi.org/10.1038/s41380-020-0751-3
Autor:
Adam J. Funk, Rammohan Shukla, Jaroslaw Meller, Robert E. McCullumsmith, Rawan Alnafisah, Sinead M. O’Donovan, James Reigle
Schizophrenia (SCZ) is a severe and debilitating mental illness. Antipsychotic drugs (APDs) are used to treat both positive and negative SCZ symptoms, by influencing the cellular, subcellular-synaptic, and molecular processes. We posit that these eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f961fc85f6cfe33ae17d1e3d064c469d
https://doi.org/10.1101/2021.10.26.465949
https://doi.org/10.1101/2021.10.26.465949
Autor:
Detlev Boison, Robert E. McCullumsmith, Ryan C Devore Homan, Cassidy Lynn Moody, Adam J. Funk, Sinead M. O’Donovan, Emily Devine
Publikováno v:
Schizophr Bull
The adenosine hypothesis of schizophrenia posits that reduced availability of the neuromodulator adenosine contributes to dysregulation of dopamine and glutamate transmission and the symptoms associated with schizophrenia. It has been proposed that i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d82b74e50ead78a3803dfa234460b60
https://doi.org/10.1093/schbul/sbz086
https://doi.org/10.1093/schbul/sbz086
Autor:
Adam J. Funk, Jaroslaw Meller, Kenneth D. Greis, Rawan Alnafisah, James Reigle, Michael R. Heaven, Behrouz Shamsaei, Rosalinda C. Roberts, Guillaume Labilloy, Robert E. McCullumsmith
The overarching goal of this exploratory study is to link subcellular microdomain specific protein-protein interactomes with big data analytics. We isolated postsynaptic density-95 (PSD-95) complexes from four human brain regions and compared their p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fe30391ab9992f384dba40f7ea87593
https://doi.org/10.1101/2020.05.04.076844
https://doi.org/10.1101/2020.05.04.076844
Autor:
Hunter M. Eby, Rammohan Shukla, Roshanak Asgariroozbehani, Sinead M. O’Donovan, Au-Yeung C, McIntyre Wb, Margaret Hahn, Panda R, Mackenzie E Abel, Adam J. Funk, Xiaolu Zhang, Robert E. McCullumsmith, Lee J, Khaled Alganem, Jarek Meller
BackgroundIn silico data exploration is a key first step of exploring a research question. There are many publicly available databases and tools that offer appealing features to help with such a task. However, many applications lack exposure or are c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bde009cc4441f0f962a19ba091c569b0
https://doi.org/10.1101/2020.05.01.070805
https://doi.org/10.1101/2020.05.01.070805
Autor:
Ruth A. Ross, Adam J. Funk, Emily M. Johansson, Katheron Intson, Marija Milenkovic, Ali Salahpour, Catharine A. Mielnik, Rehnuma Islam, Mary A. Binko, Laurent Groc, Robert E. McCullumsmith, Shreejoy J. Tripathy, Yuxiao Chen, Wendy Horsfall, Amy J. Ramsey, Evelyn K. Lambe, Nirun Sivananthan
Publikováno v:
Molecular Psychiatry
N-methyl-D-aspartate receptors (NMDARs) are required to shape activity-dependent connections in the developing and adult brain. Impaired NMDAR signalling through genetic or environmental insults causes a constellation of neurodevelopmental disorders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2aff042b2ce955e470e899da4f8f8e2
https://pubmed.ncbi.nlm.nih.gov/32807843
https://pubmed.ncbi.nlm.nih.gov/32807843