Zobrazeno 1 - 10
of 156
pro vyhledávání: '"Adam J Dupuy"'
Autor:
Marisa R Buchakjian, Nicole M Merritt, Devon L Moose, Adam J Dupuy, Munir R Tanas, Michael D Henry
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0183469 (2017)
Genetic mouse models of soft tissue sarcoma provide critical insights into disease pathophysiology, which are oftentimes unable to be extracted from human tumor samples or xenograft models. In this study we describe a mouse model of soft tissue sarco
Externí odkaz:
https://doaj.org/article/110cec91e0cb46afa5b7de457cbbbd2d
Autor:
Jesse D Riordan, Vincent W Keng, Barbara R Tschida, Todd E Scheetz, Jason B Bell, Kelly M Podetz-Pedersen, Catherine D Moser, Neal G Copeland, Nancy A Jenkins, Lewis R Roberts, David A Largaespada, Adam J Dupuy
Publikováno v:
PLoS Genetics, Vol 9, Iss 4, p e1003441 (2013)
We previously utilized a Sleeping Beauty (SB) transposon mutagenesis screen to discover novel drivers of HCC. This approach identified recurrent mutations within the Dlk1-Dio3 imprinted domain, indicating that alteration of one or more elements withi
Externí odkaz:
https://doaj.org/article/74ed0ae8a4344f6fbb931f1bfaf4706b
Autor:
Diane DeZwaan-McCabe, Jesse D Riordan, Angela M Arensdorf, Michael S Icardi, Adam J Dupuy, D Thomas Rutkowski
Publikováno v:
PLoS Genetics, Vol 9, Iss 12, p e1003937 (2013)
Viral hepatitis, obesity, and alcoholism all represent major risk factors for hepatocellular carcinoma (HCC). Although these conditions also lead to integrated stress response (ISR) or unfolded protein response (UPR) activation, the extent to which t
Externí odkaz:
https://doaj.org/article/607b8f25d76e47069dd9b7ccf42ab584
Autor:
Maura McGrail, Julia M Hatler, Xianyan Kuang, Hsin-Kai Liao, Kishore Nannapaneni, Kristin E Noack Watt, Juli D Uhl, David A Largaespada, Erik Vollbrecht, Todd E Scheetz, Adam J Dupuy, Jesse M Hostetter, Jeffrey J Essner
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18826 (2011)
Large-scale sequencing of human cancer genomes and mouse transposon-induced tumors has identified a vast number of genes mutated in different cancers. One of the outstanding challenges in this field is to determine which genes, when mutated, contribu
Externí odkaz:
https://doaj.org/article/2527c50033bc4acc9c059bfb44b5c54e
Autor:
Benjamin T Brett, Katherine E Berquam-Vrieze, Kishore Nannapaneni, Jian Huang, Todd E Scheetz, Adam J Dupuy
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24668 (2011)
The recent development of the Sleeping Beauty (SB) system has led to the development of novel mouse models of cancer. Unlike spontaneous models, SB causes cancer through the action of mutagenic transposons that are mobilized in the genomes of somatic
Externí odkaz:
https://doaj.org/article/2eb8ed0a8f8a44d79f655d8cc71c0d51
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107805- (2023)
Summary: Combined BRAF and MEK inhibition is an effective treatment for BRAF-mutant cutaneous melanoma. However, most patients progress on this treatment due to drug resistance. Here, we applied the Sleeping Beauty transposon system to understand how
Externí odkaz:
https://doaj.org/article/307a6faef0774c0fa828d7bf2cb30974
Autor:
Eliot Y. Zhu, Jesse D. Riordan, Marion Vanneste, Michael D. Henry, Christopher S. Stipp, Adam J. Dupuy
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-12 (2022)
Abstract Rare gain-of-function mutations in RAC1 drive drug resistance to targeted BRAF inhibition in cutaneous melanoma. Here, we show that wildtype RAC1 is a critical driver of growth and drug resistance, but only in a subset of melanomas with elev
Externí odkaz:
https://doaj.org/article/e5fe1fcbf15a42ff9db070d5dc09d9f0
Autor:
Eliot Y. Zhu, Adam J. Dupuy
Publikováno v:
BMC Bioinformatics, Vol 23, Iss 1, Pp 1-13 (2022)
Abstract Background The mechanism of action for most cancer drugs is not clear. Large-scale pharmacogenomic cancer cell line datasets offer a rich resource to obtain this knowledge. Here, we present an analysis strategy for revealing biological pathw
Externí odkaz:
https://doaj.org/article/c3ca004b6fd3416888d823ccf81630df
Autor:
Nathan F. Schachter, Jessica R. Adams, Patryk Skowron, Katelyn. J. Kozma, Christian A. Lee, Nandini Raghuram, Joanna Yang, Amanda J. Loch, Wei Wang, Aaron Kucharczuk, Katherine L. Wright, Rita M. Quintana, Yeji An, Daniel Dotzko, Jennifer L. Gorman, Daria Wojtal, Juhi S. Shah, Paul Leon-Gomez, Giovanna Pellecchia, Adam J. Dupuy, Charles M. Perou, Ittai Ben-Porath, Rotem Karni, Eldad Zacksenhaus, Jim R. Woodgett, Susan J. Done, Livia Garzia, A. Sorana Morrissy, Jüri Reimand, Michael D. Taylor, Sean E. Egan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Transposon based screens carried out in mice can identify genes critical for tumourigensis. Here, the authors describe transposon screens in mouse models of breast cancer and highlight a large group of tumour suppressors that could underlie selection
Externí odkaz:
https://doaj.org/article/7b80ad2dd67744ecb57557946c051bff
Autor:
Charlotte R. Feddersen, Lexy S. Wadsworth, Eliot Y. Zhu, Hayley R. Vaughn, Andrew P. Voigt, Jesse D. Riordan, Adam J. Dupuy
Publikováno v:
BMC Genomics, Vol 20, Iss 1, Pp 1-12 (2019)
Abstract Background The introduction of genome-wide shRNA and CRISPR libraries has facilitated cell-based screens to identify loss-of-function mutations associated with a phenotype of interest. Approaches to perform analogous gain-of-function screens
Externí odkaz:
https://doaj.org/article/deb2d1614bf845a88c127a675c0779c0