Zobrazeno 1 - 10
of 206
pro vyhledávání: '"Adam J Dupuy"'
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107805- (2023)
Summary: Combined BRAF and MEK inhibition is an effective treatment for BRAF-mutant cutaneous melanoma. However, most patients progress on this treatment due to drug resistance. Here, we applied the Sleeping Beauty transposon system to understand how
Externí odkaz:
https://doaj.org/article/307a6faef0774c0fa828d7bf2cb30974
Autor:
Eliot Y. Zhu, Jesse D. Riordan, Marion Vanneste, Michael D. Henry, Christopher S. Stipp, Adam J. Dupuy
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-12 (2022)
Abstract Rare gain-of-function mutations in RAC1 drive drug resistance to targeted BRAF inhibition in cutaneous melanoma. Here, we show that wildtype RAC1 is a critical driver of growth and drug resistance, but only in a subset of melanomas with elev
Externí odkaz:
https://doaj.org/article/e5fe1fcbf15a42ff9db070d5dc09d9f0
Autor:
Eliot Y. Zhu, Adam J. Dupuy
Publikováno v:
BMC Bioinformatics, Vol 23, Iss 1, Pp 1-13 (2022)
Abstract Background The mechanism of action for most cancer drugs is not clear. Large-scale pharmacogenomic cancer cell line datasets offer a rich resource to obtain this knowledge. Here, we present an analysis strategy for revealing biological pathw
Externí odkaz:
https://doaj.org/article/c3ca004b6fd3416888d823ccf81630df
Autor:
Nathan F. Schachter, Jessica R. Adams, Patryk Skowron, Katelyn. J. Kozma, Christian A. Lee, Nandini Raghuram, Joanna Yang, Amanda J. Loch, Wei Wang, Aaron Kucharczuk, Katherine L. Wright, Rita M. Quintana, Yeji An, Daniel Dotzko, Jennifer L. Gorman, Daria Wojtal, Juhi S. Shah, Paul Leon-Gomez, Giovanna Pellecchia, Adam J. Dupuy, Charles M. Perou, Ittai Ben-Porath, Rotem Karni, Eldad Zacksenhaus, Jim R. Woodgett, Susan J. Done, Livia Garzia, A. Sorana Morrissy, Jüri Reimand, Michael D. Taylor, Sean E. Egan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Transposon based screens carried out in mice can identify genes critical for tumourigensis. Here, the authors describe transposon screens in mouse models of breast cancer and highlight a large group of tumour suppressors that could underlie selection
Externí odkaz:
https://doaj.org/article/7b80ad2dd67744ecb57557946c051bff
Autor:
Charlotte R. Feddersen, Lexy S. Wadsworth, Eliot Y. Zhu, Hayley R. Vaughn, Andrew P. Voigt, Jesse D. Riordan, Adam J. Dupuy
Publikováno v:
BMC Genomics, Vol 20, Iss 1, Pp 1-12 (2019)
Abstract Background The introduction of genome-wide shRNA and CRISPR libraries has facilitated cell-based screens to identify loss-of-function mutations associated with a phenotype of interest. Approaches to perform analogous gain-of-function screens
Externí odkaz:
https://doaj.org/article/deb2d1614bf845a88c127a675c0779c0
Autor:
Marion Vanneste, Charlotte R. Feddersen, Afshin Varzavand, Elliot Y. Zhu, Tyler Foley, Lei Zhao, Kathleen H. Holt, Mohammed Milhem, Robert Piper, Christopher S. Stipp, Adam J. Dupuy, Michael D. Henry
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Patients with malignant melanoma have a 5-year survival rate of only 15–20% once the tumor has metastasized to distant tissues. While MAP kinase pathway inhibitors (MAPKi) are initially effective for the majority of patients with melanoma harboring
Externí odkaz:
https://doaj.org/article/95a586feb3bf41228e4c027d0dc87c64
Autor:
Safiyyah Ziyad, Jesse D. Riordan, Ann M. Cavanaugh, Trent Su, Gloria E. Hernandez, Georg Hilfenhaus, Marco Morselli, Kristine Huynh, Kevin Wang, Jau-Nian Chen, Adam J. Dupuy, M. Luisa Iruela-Arispe
Publikováno v:
Cell Reports, Vol 22, Iss 5, Pp 1211-1224 (2018)
Summary: Given its role as the source of definitive hematopoietic cells, we sought to determine whether mutations initiated in the hemogenic endothelium would yield hematopoietic abnormalities or malignancies. Here, we find that endothelium-specific
Externí odkaz:
https://doaj.org/article/a74c22f7c9d148fc88f5c03dbb005087
Autor:
Adam J. Rauckhorst, Lawrence R. Gray, Ryan D. Sheldon, Xiaorong Fu, Alvin D. Pewa, Charlotte R. Feddersen, Adam J. Dupuy, Katherine N. Gibson-Corley, James E. Cox, Shawn C. Burgess, Eric B. Taylor
Publikováno v:
Molecular Metabolism, Vol 6, Iss 11, Pp 1468-1479 (2017)
Objective: Excessive hepatic gluconeogenesis is a defining feature of type 2 diabetes (T2D). Most gluconeogenic flux is routed through mitochondria. The mitochondrial pyruvate carrier (MPC) transports pyruvate from the cytosol into the mitochondrial
Externí odkaz:
https://doaj.org/article/b9d97f503bba4483bb4938a821687fc8
All models filtered gCIS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a860e2354f7f2f80a926fa423cb1f59
https://doi.org/10.1158/2326-6066.22542273.v1
https://doi.org/10.1158/2326-6066.22542273.v1
FACS separation of CD4+ and CD8+ T cell subpopulations before sequencing and insertion site analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfa83f0b17abda25a37836823f5cfb0f
https://doi.org/10.1158/2326-6066.22542288
https://doi.org/10.1158/2326-6066.22542288