Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Adam J Dobson"'
Autor:
Adam J Dobson, Susanne Voigt, Luisa Kumpitsch, Lucas Langer, Emmely Voigt, Rita Ibrahim, Damian K Dowling, Klaus Reinhardt
Publikováno v:
PLoS Biology, Vol 21, Iss 8, p e3002218 (2023)
Nutrition is a primary determinant of health, but responses to nutrition vary with genotype. Epistasis between mitochondrial and nuclear genomes may cause some of this variation, but which mitochondrial loci and nutrients participate in complex gene-
Externí odkaz:
https://doaj.org/article/917c5b828f94414397dd0501bb8f4cd3
Autor:
Alessandro Bonfini, Adam J Dobson, David Duneau, Jonathan Revah, Xi Liu, Philip Houtz, Nicolas Buchon
Publikováno v:
eLife, Vol 10 (2021)
The gut is the primary interface between an animal and food, but how it adapts to qualitative dietary variation is poorly defined. We find that the Drosophila midgut plastically resizes following changes in dietary composition. A panel of nutrients c
Externí odkaz:
https://doaj.org/article/e3a13cacf234480291f8284122088071
Autor:
Adam J Dobson, Richard Boulton-McDonald, Lara Houchou, Tatiana Svermova, Ziyu Ren, Jeremie Subrini, Mireya Vazquez-Prada, Mimoza Hoti, Maria Rodriguez-Lopez, Rita Ibrahim, Afroditi Gregoriou, Alexis Gkantiragas, Jürg Bähler, Marina Ezcurra, Nazif Alic
Publikováno v:
PLoS Genetics, Vol 15, Iss 7, p e1008212 (2019)
Ageing populations pose one of the main public health crises of our time. Reprogramming gene expression by altering the activities of sequence-specific transcription factors (TFs) can ameliorate deleterious effects of age. Here we explore how a circu
Externí odkaz:
https://doaj.org/article/d40fec961f234fed9ed5b2f38dc33346
Autor:
Jennifer C Regan, Mobina Khericha, Adam J Dobson, Ekin Bolukbasi, Nattaphong Rattanavirotkul, Linda Partridge
Publikováno v:
eLife, Vol 5 (2016)
Women live on average longer than men but have greater levels of late-life morbidity. We have uncovered a substantial sex difference in the pathology of the aging gut in Drosophila. The intestinal epithelium of the aging female undergoes major deteri
Externí odkaz:
https://doaj.org/article/c0ec6175f0ac431884dc8ed3cd72c0d8
Autor:
Peter David Newell, John M Chaston, Yiping eWang, Nathan J Winans, David eSannino, Adam CN Wong, Adam J Dobson, Jeanne eKagle, Angela Elizabeth Douglas
Publikováno v:
Frontiers in Microbiology, Vol 5 (2014)
Symbiosis is often characterized by co-evolutionary changes in the genomes of the partners involved. An understanding of these changes can provide insight into the nature of the relationship, including the mechanisms that initiate and maintain an ass
Externí odkaz:
https://doaj.org/article/83b623fe630c4850934c7812ba70fac9
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e76521 (2013)
With a diminishing number of effective antibiotics, there has been interest in developing antimicrobial peptides (AMPs) as drugs. However, any new drug faces potential bacterial resistance evolution. Here, we experimentally compare resistance evoluti
Externí odkaz:
https://doaj.org/article/56ae31df7b7a425aadbcacf2bcd2fd23
Autor:
David R. Sannino, Adam J. Dobson
Gut microbiota are fundamentally important for healthy function in their animal hosts. The flyDrosophila melanogasteris a powerful system for understanding the underlying host/microbe interactions, with modulation of the microbiota inducing phenotypi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62e364f45236f0f5231fdd1be7fc081b
https://doi.org/10.1101/2023.01.30.526386
https://doi.org/10.1101/2023.01.30.526386
Autor:
Mirre J.P. Simons, Adam J. Dobson
Ageing research has progressed rapidly through our ability to modulate the ageing process. Pharmacological and dietary treatments can increase lifespan and have been instrumental in our understanding of the mechanisms of ageing. Recently, several stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02bd8c49f40a162f5c8a0fac3e38988c
https://doi.org/10.1101/2022.12.23.521778
https://doi.org/10.1101/2022.12.23.521778
Autor:
Guillermo Martínez Corrales, Mengjia Li, Tatiana Svermova, Alex Goncalves, Diana Voicu, Adam J. Dobson, Tony D. Southall, Nazif Alic
Publikováno v:
Nat Aging
A transient, homeostatic transcriptional response can result in transcriptional memory, programming subsequent transcriptional outputs. Transcriptional memory has great but unappreciated potential to alter animal ageing as animals encounter a multitu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c16d6a9851aabff623283fa66b4d7233
https://europepmc.org/articles/PMC7614430/
https://europepmc.org/articles/PMC7614430/