Výsledky vyhledávání - "Adam J Carlton"

Akademický článek

BAI1 localizes AMPA receptors at the cochlear afferent post-synaptic density and is essential for hearing

Autor: Adam J. Carlton, Jing-Yi Jeng, Fiorella C. Grandi, Francesca De Faveri, Ana E. Amariutei, Lara De Tomasi, Andrew O’Connor, Stuart L. Johnson, David N. Furness, Steve D.M. Brown, Federico Ceriani, Michael R. Bowl, Mirna Mustapha, Walter Marcotti

Publikováno v: Cell Reports, Vol 43, Iss 4, Pp 114025- (2024)

Summary: Type I spiral ganglion neurons (SGNs) convey sound information to the central auditory pathway by forming synapses with inner hair cells (IHCs) in the mammalian cochlea. The molecular mechanisms regulating the formation of the post-synaptic

Externí odkaz: https://doaj.org/article/003f391f46fe499b876a09eda87c4a9d

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Akademický článek

AAV-mediated rescue of Eps8 expression in vivo restores hair-cell function in a mouse model of recessive deafness

Autor: Jing-Yi Jeng, Adam J. Carlton, Richard J. Goodyear, Colbie Chinowsky, Federico Ceriani, Stuart L. Johnson, Tsung-Chang Sung, Yelena Dayn, Guy P. Richardson, Michael R. Bowl, Steve D.M. Brown, Uri Manor, Walter Marcotti

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 26, Iss , Pp 355-370 (2022)

The transduction of acoustic information by hair cells depends upon mechanosensitive stereociliary bundles that project from their apical surface. Mutations or absence of the stereociliary protein EPS8 cause deafness in humans and mice, respectively.

Externí odkaz: https://doaj.org/article/5942f8bc16104f7a85b0dffab23f1f8b

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Akademický článek

Neuroplastin genetically interacts with Cadherin 23 and the encoded isoform Np55 is sufficient for cochlear hair cell function and hearing.

Autor: Sherylanne Newton, Fanbo Kong, Adam J Carlton, Carlos Aguilar, Andrew Parker, Gemma F Codner, Lydia Teboul, Sara Wells, Steve D M Brown, Walter Marcotti, Michael R Bowl

Publikováno v: PLoS Genetics, Vol 18, Iss 1, p e1009937 (2022)

Mammalian hearing involves the mechanoelectrical transduction (MET) of sound-induced fluid waves in the cochlea. Essential to this process are the specialised sensory cochlear cells, the inner (IHCs) and outer hair cells (OHCs). While genetic hearing

Externí odkaz: https://doaj.org/article/43713a3fbece438394f4acc5b108fdae

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MET currents and otoacoustic emissions from mice with a detached tectorial membrane indicate the extracellular matrix regulates Ca 2+ near stereocilia

Autor: Lukas Rüttiger, Stuart L. Johnson, Adam J Carlton, Kevin P. Legan, Jing-Yi Jeng, Philine Marchetta, Guy P. Richardson, Richard J. Goodyear, Laura F. Corns, Csaba Harasztosi, Walter Marcotti

Publikováno v: The Journal of Physiology. 599:2015-2036

Key points The aim was to determine whether detachment of the tectorial membrane (TM) from the organ of Corti in Tecta/Tectb-/- mice affects the biophysical properties of cochlear outer hair cells (OHCs). Tecta/Tectb-/- mice have highly elevated hear

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0d15f54f9c4900b80472ef820361d2d9
https://doi.org/10.1113/jp280905

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Neuroplastin genetically interacts with Cadherin 23 and the encoded isoform Np55 is sufficient for cochlear hair cell function and hearing

Autor: Carlos A. Aguilar, Michael R. Bowl, Adam J Carlton, Steve D.M. Brown, Sara Wells, Fanbo Kong, Lydia Teboul, Andrew Parker, Walter Marcotti, Gemma F. Codner, Sherylanne Newton

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c795668b4d8afabbb61948f4053eca76
https://doi.org/10.1101/2021.11.10.468016

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MET currents and otoacoustic emissions from mice with a detached tectorial membrane indicate the extracellular matrix regulates Ca

Autor: Jing-Yi, Jeng, Csaba, Harasztosi, Adam J, Carlton, Laura F, Corns, Philine, Marchetta, Stuart L, Johnson, Richard J, Goodyear, Kevin P, Legan, Lukas, Rüttiger, Guy P, Richardson, Walter, Marcotti

Publikováno v: J Physiol

The tectorial membrane (TM) is an acellular structure of the cochlea that is attached to the stereociliary bundles of the outer hair cells (OHCs), electro-motile cells that amplify motion of the cochlear partition and sharpen its frequency selectivit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5b93afcadf27482a13b0bbb9a84bf7d7
https://pubmed.ncbi.nlm.nih.gov/33559882

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Autor: David N. Furness, Stuart L. Johnson, Mirna Mustapha, Sara Wells, Michael R. Bowl, Adam J Carlton, Jing-Yi Jeng, Walter Marcotti, Lara De Tomasi, Matthew C. Holley, Francesca De Faveri, Steve D. M. Brown, Richard J. Goodyear, Guy P. Richardson

Publikováno v: J Physiol

KEY POINTS: Age-related hearing loss (ARHL) is a very heterogeneous disease, resulting from cellular senescence, genetic predisposition and environmental factors (e.g. noise exposure). Currently, we know very little about age-related changes occurrin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7346221ac5c690cdec1f8d2991c3bc5f
https://eprints.keele.ac.uk/9605/1/JP279795.pdf

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Biophysical and morphological changes in inner hair cells and their efferent innervation in the ageing mouse cochlea

Autor: Adam J Carlton, Stuart L. Johnson, Michael R. Bowl, Matthew C. Holley, Walter Marcotti, Steve D.M. Brown, Jing-Yi Jeng

Publikováno v: J Physiol

Key points Age-related hearing loss is a progressive hearing loss involving environmental and genetic factors, leading to a decrease in hearing sensitivity, threshold and speech discrimination. We compared age-related changes in inner hair cells (IHC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41374de299d1a5dfded1b5f0d51234fa
https://pubmed.ncbi.nlm.nih.gov/33179774

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