Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Adam J Bittel"'
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108632- (2024)
Summary: Endurance exercise training is beneficial for skeletal muscle health, but it is unclear if this type of exercise can target or correct the molecular mechanisms of facioscapulohumeral muscular dystrophy (FSHD). Using the FLExDUX4 murine model
Externí odkaz:
https://doaj.org/article/4630d63d1e03418f9dfbcda9da3a3b78
Autor:
Kathryn L. Bohnert, Grace Ditzenberger, Adam J. Bittel, Lisa de lasFuentes, Manuela Corti, Christina A. Pacak, Carolyn Taylor, Barry J. Byrne, Dominic N. Reeds, W. Todd Cade
Publikováno v:
JIMD Reports, Vol 62, Iss 1, Pp 74-84 (2021)
Abstract Background Muscle weakness and exercise intolerance contribute to reduced quality of life (QOL) in Barth syndrome (BTHS). Our group previously found that 12 weeks of resistance exercise training (RET) improved muscle strength, however, did n
Externí odkaz:
https://doaj.org/article/bda2cf0580534a32a6f3a6972555f1cf
Autor:
W. Todd Cade, Kathryn L. Bohnert, Adam J. Bittel, Shaji J. Chacko, Bruce W. Patterson, Christina A. Pacak, Barry J. Byrne, Hilary J. Vernon, Dominic N. Reeds
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 25, Iss , Pp 100675- (2020)
Barth syndrome (BTHS) is a rare, X-linked cardiomyopathy that is characterized by abnormalities in glucose and lipid metabolism, with less known regarding amino acid metabolism. This pilot study characterized whole-body arginine kinetics and found lo
Externí odkaz:
https://doaj.org/article/925992a8f07247c387572895a3a12948
Publikováno v:
Journal of Personalized Medicine; Volume 13; Issue 7; Pages: 1040
Facioscapulohumeral muscular dystrophy (FSHD) is caused by the aberrant expression of the double homeobox 4 (DUX4) gene. The FLExDUX4 mouse model carries an inverted human DUX4 transgene which has leaky DUX4 transgene expression at a very low level.
Autor:
Grace Ditzenberger, Barry J. Byrne, W. Todd Cade, Kathryn L. Bohnert, Carolyn L. Taylor, Adam J. Bittel, Dominic N. Reeds, Manuela Corti, Christina A. Pacak, Lisa de las Fuentes
Publikováno v:
JIMD Reports, Vol 62, Iss 1, Pp 74-84 (2021)
JIMD Reports
JIMD Reports
Background Muscle weakness and exercise intolerance contribute to reduced quality of life (QOL) in Barth syndrome (BTHS). Our group previously found that 12 weeks of resistance exercise training (RET) improved muscle strength, however, did not increa
Proteomic studies in facioscapulohumeral muscular dystrophy (FSHD) could offer new insight to disease mechanisms underpinned by post-transcriptional processes. We used stable isotope (deuterium oxide; D2O) labelling and peptide mass spectrometry to i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97606728f9240c678489727a6eec544f
https://doi.org/10.1101/2022.12.14.520394
https://doi.org/10.1101/2022.12.14.520394
Autor:
Adam J. Bittel, Sen Chandra Sreetama, Daniel C. Bittel, Adam Horn, James S. Novak, Toshifumi Yokota, Aiping Zhang, Rika Maruyama, Kenji Rowel Q. Lim, Jyoti K. Jaiswal, Yi-Wen Chen
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 15, p 5575 (2020)
Deficits in plasma membrane repair have been identified in dysferlinopathy and Duchenne Muscular Dystrophy, and contribute to progressive myopathy. Although Facioscapulohumeral Muscular Dystrophy (FSHD) shares clinicopathological features with these
Externí odkaz:
https://doaj.org/article/46253f1ec51248d590ae5b3a75b5c205
Autor:
William Todd Cade, Kathryn L Bohnert, Dominic N Reeds, Linda R Peterson, Adam J Bittel, Adil Bashir, Barry J Byrne, Carolyn L Taylor
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197776 (2018)
Barth syndrome (BTHS) is an ultra-rare, X-linked recessive disorder characterized by cardio-skeletal myopathy, exercise intolerance, and growth delay. Oxygen uptake during peak exercise (VO2peak) has been shown to be severely limited in individuals w
Externí odkaz:
https://doaj.org/article/e6bd78e1d7b5463dbc29a12fa8909885
Publikováno v:
Diabetes
Two-thirds of people with type 2 diabetes mellitus (T2DM) have or will develop chronic kidney disease (CKD), which is characterized by rapid renal decline that, together with superimposed T2DM-related metabolic sequelae, synergistically promotes earl
Autor:
Mihoko Yoshino, Jun Yoshino, Gordon I. Smith, Richard I. Stein, Adam J. Bittel, Daniel C. Bittel, Dominic N. Reeds, David R. Sinacore, W. Todd Cade, Bruce W. Patterson, Kevin Cho, Gary J. Patti, Bettina Mittendorfer, Samuel Klein
Publikováno v:
Cell metabolism. 34(10)
Lifestyle therapy (energy restriction and exercise) is the cornerstone of therapy for people with type 2 diabetes (T2D) but is difficult to implement. We conducted an 8-month randomized controlled trial in persons with obesity and T2D (17 women and 1