Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Adam J, Simon"'
Autor:
Adam J. Simon, David M. Devilbiss, Emily Dunn, Mayuresh V. Kothare, Stephen J. Martino, Jena L. Etnoyer-Slaski, Christopher R. Dussourd
Publikováno v:
Journal of Healthcare Engineering
Journal of Healthcare Engineering, Vol 2019 (2019)
Journal of Healthcare Engineering, Vol 2019 (2019)
A variety of cognitive assessment tools are used to determine the functional status of the brain before and after injury in athletes. Questionnaires, neuropsychological tests, and electroencephalographic (EEG) measures have been recently used to dire
Autor:
Daniel J. Holder, Jeffrey L. Seeburger, C Joachim, Mary J. Savage, A. David Smith, Marc Combrinck, Vijay Modur, Karen Snyder, William Z. Potter, Michael Tanen, Derek L Chappell, Adam J. Simon, Omar F Laterza, Mary Flynn, Gordon K. Wilcock, Aimee Dallob
Publikováno v:
Journal of Alzheimer's Disease. 44:525-539
Cerebrospinal fluid (CSF) amyloid-β (Aβ) and tau have been studied as markers of Alzheimer's disease (AD). Combined Aβ42 and t-tau distinguishes AD from healthy controls with a sensitivity and specificity (sens/spec) near 89% across studies. This
Publikováno v:
Alzheimer Disease & Associated Disorders. 27:233-243
Previous studies that have examined the potential for plasma markers to serve as biomarkers for Alzheimer disease (AD) have studied single analytes and focused on the amyloid-β and τ isoforms and have failed to yield conclusive results. In this stu
Autor:
Hashem Ashrafiuon, Parham Ghorbanian, Terry Hess, David M. Devilbiss, Ajay Verma, Allan L. Bernstein, Adam J. Simon
Publikováno v:
Annals of Biomedical Engineering. 41:1243-1257
Alzheimer's disease (AD) is associated with deficits in a number of cognitive processes and executive functions. Moreover, abnormalities in the electroencephalogram (EEG) power spectrum develop with the progression of AD. These features have been tra
Autor:
Charlotte E. Teunissen, Marcel M. Verbeek, Robert M. Umek, Henrik Zetterberg, Maria C. Carrillo, Theresa Heath, Andreas Jeromin, Holly Soares, Marianne Ratcliffe, Ingrid Zegers, Ulf Andreasson, June Kaplow, Adam J. Simon, Josef Pannee, Niklas Mattsson, Rand Jenkins, Andrew Lockhart, Leslie M. Shaw, Marinus A. Blankenstein, Michael P. Lunn, Hugo Vanderstichele, Robert L. Martone, Omar F Laterza, Robert Bowser, Johan Gobom, Kevin Mills, Kaj Blennow, Erik Portelius, Daniel Kidd, Maria Bjerke
Publikováno v:
Mattsson, N, Zegers, I, Andreasson, U, Bjerke, M, Blankenstein, M A, Bowser, R, Carrillo, M C, Gobom, J, Heath, T, Jenkins, R, Jeromin, A, Kaplow, J, Kidd, D, Laterza, O F, Lockhart, A, Lunn, M P, Martone, R L, Mills, K, Pannee, J, Ratcliffe, M, Shaw, L M, Simon, A J, Soares, H, Teunissen, C E, Verbeek, M M, Umek, R M, Vanderstichele, H, Zetterberg, H, Blennow, K & Portelius, E 2012, ' Reference measurement procedures for Alzheimer's disease cerebrospinal fluid biomarkers: definitions and approaches with focus on amyloid beta 42 ', Biomarkers in medicine, vol. 6, no. 4, pp. 409-417 . https://doi.org/10.2217/BMM.12.39
Biomarkers in Medicine, 6, 409-17
Biomarkers in Medicine, 6, 4, pp. 409-17
Biomarkers in medicine, 6(4), 409-417. Future Medicine Ltd.
Biomarkers in Medicine, 6, 409-17
Biomarkers in Medicine, 6, 4, pp. 409-17
Biomarkers in medicine, 6(4), 409-417. Future Medicine Ltd.
Item does not contain fulltext Cerebrospinal fluid (CSF) biomarkers for Alzheimer's disease (AD) are increasingly used in clinical settings, research and drug trials. However, their broad-scale use on different technology platforms is hampered by the
Autor:
Eric A. Price, Adam J. Simon, Jennifer S. Shapiro, Sethu Sankaranarayanan, Mark Stiteler, Guoxin Wu
Publikováno v:
Journal of Neuroscience Methods. 205:36-44
Cerebrospinal fluid (CSF) provides a window into central nervous system (CNS) physiology and pathophysiology in human neurodegenerative conditions such as Alzheimer's disease. Changes in CSF bioanalytes also provide a direct readout of target engagem
Publikováno v:
Journal of Neuroscience Research. 89:822-832
Amyloid-β peptide (Aβ) is generated by sequential cleavage of the amyloid precursor protein (APP) by β-site amyloid precursor protein cleaving enzyme 1 (β-secretase, or BACE1) and γ-secretase. Several reports demonstrate increased BACE1 enzymati
Autor:
Annika Öhrfelt, Daniel J. Holder, Ulf Andreasson, Adam J. Simon, Viswanath Devanarayan, Henrik Zetterberg, William Z. Potter, Åke Edman, Jeffrey L. Seeburger, A. David Smith, Kaj Blennow, Anders Wallin
Publikováno v:
Dementia and Geriatric Cognitive Disorders EXTRA
Dementia and Geriatric Cognitive Disorders Extra, Vol 1, Iss 1, Pp 31-42 (2011)
Dementia and Geriatric Cognitive Disorders Extra, Vol 1, Iss 1, Pp 31-42 (2011)
Background: Novel biomarkers are important for identifying as well as differentiating subcortical vascular dementia (SVD) and Alzheimer’s disease (AD) at an early stage in the disease process. Methods: In two independent cohorts, a multiplex immuno
Autor:
Eric A. Price, Gene G. Kinney, Randall J. Bateman, Maria S. Michener, Marie A. Holahan, Parker Mathers, Adam J. Simon, Kristin R. Wildsmith, Guoxin Wu, David B. Gilberto, Kevin E. Yarasheski, Mark S. Shearman, Jennifer X. Wang, Jacquelynn J. Cook
Publikováno v:
The Journal of Neuroscience. 30:6743-6750
The accumulation of amyloid β (Aβ) in Alzheimer's disease is caused by an imbalance of production and clearance, which leads to increased soluble Aβ species and extracellular plaque formation in the brain. Multiple Aβ-lowering therapies are curre
Autor:
Christopher M. Clark, Robert A. Dean, Ronald C. Petersen, Adam J. Simon, Kaj Blennow, William J. Jagust, Paul S. Aisen, John Q. Trojanowski, Eric Siemers, Michael W. Weiner, Magdalena Korecka, Piotr Lewczuk, Virginia M.-Y. Lee, Clifford R. Jack, William Z. Potter, Holly Soares, Arthur W. Toga, Leslie M. Shaw, Hugo Vandeerstichele
Publikováno v:
Alzheimer's & Dementia. 6:230-238
Here, we review progress by the Penn Biomarker Core in the Alzheimer's Disease Neuroimaging Initiative (ADNI) toward developing a pathological cerebrospinal fluid (CSF) and plasma biomarker signature for mild Alzheimer's disease (AD) as well as a bio