Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Adam J, Ruben"'
Autor:
Andrew S, Ishizuka, Kirsten E, Lyke, Adam, DeZure, Andrea A, Berry, Thomas L, Richie, Floreliz H, Mendoza, Mary E, Enama, Ingelise J, Gordon, Lee-Jah, Chang, Uzma N, Sarwar, Kathryn L, Zephir, LaSonji A, Holman, Eric R, James, Peter F, Billingsley, Anusha, Gunasekera, Sumana, Chakravarty, Anita, Manoj, MingLin, Li, Adam J, Ruben, Tao, Li, Abraham G, Eappen, Richard E, Stafford, Natasha, K C, Tooba, Murshedkar, Hope, DeCederfelt, Sarah H, Plummer, Cynthia S, Hendel, Laura, Novik, Pamela J M, Costner, Jamie G, Saunders, Matthew B, Laurens, Christopher V, Plowe, Barbara, Flynn, William R, Whalen, J P, Todd, Jay, Noor, Srinivas, Rao, Kailan, Sierra-Davidson, Geoffrey M, Lynn, Judith E, Epstein, Margaret A, Kemp, Gary A, Fahle, Sebastian A, Mikolajczak, Matthew, Fishbaugher, Brandon K, Sack, Stefan H I, Kappe, Silas A, Davidson, Lindsey S, Garver, Niklas K, Björkström, Martha C, Nason, Barney S, Graham, Mario, Roederer, B Kim Lee, Sim, Stephen L, Hoffman, Julie E, Ledgerwood, Robert A, Seder
Publikováno v:
Nature medicine. 22(6)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5ad1dfd70edeebc696235ee5718145d9
https://pubmed.ncbi.nlm.nih.gov/27158907
https://pubmed.ncbi.nlm.nih.gov/27158907
Autor:
Koushi Hidaka, Aiko Kiso, Yoshio Hayashi, Tsuyoshi Uemura, Adam J. Ruben, Mami Kamiya, Yumi Tsuchiya, Tetsuya Okamoto, Tooru Kimura, Ernesto Freire, Yoshiaki Kiso
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:10049-10060
Plasmepsin (Plm) is a potential target for new antimalarial drugs, but most reported Plm inhibitors have relatively low antimalarial activities. We synthesized a series of dipeptide-type HIV protease inhibitors, which contain an allophenylnorstatine-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::500a7f6d00e2482dd4af69d520ec6cbe
https://doi.org/10.1016/j.bmc.2008.10.011
https://doi.org/10.1016/j.bmc.2008.10.011
Autor:
Yumi Tsuchiya, Adam J. Ruben, Tooru Kimura, Ernesto Freire, Mami Kamiya, Yoshiaki Kiso, Yoshio Hayashi, Koushi Hidaka
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:3048-3052
Based on a highly potent allophenylnorstatine-containing inhibitor, KNI-10006, against the plasmepsins of Plasmodium falciparum, we synthesized a series of tripeptide-type compounds with various N-terminal moieties and evaluated their inhibitory acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e72847ccb02b2eaca7010dc8bc7be696
https://doi.org/10.1016/j.bmcl.2007.03.052
https://doi.org/10.1016/j.bmcl.2007.03.052
Autor:
Adam J. Ruben, Laura F. Landweber
Publikováno v:
Nature Reviews Molecular Cell Biology. 1:69-72
Ever since scientists discovered that conventional silicon-based computers have an upper limit in terms of speed, they have been searching for alternative media with which to solve computational problems. That search has led them, among other places,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79e4b5cea33b037417b7b9c599a1a7cf
https://doi.org/10.1038/35036086
https://doi.org/10.1038/35036086
Publikováno v:
Aspartic Acid Proteases as Therapeutic Targets
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a92903941db222a48af057c615a381bf
https://doi.org/10.1002/9783527630943.ch18
https://doi.org/10.1002/9783527630943.ch18
Autor:
Yuko Kawasaki, Adam J. Ruben, Ernesto Freire, Tsuyoshi Uemura, Keisuke Kashimoto, Yuto Hori, Yoshiaki Kiso, Takuya Miura, Tooru Kimura, Koushi Hidaka
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(16)
We attached 2-aminoethylamino groups to allophenylnorstatine-containing plasmepsin (Plm) inhibitors and investigated SAR of the methyl or ethyl substitutions on the amino groups. Unexpectedly, compounds 22 (KNI-10743) and 25 (KNI-10742) exhibited ext
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be82fad5ed0038bbb55473008e6d5a93
https://pubmed.ncbi.nlm.nih.gov/20634066
https://pubmed.ncbi.nlm.nih.gov/20634066
Publikováno v:
Chemical biologydrug design. 67(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bb8a3090507364eda467b610219c277
https://pubmed.ncbi.nlm.nih.gov/16492143
https://pubmed.ncbi.nlm.nih.gov/16492143
Publikováno v:
DNA Computing ISBN: 9783540437758
DNA
DNA
Nearly every nucleotide-based computing problem attempted thus far has involved the prearranged assignment of nucleotide sequences to represent bits. However, no general program is yet available to optimize those bit sequences. Careful selection of b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e61009edefdc4e9a62aad6fea530748c
https://doi.org/10.1007/3-540-48017-x_14
https://doi.org/10.1007/3-540-48017-x_14
Autor:
Tsuyoshi Uemura, Yoshio Hayashi, Tooru Kimura, Ernesto Freire, Koushi Hidaka, Aiko Kiso, Adam J. Ruben, Yumi Tsuchiya, Tetsuya Okamoto, Yoshiaki Kiso, Mami Kamiya
Publikováno v:
Bioorganic & Medicinal Chemistry. 17:1772
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3101be6e687840a689dbdaae2edf1f44
https://doi.org/10.1016/j.bmc.2008.10.094
https://doi.org/10.1016/j.bmc.2008.10.094