Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Adam J, Fletcher"'
Autor:
Adam J. Fletcher, Peter D. Mabbitt
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Externí odkaz:
https://doaj.org/article/5802f57c7a7b40408e8648683205b378
Autor:
Donna L. Mallery, K.M. Rifat Faysal, Alex Kleinpeter, Miranda S.C. Wilson, Marina Vaysburd, Adam J. Fletcher, Mariia Novikova, Till Böcking, Eric O. Freed, Adolfo Saiardi, Leo C. James
Publikováno v:
Cell Reports, Vol 29, Iss 12, Pp 3983-3996.e4 (2019)
Summary: HIV-1 hijacks host proteins to promote infection. Here we show that HIV is also dependent upon the host metabolite inositol hexakisphosphate (IP6) for viral production and primary cell replication. HIV-1 recruits IP6 into virions using two l
Externí odkaz:
https://doaj.org/article/a52365df0e4b4bc7a7ef2dece3f93e77
Autor:
Claire Dickson, Adam J Fletcher, Marina Vaysburd, Ji-Chun Yang, Donna L Mallery, Jingwei Zeng, Christopher M Johnson, Stephen H McLaughlin, Mark Skehel, Sarah Maslen, James Cruickshank, Nicolas Huguenin-Dezot, Jason W Chin, David Neuhaus, Leo C James
Publikováno v:
eLife, Vol 7 (2018)
Cell surface Fc receptors activate inflammation and are tightly controlled to prevent autoimmunity. Antibodies also simulate potent immune signalling from inside the cell via the cytosolic antibody receptor TRIM21, but how this is regulated is unknow
Externí odkaz:
https://doaj.org/article/5202b947b0ec499ebb78db70bf28d54e
Autor:
Peter D. Mabbitt, Michael P. Coleman, Satpal Virdee, Marc-André Déry, Mathew Stanley, Adam J. Fletcher, Andrea Loreto, Nicola T. Wood, Kuan-Chuan Pao
Publikováno v:
Nature Chemical Biology. 16:1227-1236
MYCBP2 is a ubiquitin (Ub) E3 ligase (E3) that is essential for neurodevelopment and regulates axon maintenance. MYCBP2 transfers Ub to nonlysine substrates via a newly discovered RING-Cys-Relay (RCR) mechanism, where Ub is relayed from an upstream c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a34b16eb3e4d1236aa0e426512e9373
https://doi.org/10.1038/s41589-020-0598-6
https://doi.org/10.1038/s41589-020-0598-6
Autor:
Amanda J Price, David A Jacques, William A McEwan, Adam J Fletcher, Sebastian Essig, Jason W Chin, Upul D Halambage, Christopher Aiken, Leo C James
Publikováno v:
PLoS Pathogens, Vol 10, Iss 10, p e1004459 (2014)
The HIV-1 capsid is involved in all infectious steps from reverse transcription to integration site selection, and is the target of multiple host cell and pharmacologic ligands. However, structural studies have been limited to capsid monomers (CA), a
Externí odkaz:
https://doaj.org/article/af6eb117e61e461b8dd82edacf42765a
Autor:
Mathieu Soetens, Satpal Virdee, Nicola T. Wood, Virginia De Cesare, Peter D. Mabbitt, Daniel Carbajo Lopez, Adam J. Fletcher, Odetta Antico
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
The reversibility of ubiquitination by the action of deubiquitinating enzymes (DUBs) serves as an important regulatory layer within the ubiquitin system. Approximately 100 DUBs are encoded by the human genome, and many have been implicated with patho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9214985f9b35dad7e01f1b8694bd9116
https://doi.org/10.1073/pnas.2006947118
https://doi.org/10.1073/pnas.2006947118
Autor:
Amanda J Price, Adam J Fletcher, Torsten Schaller, Tom Elliott, KyeongEun Lee, Vineet N KewalRamani, Jason W Chin, Greg J Towers, Leo C James
Publikováno v:
PLoS Pathogens, Vol 8, Iss 8, p e1002896 (2012)
The HIV-1 genome enters cells inside a shell comprised of capsid (CA) protein. Variation in CA sequence alters HIV-1 infectivity and escape from host restriction factors. However, apart from the Cyclophilin A-binding loop, CA has no known interfaces
Externí odkaz:
https://doaj.org/article/7ebe256ec2ca4132a1a8a19a34467a08
Publikováno v:
Cell Chemical Biology
Summary Activity-based protein profiling is an invaluable technique for studying enzyme biology and facilitating the development of therapeutics. Ubiquitin E3 ligases (E3s) are one of the largest enzyme families and regulate a host of (patho)physiolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcfee5457efb0cb23f3ece8874d77435
https://eprints.gla.ac.uk/245468/1/245468.pdf
https://eprints.gla.ac.uk/245468/1/245468.pdf
Autor:
Torsten Schaller, Karen E Ocwieja, Jane Rasaiyaah, Amanda J Price, Troy L Brady, Shoshannah L Roth, Stéphane Hué, Adam J Fletcher, KyeongEun Lee, Vineet N KewalRamani, Mahdad Noursadeghi, Richard G Jenner, Leo C James, Frederic D Bushman, Greg J Towers
Publikováno v:
PLoS Pathogens, Vol 7, Iss 12, p e1002439 (2011)
Lentiviruses such as HIV-1 traverse nuclear pore complexes (NPC) and infect terminally differentiated non-dividing cells, but how they do this is unclear. The cytoplasmic NPC protein Nup358/RanBP2 was identified as an HIV-1 co-factor in previous stud
Externí odkaz:
https://doaj.org/article/a5b5dc81b6be4ecc85627141155f796e
Autor:
Peter D, Mabbitt, Andrea, Loreto, Marc-André, Déry, Adam J, Fletcher, Mathew, Stanley, Kuan-Chuan, Pao, Nicola T, Wood, Michael P, Coleman, Satpal, Virdee
Publikováno v:
Nature chemical biology. 16(11)
MYCBP2 is a ubiquitin (Ub) E3 ligase (E3) that is essential for neurodevelopment and regulates axon maintenance. MYCBP2 transfers Ub to nonlysine substrates via a newly discovered RING-Cys-Relay (RCR) mechanism, where Ub is relayed from an upstream c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1aaaedfcad6589562f658118747d5855
https://pubmed.ncbi.nlm.nih.gov/33067595
https://pubmed.ncbi.nlm.nih.gov/33067595