Zobrazeno 1 - 10
of 139
pro vyhledávání: '"Adam I. Marcus"'
Autor:
Christina M. Knippler, Jamie L. Arnst, Isaac E. Robinson, Veronika Matsuk, Tala O. Khatib, R. Donald Harvey, Mala Shanmugam, Janna K. Mouw, Haian Fu, Thota Ganesh, Adam I. Marcus
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109591- (2024)
Summary: Targeting cancer metabolism to limit cellular energy and metabolite production is an attractive therapeutic approach. Here, we developed analogs of the bisbiguanide, alexidine, to target lung cancer cell metabolism and assess a structure-act
Externí odkaz:
https://doaj.org/article/23b5922f597f4f7084cf0f89ddff9f8a
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Abstract Spheroid cultures derived from explanted cancer specimens are an increasingly utilized resource for studying complex biological processes like tumor cell invasion and metastasis, representing an important bridge between the simplicity and pr
Externí odkaz:
https://doaj.org/article/8098aaddc24a4afebe20581829e7721b
Autor:
Tala O Khatib, Angelica M Amanso, Christina M Knippler, Brian Pedro, Emily R Summerbell, Najdat M Zohbi, Jessica M Konen, Janna K Mouw, Adam I Marcus
Publikováno v:
PLoS ONE, Vol 18, Iss 10, p e0292554 (2023)
Numerous techniques have been employed to deconstruct the heterogeneity observed in normal and diseased cellular populations, including single cell RNA sequencing, in situ hybridization, and flow cytometry. While these approaches have revolutionized
Externí odkaz:
https://doaj.org/article/fe27ed5d193243e1a74544f879fb7a81
Autor:
Xingming Deng, Jia Zhou, Dong M. Shin, Taofeek K. Owonikoko, Walter J. Curran, Fadlo R. Khuri, Haian Fu, Andrew T. Magis, Suresh S. Ramalingam, Gabriel L. Sica, Zhuo G. Chen, Shi-Yong Sun, Adam I. Marcus, Wei Zhou, Melissa Gilbert-Ross, Guojing Zhang, Guo Chen, Ye Ding, Dongkyoo Park, Maohua Xie, Jun Zhang, Chunyong Ding, Rui Li
A rationale exists for pharmacologic manipulation of the serine (S)184 phosphorylation site of the proapoptotic Bcl2 family member Bax as an anticancer strategy. Here, we report the refinement of the Bax agonist SMBA1 to generate CYD-2-11, which has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d09e6f8b4e77f32ca61f6be4c27d83d
https://doi.org/10.1158/0008-5472.c.6509121.v1
https://doi.org/10.1158/0008-5472.c.6509121.v1
Autor:
Adam I. Marcus, Melissa Gilbert-Ross, Gabriel Sica, Hans E. Grossniklaus, W. David Martin, W.G. Wiles, John Shupe, Jessica M. Konen, Allyson E. Koyen, Lauren S. Havel, Alessandra M. Richardson
Purpose: Vimentin is an epithelial-to-mesenchymal transition (EMT) biomarker and intermediate filament protein that functions during cell migration to maintain structure and motility. Despite the abundance of clinical data linking vimentin to poor pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a544233e5520d2329cb9ea2caad134f5
https://doi.org/10.1158/1078-0432.c.6526205
https://doi.org/10.1158/1078-0432.c.6526205
Autor:
Xingming Deng, Jia Zhou, Dong M. Shin, Taofeek K. Owonikoko, Walter J. Curran, Fadlo R. Khuri, Haian Fu, Andrew T. Magis, Suresh S. Ramalingam, Gabriel L. Sica, Zhuo G. Chen, Shi-Yong Sun, Adam I. Marcus, Wei Zhou, Melissa Gilbert-Ross, Guojing Zhang, Guo Chen, Ye Ding, Dongkyoo Park, Maohua Xie, Jun Zhang, Chunyong Ding, Rui Li
Figure S1. Bak BH3 peptide position in Bak protein. Figure S2. Dephosphorylation of Bax by lambdaPPase in vitro. Figure S3. Bax activators CYD-2-11 and SMBA1 failed to induce Bak oligomerization. Figure S4. Analysis of CYD-2-11 toxicity in vivo. Figu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3a436a52529dc1a5ba872a0d0b3d2e0
https://doi.org/10.1158/0008-5472.22414932
https://doi.org/10.1158/0008-5472.22414932
Autor:
Adam I. Marcus, Paula M. Vertino, Wei Zhou, Fadlo R. Khuri, Katherine Schafer-Hales, Shumin Zhang
Supplementary Figure 1 from The Tumor Suppressor LKB1 Regulates Lung Cancer Cell Polarity by Mediating cdc42 Recruitment and Activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::027b41c2a13ef80def7faab43c201d30
https://doi.org/10.1158/0008-5472.22374827
https://doi.org/10.1158/0008-5472.22374827
Autor:
Adam I. Marcus, Paula M. Vertino, Wei Zhou, Fadlo R. Khuri, Katherine Schafer-Hales, Shumin Zhang
The tumor suppressor LKB1 is mutated in 30% of non–small cell lung cancer (NSCLC) tumors and cell lines and is proposed to be a key regulator of epithelial cell polarity; however, how LKB1 regulates cancer cell polarity is not known. The experiment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b29e7e8eb8933ca3d5d6330e1bb5f089
https://doi.org/10.1158/0008-5472.c.6497594
https://doi.org/10.1158/0008-5472.c.6497594
Autor:
Adam I. Marcus, Paula M. Vertino, Wei Zhou, Fadlo R. Khuri, Katherine Schafer-Hales, Shumin Zhang
Supplementary Figure 2 from The Tumor Suppressor LKB1 Regulates Lung Cancer Cell Polarity by Mediating cdc42 Recruitment and Activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19859698dde06cfd46cbada12e118a0b
https://doi.org/10.1158/0008-5472.22374824
https://doi.org/10.1158/0008-5472.22374824
Autor:
Adam I. Marcus, Paula M. Vertino, Wei Zhou, Fadlo R. Khuri, Katherine Schafer-Hales, Shumin Zhang
Supplementary Figure 3 from The Tumor Suppressor LKB1 Regulates Lung Cancer Cell Polarity by Mediating cdc42 Recruitment and Activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18c34678d366e58bb192ab4459da8713
https://doi.org/10.1158/0008-5472.22374821
https://doi.org/10.1158/0008-5472.22374821