Zobrazeno 1 - 10
of 140
pro vyhledávání: '"Adam I Marcus"'
Autor:
Tala O Khatib, Angelica M Amanso, Christina M Knippler, Brian Pedro, Emily R Summerbell, Najdat M Zohbi, Jessica M Konen, Janna K Mouw, Adam I Marcus
Publikováno v:
PLoS ONE, Vol 18, Iss 10, p e0292554 (2023)
Numerous techniques have been employed to deconstruct the heterogeneity observed in normal and diseased cellular populations, including single cell RNA sequencing, in situ hybridization, and flow cytometry. While these approaches have revolutionized
Externí odkaz:
https://doaj.org/article/fe27ed5d193243e1a74544f879fb7a81
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 5, p e1006131 (2018)
Many tumors are characterized by genetic instability, producing an assortment of genetic variants of tumor cells called subclones. These tumors and their surrounding environments form complex multi-cellular ecosystems, where subclones compete for res
Externí odkaz:
https://doaj.org/article/c58b7352d59a494ea4a5dd733b38b2ba
Autor:
Zhen Yang, Anapatricia Garcia, Songli Xu, Doris R Powell, Paula M Vertino, Shivendra Singh, Adam I Marcus
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75069 (2013)
Though clinicians can predict which patients are at risk for developing metastases, traditional therapies often prove ineffective and metastatic disease is the primary cause of cancer patient death; therefore, there is a need to develop anti-metastat
Externí odkaz:
https://doaj.org/article/a7742008364146ddb1b746a5a5b08b69
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Abstract Spheroid cultures derived from explanted cancer specimens are an increasingly utilized resource for studying complex biological processes like tumor cell invasion and metastasis, representing an important bridge between the simplicity and pr
Externí odkaz:
https://doaj.org/article/8098aaddc24a4afebe20581829e7721b
Autor:
Xingming Deng, Jia Zhou, Dong M. Shin, Taofeek K. Owonikoko, Walter J. Curran, Fadlo R. Khuri, Haian Fu, Andrew T. Magis, Suresh S. Ramalingam, Gabriel L. Sica, Zhuo G. Chen, Shi-Yong Sun, Adam I. Marcus, Wei Zhou, Melissa Gilbert-Ross, Guojing Zhang, Guo Chen, Ye Ding, Dongkyoo Park, Maohua Xie, Jun Zhang, Chunyong Ding, Rui Li
A rationale exists for pharmacologic manipulation of the serine (S)184 phosphorylation site of the proapoptotic Bcl2 family member Bax as an anticancer strategy. Here, we report the refinement of the Bax agonist SMBA1 to generate CYD-2-11, which has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d09e6f8b4e77f32ca61f6be4c27d83d
https://doi.org/10.1158/0008-5472.c.6509121.v1
https://doi.org/10.1158/0008-5472.c.6509121.v1
Autor:
Adam I. Marcus, Melissa Gilbert-Ross, Gabriel Sica, Hans E. Grossniklaus, W. David Martin, W.G. Wiles, John Shupe, Jessica M. Konen, Allyson E. Koyen, Lauren S. Havel, Alessandra M. Richardson
Purpose: Vimentin is an epithelial-to-mesenchymal transition (EMT) biomarker and intermediate filament protein that functions during cell migration to maintain structure and motility. Despite the abundance of clinical data linking vimentin to poor pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a544233e5520d2329cb9ea2caad134f5
https://doi.org/10.1158/1078-0432.c.6526205
https://doi.org/10.1158/1078-0432.c.6526205
Autor:
Xingming Deng, Jia Zhou, Dong M. Shin, Taofeek K. Owonikoko, Walter J. Curran, Fadlo R. Khuri, Haian Fu, Andrew T. Magis, Suresh S. Ramalingam, Gabriel L. Sica, Zhuo G. Chen, Shi-Yong Sun, Adam I. Marcus, Wei Zhou, Melissa Gilbert-Ross, Guojing Zhang, Guo Chen, Ye Ding, Dongkyoo Park, Maohua Xie, Jun Zhang, Chunyong Ding, Rui Li
Figure S1. Bak BH3 peptide position in Bak protein. Figure S2. Dephosphorylation of Bax by lambdaPPase in vitro. Figure S3. Bax activators CYD-2-11 and SMBA1 failed to induce Bak oligomerization. Figure S4. Analysis of CYD-2-11 toxicity in vivo. Figu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3a436a52529dc1a5ba872a0d0b3d2e0
https://doi.org/10.1158/0008-5472.22414932
https://doi.org/10.1158/0008-5472.22414932
Autor:
Adam I. Marcus, Paula M. Vertino, Wei Zhou, Fadlo R. Khuri, Katherine Schafer-Hales, Shumin Zhang
Supplementary Figure 1 from The Tumor Suppressor LKB1 Regulates Lung Cancer Cell Polarity by Mediating cdc42 Recruitment and Activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::027b41c2a13ef80def7faab43c201d30
https://doi.org/10.1158/0008-5472.22374827
https://doi.org/10.1158/0008-5472.22374827
Autor:
Adam I. Marcus, Paula M. Vertino, Wei Zhou, Fadlo R. Khuri, Katherine Schafer-Hales, Shumin Zhang
The tumor suppressor LKB1 is mutated in 30% of non–small cell lung cancer (NSCLC) tumors and cell lines and is proposed to be a key regulator of epithelial cell polarity; however, how LKB1 regulates cancer cell polarity is not known. The experiment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b29e7e8eb8933ca3d5d6330e1bb5f089
https://doi.org/10.1158/0008-5472.c.6497594
https://doi.org/10.1158/0008-5472.c.6497594
Autor:
Adam I. Marcus, Paula M. Vertino, Wei Zhou, Fadlo R. Khuri, Katherine Schafer-Hales, Shumin Zhang
Supplementary Figure 2 from The Tumor Suppressor LKB1 Regulates Lung Cancer Cell Polarity by Mediating cdc42 Recruitment and Activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19859698dde06cfd46cbada12e118a0b
https://doi.org/10.1158/0008-5472.22374824
https://doi.org/10.1158/0008-5472.22374824