Zobrazeno 1 - 7 of 7 pro vyhledávání: '"Adam Huffman"'
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Akademický článek
Advancing data science in drug development through an innovative computational framework for data sharing and statistical analysis
Autor: Ann-Marie Mallon, Dieter A. Häring, Frank Dahlke, Piet Aarden, Soroosh Afyouni, Daniel Delbarre, Khaled El Emam, Habib Ganjgahi, Stephen Gardiner, Chun Hei Kwok, Dominique M. West, Ewan Straiton, Sibylle Haemmerle, Adam Huffman, Tom Hofmann, Luke J. Kelly, Peter Krusche, Marie-Claude Laramee, Karine Lheritier, Greg Ligozio, Aimee Readie, Luis Santos, Thomas E. Nichols, Janice Branson, Chris Holmes
Publikováno v: BMC Medical Research Methodology, Vol 21, Iss 1, Pp 1-11 (2021)
Abstract Background Novartis and the University of Oxford’s Big Data Institute (BDI) have established a research alliance with the aim to improve health care and drug development by making it more efficient and targeted. Using a combination of the
Externí odkaz: https://doaj.org/article/d43dee580b834d6ca85817e178bae918
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2
Advancing data science in drug development through an innovative computational framework for data sharing and statistical analysis
Autor: Thomas E. Nichols, Piet Aarden, E. Straiton, Sibylle Haemmerle, Aimee Readie, Greg Ligozio, Karine Lheritier, M.-C. Laramee, K. El Emam, Janice Branson, Daniel J. Delbarre, Christopher Holmes, Habib Ganjgahi, Soroosh Afyouni, C. H. Kwok, Stephen Gardiner, D. M. West, Peter Krusche, D. A. Haering, T. F. Hofmann, L. F. Kelly, Luis Santos, Ann-Marie Mallon, Frank Dahlke, Adam Huffman
Publikováno v: BMC Medical Research Methodology, Vol 21, Iss 1, Pp 1-11 (2021)
BMC Medical Research Methodology
Background Novartis and the University of Oxford’s Big Data Institute (BDI) have established a research alliance with the aim to improve health care and drug development by making it more efficient and targeted. Using a combination of the latest st
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a657dd557dc6dcb01b728c8f34b36c3c
https://doaj.org/article/d43dee580b834d6ca85817e178bae918
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3
Nautilus: A Precision-Guided Open Data Architecture for Big Omics Data Analysis
Autor: Hai H. Wang, Jon Smith, Steve Hindmarsh, Wei Xing, Mike Gavrielides, Adam Huffman
Publikováno v: 2019 2nd International Conference on Artificial Intelligence and Big Data (ICAIBD).
To make valuable omics data useful is becoming more urgent in medical research. The need to provide information on what and how data can be useful for a particular research question has presented significant challenges in big data management and anal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::828d5d51fcdbccb167ef644b54757c30
https://doi.org/10.1109/icaibd.2019.8836977
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4
Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal
Autor: Emma Nye, Ben Phillimore, Nicholas McGranahan, Gordon Stamp, Archana Fernando, José I. López, Thomas B.K. Watkins, Hang Xu, Lisa Pickering, Kevin Litchfield, David Nicol, Sharmin Begum, Mariam Jamal-Hanjani, Lewis Au, Sharanpreet Lall, Lavinia Spain, Mary Varia, Nicolai Juul Birkbak, Steve Hazell, Eva Grönroos, Nicholas M. Luscombe, Mark Stares, Martin Gore, Alexander Polson, Aspasia Soultati, Ben Challacombe, Marcin Krzystanek, Nicos Fotiadis, Tim Chambers, Aengus Stewart, Ismaeel Aurangzeb, James Larkin, Dezso Ribli, Adam Huffman, Rachel Rosenthal, Orsolya Pipek, Max Salm, Peter J. Campbell, Charles Swanton, Catherine Horsfield, Samra Turajlic, Mickael Escudero, Bruno Silva, Faiz Jabbar, Thomas J. Mitchell, Zoltan Szallasi, Roland F. Schwarz, Simon Chowdhury, Sarkhara Sharma, Ashish Chandra, Sebastijan Hobor, Stuart Horswell, Wei Xing, Gareth A. Wilson, Sophia Ward, Tim O'Brien, Stefan Boeing, Claudia Eichler-Jonsson, Javier Herrero, Andrew Rowan, Nik Matthews, István Csabai, Peter Van Loo, Jonathan C. Smith, Carolina Navas, Greg Elgar, Joanna Lynch, Marta Costa, Sarah Rudman, Rosalie Fisher
Publikováno v: Turajlic, S, Xu, H, Litchfield, K, Rowan, A, Horswell, S, Chambers, T, O'Brien, T, Lopez, J I, Watkins, T B K, Nicol, D, Stares, M, Challacombe, B, Hazell, S, Chandra, A, Mitchell, T J, Au, L, Eichler-Jonsson, C, Jabbar, F, Soultati, A, Chowdhury, S, Rudman, S, Lynch, J, Fernando, A, Stamp, G, Nye, E, Stewart, A, Xing, W, Smith, J C, Escudero, M, Huffman, A, Matthews, N, Elgar, G, Phillimore, B, Costa, M, Begum, S, Ward, S, Salm, M, Boeing, S, Fisher, R, Spain, L, Navas, C, Grönroos, E, Hobor, S, Sharma, S, Aurangzeb, I, Lall, S, Polson, A, Varia, M, Horsfield, C, Fotiadis, N, Pickering, L, Schwarz, R F, Silva, B, Herrero, J, Luscombe, N M, Jamal-Hanjani, M, Rosenthal, R, Birkbak, N J, Wilson, G A, Ribli, D, Pipek, O, Krzystanek, M, Csabai, I, Szallasi, Z I, Gore, M, McGranahan, N, Van Loo, P, Campbell, P, Larkin, J & Swanton, C 2018, ' Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal ', Cell, vol. 173, no. 3, e11, pp. 595-610 . https://doi.org/10.1016/j.cell.2018.03.043
Addi. Archivo Digital para la Docencia y la Investigación
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The evolutionary features of clear-cell renal cell carcinoma (ccRCC) have not been systematically studied to date. We analyzed 1,206 primary tumor regions from 101 patients recruited into the multi-center prospective study, TRACERx Renal. We observe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d622d9e406e6e2589f5c1f9901f920d3
https://orbit.dtu.dk/en/publications/0283a41f-f3c8-4e43-bf37-e06dbf418c61
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5
Actin filaments are required for fibripositor-mediated collagen fibril alignment in tendon
Autor: Sally M. Humphries, Yinhui Lu, David F. Holmes, Eileen T. O'Toole, Elizabeth G. Canty, Karl E. Kadler, Roger S. Meadows, Adam Huffman, Tobias Starborg
Publikováno v: The Journal of biological chemistry. 281(50)
Cells in tendon deposit parallel arrays of collagen fibrils to form a functional tissue, but how this is achieved is unknown. The cellular mechanism is thought to involve the formation of intracellular collagen fibrils within Golgi to plasma membrane
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90f98c27a6ac7ede99e93ad4a3e320a0
https://pubmed.ncbi.nlm.nih.gov/17020878
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