Neutrophils induce paracrine telomere dysfunction and senescence in ROS‐dependent manner

Autor: Leena Habiballa, David Dolan, Anthony B. Lagnado, Madison L. Doolittle, Jodie Birch, Daniel Geh, Helen L. Reeves, Marie-Hélène Ruchaud-Sparagano, Shane A. Evans, Nicola Neretti, Amy L Collins, Sushma Nagaraja Grellscheid, João F. Passos, Derek A. Mann, Thomas von Zglinicki, Sanjay Pandanaboyana, Colin H Wilson, Claudio Akio Masuda, Diana Jurk, Caroline L. Wilson, Tamar Tchkonia, Adam Hruby, Suchira Gallage, Maria Grazia Vizioli, Stella Victorelli, Petra Hirsova, Jack Leslie, Kevin D. Pavelko, Hanna Salmonowicz, Mathias Heikenwalder, Gabriele Saretzki, James Chapman, Sundeep Khosla, Mikolaj Ogrodnik, Bernadette Carroll, James L. Kirkland, Fiona Oakley

Publikováno v: The EMBO Journal
e106048
The EMBO Journal, 2021, Vol.40(9), pp.e106048 [Peer Reviewed Journal]
EMBO Journal
Lagnado, A, Carroll, B, Passos, J F & al., E 2021, ' Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner ', EMBO Journal, vol. 40, no. 9, e106048 . https://doi.org/10.15252/embj.2020106048

Cellular senescence is characterized by an irreversible cell cycle arrest as well as a pro-inflammatory phenotype, thought to contribute to aging and age-related diseases. Neutrophils have essential roles in inflammatory responses; however, in certai

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