Výsledky vyhledávání - "Adam Hassani"

Mitochondrial myopathies: developments in treatment

Autor: Adam Hassani, Patrick F. Chinnery, Rita Horvath

Publikováno v: Current Opinion in Neurology. 23:459-465

Purpose of review Treatment options for mitochondrial myopathies remain limited despite rapid advances in the understanding of the molecular basis of these conditions. Existing therapies continue to be evaluated and novel treatment strategies are sta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dec2d10430f0411f58d8ebfc9a4a54d2
https://doi.org/10.1097/wco.0b013e32833d1096

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An update on clinical outcome data for a phase II randomized study comparing androgen deprivation therapy plus docetaxel versus androgen deprivation therapy alone in men with locally advanced/metastatic hormone sensitive prostate cancer

Autor: J. Frew, Adam Hassani, Rhona McMenemin, Ian Pedley, Ashraf Azzabi

Publikováno v: Journal of Clinical Oncology. 35:259-259

259 Background: Androgen deprivation therapy has been the standard of care for advanced prostate cancer for many years. However recent studies have reported a survival benefit for upfront docetaxel chemotherapy in men with hormone sensitive prostate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4d6b676a6f9cc191ebbc4731a2fe7add
https://doi.org/10.1200/jco.2017.35.6_suppl.259

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Size does matter: High volume breast surgeons accept smaller excision margins for wide local excision--a national survey of the surgical management of wide local excision margins in UK breast cancer patients

Autor: James Harvey, Adam Hassani, Clive Griffith

Publikováno v: Breast (Edinburgh, Scotland). 22(5)

Optimal margins for wide local excision (WLE) have not been clearly established. Larger margins lead to lower recurrence rates but at the expense of cosmetic appearance. NICE guidelines recommend a 2 mm margin for ductal carcinoma in-situ (DCIS), whi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebbf8cc730c7e3bdd8a152f8e2b82c79
https://pubmed.ncbi.nlm.nih.gov/23313329

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Adult-onset spinocerebellar ataxia syndromes due to MTATP6 mutations

Autor: Gerald Pfeffer, Charlotte L. Alston, Patrick F. Chinnery, Robert W. Taylor, David C. Samuels, Rita Horvath, Mike Boggild, Emma L. Blakely, Adam Hassani

Publikováno v: Journal of neurology, neurosurgery, and psychiatry. 83(9)

Background Spinocerebellar ataxia syndromes presenting in adulthood have a broad range of causes, and despite extensive investigation remain undiagnosed in up to ∼50% cases. Mutations in the mitochondrially encoded MTATP6 gene typically cause infan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8deb0a68653d03c69b61b84fcf65744d
https://pubmed.ncbi.nlm.nih.gov/22773856

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Adult-onset cerebellar ataxia due to mutations in CABC1/ADCK3

Autor: Grainne S. Gorman, Patrick F. Chinnery, Robert W. Taylor, Stephanie Demuth, Angela Pyle, Karin Storm, Hanns Lochmüller, Adam Hassani, Gunnar Houge, Christine Dineiger, Charlotte Foley, Elke Holinski-Feder, Birgit Czermin, Michael Brodhun, Sweena Gulati, Janbernd Kirschner, Rita Horvath, Emma L. Blakely

Publikováno v: Journal of neurology, neurosurgery, and psychiatry. 83(2)

Inherited ataxias are heterogeneous disorders affecting both children and adults. The primary cause can be identified in about half of the patients and only very few can receive causative therapy.The authors performed sequencing of known Coenzyme Q10

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d093350de18e7b6c5f72f2427f36407
https://pubmed.ncbi.nlm.nih.gov/22036850

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