Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Adam H. Kramer"'
Autor:
Lisa Baker, Moses Tar, Adam H. Kramer, Guillermo A. Villegas, Rabab A. Charafeddine, Olga Vafaeva, Parimala Nacharaju, Joel Friedman, Kelvin P. Davies, David J. Sharp
Publikováno v:
JCI Insight, Vol 6, Iss 9 (2021)
The microtubule (MT) cytoskeleton plays a critical role in axon growth and guidance. Here, we identify the MT-severing enzyme fidgetin-like 2 (FL2) as a negative regulator of axon regeneration and a therapeutic target for promoting nerve regeneration
Externí odkaz:
https://doaj.org/article/cf05427173e84d079b3f03d51fb497a9
Autor:
Yidong Wang, Bingruo Wu, Pengfei Lu, Donghong Zhang, Brian Wu, Shweta Varshney, Gonzalo del Monte-Nieto, Zhenwu Zhuang, Rabab Charafeddine, Adam H. Kramer, Nicolas E. Sibinga, Nikolaos G. Frangogiannis, Richard N. Kitsis, Ralf H. Adams, Kari Alitalo, David J. Sharp, Richard P. Harvey, Pamela Stanley, Bin Zhou
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Though coronary arteries are crucial for heart function, the mechanisms guiding their formation are largely unknown. Here, Wang et al. identify a unique, endocardially-derived angiogenic precursor cell population for coronary artery formation in mice
Externí odkaz:
https://doaj.org/article/ea93cbead9a042ce807dbd39e7d1c160
Publikováno v:
Biophysical Journal.
The microtubule (MT) cytoskeleton and its dynamics play an important role in cell migration. Depletion of the microtubule-severing enzyme Fidgetin-like 2 (FL2), a regulator of MT dynamics at the leading edge of migrating cells, leads to faster and mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::796d0af22c8a0ae6387b712f0234130a
https://doi.org/10.1016/j.bpj.2022.12.018
https://doi.org/10.1016/j.bpj.2022.12.018
Autor:
L. Baker, Parimala Nacharaju, Joel M. Friedman, Adam H. Kramer, Kelvin P. Davies, Moses Tar, David J. Sharp, Guillermo Villegas, Rabab A. Charafeddine, Olga Vafaeva
Publikováno v:
JCI Insight, Vol 6, Iss 9 (2021)
JCI Insight
JCI Insight
The microtubule (MT) cytoskeleton plays a critical role in axon growth and guidance. Here, we identify the MT-severing enzyme fidgetin-like 2 (FL2) as a negative regulator of axon regeneration and a therapeutic target for promoting nerve regeneration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7d50a172135676e73adbecc0791a0c0
https://doi.org/10.1172/jci.insight.138484
https://doi.org/10.1172/jci.insight.138484
Autor:
Kelvin P. Davies, Rabab A. Charafeddine, Moses Tar, L. Baker, Guillermo Villegas, Adam H. Kramer, Parimala Nacharaju, Joel M. Friedman, Olga Vafaeva, David J. Sharp
The microtubule (MT) cytoskeleton plays a critical role in axon growth and guidance. Here, we identify the MT severing enzyme fidgetin-like 2 (FL2) as a negative regulator of axonal regeneration and a potential therapeutic target for promoting neural
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2eea1deb074785e28ebd3d0c222dd5f
https://doi.org/10.1101/2020.03.19.999508
https://doi.org/10.1101/2020.03.19.999508
Autor:
Juan Liu, L. Baker, Parimala Nacharaju, Yuan Miao, David J. Sharp, Joel M. Friedman, Jessie Wang, Abhinav Dey, Cheng Zhang, Roy S. Chuck, Adam H. Kramer
Publikováno v:
Translational Vision Science & Technology
PurposeTo determine the efficacy of nanoparticle-encapsulated FL2 siRNA (FL2-NPsi), a novel therapeutic agent targeting the Fidgetin-like 2 (FL2) gene, for the treatment of corneal alkaline chemical injury.MethodsEighty 12-week-old, male Sprague-Dawl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbdf6950971420f2c99a4eb4e3526fba
https://doi.org/10.1167/tvst.10.1.17
https://doi.org/10.1167/tvst.10.1.17
Autor:
Brian P. O’Rourke, Longyue L Cao, Jayakumar Rajadas, Mohammed Inayathullah, Joshua D. Nosanchuk, David J. Sharp, Adam H. Kramer, Hillary Guzik
Publikováno v:
Advances in Wound Care
Microtubules (MTs) are intracellular polymers that provide structure to the cell, serve as railways for intracellular transport, and regulate many cellular activities, including cell migration. The dynamicity and function of the MT cytoskeleton are d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3e2218d4a43e2ac19e486cd79ca039e
https://pubmed.ncbi.nlm.nih.gov/30911440
https://pubmed.ncbi.nlm.nih.gov/30911440
Publikováno v:
Journal of Cellular Biochemistry. 116:1232-1240
A mechanistic relationship exists between protein localisation, activity and cellular differentiation. Understanding the contribution of these molecular mechanisms is required for elucidation of conditions that drive development. Literature suggests
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88fea4e06c741f766974a91aff8664c6
https://doi.org/10.1002/jcb.25076
https://doi.org/10.1002/jcb.25076
Autor:
Ralf H. Adams, Bin Zhou, Adam H. Kramer, Nicolas E. Sibinga, Pengfei Lu, Bingruo Wu, Zhenwu Zhuang, Yidong Wang, Kari Alitalo, Nikolaos G. Frangogiannis, Rabab A. Charafeddine, Richard P. Harvey, Brian Wu, Richard N. Kitsis, Gonzalo del Monte-Nieto, Pamela Stanley, Donghong Zhang, Shweta Varshney, David J. Sharp
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Coronary artery anomalies may cause life-threatening cardiac complications; however, developmental mechanisms underpinning coronary artery formation remain ill-defined. Here we identify an angiogenic cell population for coronary artery formation in m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8917e5712d943b8acd8fccdaba7925e
https://pubmed.ncbi.nlm.nih.gov/28924218
https://pubmed.ncbi.nlm.nih.gov/28924218
Autor:
Julia Joos-Vandewalle, Michelle Parsons, Heinrich C. Hoppe, Adam H. Kramer, Earl Prinsloo, Zikhona Njengele, Rose Kadye
Publikováno v:
IUBMB Life. 66:42-45
Mitochondria are key to eukaryotic cell survival and their activity is linked to generation of reactive oxygen species (ROS) which in turn acts as both an intracellular signal and an effective executioner of cells with regards to cellular senescence.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4eb52f3c7c5780acf779c5a63a183d9
https://doi.org/10.1002/iub.1234
https://doi.org/10.1002/iub.1234