Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Adam H Hart"'
Autor:
Georgina Caruana, Peter G Farlie, Adam H Hart, Stefan Bagheri-Fam, Megan J Wallace, Michael S Dobbie, Christopher T Gordon, Kerry A Miller, Belinda Whittle, Helen E Abud, Ruth M Arkell, Timothy J Cole, Vincent R Harley, Ian M Smyth, John F Bertram
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e55429 (2013)
Mice harbouring gene mutations that cause phenotypic abnormalities during organogenesis are invaluable tools for linking gene function to normal development and human disorders. To generate mouse models harbouring novel alleles that are involved in o
Externí odkaz:
https://doaj.org/article/4ef49950460e4f1d88f053a4f9e96464
Autor:
Almas R. Juma, Sylvia V. H. Grommen, Moira K. O’Bryan, Anne E. O’Connor, D. Jo Merriner, Nathan E. Hall, Stephen R. Doyle, Pauliina E. Damdimopoulou, Daniel Barriga, Adam H. Hart, Wim J. M. Van de Ven, Bert De Groef
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Deficiency in pleomorphic adenoma gene 1 (PLAG1) leads to reduced fertility in male mice, but the mechanism by which PLAG1 contributes to reproduction is unknown. To investigate the involvement of PLAG1 in testicular function, we determined
Externí odkaz:
https://doaj.org/article/f9a9c5dca672498dbf31f37666823195
Autor:
John E. La Marca, Helena E. Richardson, Adam H. Hart, W. Gregory Somers, Sarah T. Diepstraten, Amy L. Hodge, Hongyan Wang
Publikováno v:
Development.
One fundamental property of a stem cell niche is the exchange of molecular signals between its component cells. Niche models, such as the Drosophila melanogaster testis, have been instrumental in identifying and studying the conserved genetic factors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::793b7b3cff945aee5e8cea58f17db3e3
https://doi.org/10.1242/dev.174292
https://doi.org/10.1242/dev.174292
Autor:
Adam H. Hart, Sarah T. Diepstraten
Publikováno v:
Blood reviews. 33
Genetic lesions of the β-globin gene result in haemoglobinopathies such as β-thalassemia and sickle cell disease. To discover and test new molecular medicines for β-haemoglobinopathies, cell-based and animal models are now being widely utilised. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a11395767282c5bd0f0d58863fabe3a1
https://pubmed.ncbi.nlm.nih.gov/30616747
https://pubmed.ncbi.nlm.nih.gov/30616747
Autor:
Anne E O'Connor, Daniel Barriga, Bert De Groef, Nathan E. Hall, Stephen R. Doyle, Moira K O'Bryan, Pauliina Damdimopoulou, Sylvia V.H. Grommen, Almas R. Juma, Adam H. Hart, Wim J.M. Van de Ven, D. Jo Merriner
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Deficiency in pleomorphic adenoma gene 1 (PLAG1) leads to reduced fertility in male mice, but the mechanism by which PLAG1 contributes to reproduction is unknown. To investigate the involvement of PLAG1 in testicular function, we determined (i) the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cc3b9d021fde2a7a61b95b3b7b909b0
http://europepmc.org/articles/PMC5509656
http://europepmc.org/articles/PMC5509656
Publikováno v:
Communications in Computer and Information Science ISBN: 9789811028564
This research studies the geographic diversity and variation in informal communities within a globally distributed bank in Australia and how these differences impact on the effectiveness of internal collaboration within a Bank. Its social networking
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2179fd9fc035a8dc0c64b76ca6cad1b7
https://doi.org/10.1007/978-981-10-2857-1_3
https://doi.org/10.1007/978-981-10-2857-1_3
Autor:
Bhupinder Pal, Juliet D. French, Frank Feleppa, Stephen B. Fox, Geoffrey J. Lindeman, Elgene Lim, Adam H. Hart, Di Wu, Heather Thorne, David E. Gyorki, Melissa A. Brown, Gordon K. Smyth, François Vaillant, Audrey Partanen, Jane E. Visvader, Teresa Ward, Lily I. Huschtscha, Marie Liesse Asselin-Labat, Max Yan, Natasha C. Forrest
Publikováno v:
Nature Medicine. 15:907-913
Basal-like breast cancers arising in women carrying mutations in the BRCA1 gene, encoding the tumor suppressor protein BRCA1, are thought to develop from the mammary stem cell. To explore early cellular changes that occur in BRCA1 mutation carriers,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0e815c6450445e23dbcd0777c0f987e
https://doi.org/10.1038/nm.2000
https://doi.org/10.1038/nm.2000
Autor:
Eugenio Marco, Robert L. Karp, Lorenzo Trippa, Adam H. Hart, Guo-Cheng Yuan, Guoji Guo, Paul Robson
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 111(52)
We present single-cell clustering using bifurcation analysis (SCUBA), a novel computational method for extracting lineage relationships from single-cell gene expression data and modeling the dynamic changes associated with cell differentiation. SCUBA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65aed782f16d221c3f0ac4a55265b1ce
https://pubmed.ncbi.nlm.nih.gov/25512504
https://pubmed.ncbi.nlm.nih.gov/25512504
Autor:
Lorraine Robb, Marilyn Ibrahim, Leendert H.J. Looijenga, Chung Wo Chow, Adam H. Hart, Lynne Hartley, Karen M. Parker, Marija Pauchnik
Publikováno v:
Cancer. 104:2092-2098
BACKGROUND The NANOG gene, a member of the homeobox family of DNA binding transcription factors, was recently identified in a screen for pluripotency-promoting genes. NANOG overexpression in murine embryonic stem cells is sufficient to maintain self-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe656ef811f0714907024c28741729c3
https://doi.org/10.1002/cncr.21435
https://doi.org/10.1002/cncr.21435
Publikováno v:
Biochemical and Biophysical Research Communications. 333:1361-1369
Mixl1 is a paired-type homeodomain protein that plays a crucial role in morphogenesis and endoderm differentiation in the murine embryo. To understand how Mixl1 directs embryogenesis, we studied the regulation of Mixl1 expression at a transcriptional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f44d61d4341a13c6fadadd560287edfb
https://doi.org/10.1016/j.bbrc.2005.06.044
https://doi.org/10.1016/j.bbrc.2005.06.044