Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Adam H Courtney"'
Autor:
Boryana N Manz, Ying Xim Tan, Adam H Courtney, Florentine Rutaganira, Ed Palmer, Kevan M Shokat, Arthur Weiss
Publikováno v:
eLife, Vol 4 (2015)
The C-terminal Src kinase (Csk), the primary negative regulator of Src-family kinases (SFK), plays a crucial role in controlling basal and inducible receptor signaling. To investigate how Csk activity regulates T cell antigen receptor (TCR) signaling
Externí odkaz:
https://doaj.org/article/e6653f63875c4a5a97e6f38492b929c7
Publikováno v:
Journal of immunological methods. 506
Immunotherapies have transformed the treatment of cancer through the development of drugs that allow T cells to recognize and kill malignant cells. With this has come a need to evaluate how these drugs affect T cell function. We developed an imaging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b03813f697a055a7c19345845a07071
https://pubmed.ncbi.nlm.nih.gov/35644255
https://pubmed.ncbi.nlm.nih.gov/35644255
Publikováno v:
The Journal of Immunology. 208:55.14-55.14
The anti-tumor response of cytotoxic T cells requires detection of tumor-derived antigenic peptide-MHC complex (pMHC) by the T cell antigen receptor (TCR). Strategies that boost TCR signaling caused by weak pMHC could augment the recognition of poorl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bb3086c97409a1e2a5d33b228e11d3e
https://doi.org/10.4049/jimmunol.208.supp.55.14
https://doi.org/10.4049/jimmunol.208.supp.55.14
Autor:
Arthur Weiss, Gloria Griffante, Ondrej Stepanek, Marianne Mollenauer, Wen Lu, Adam H. Courtney, Wan-Lin Lo, Alexey A. Shvets, Arup K. Chakraborty, Veronika Horkova, Steven Yu
Publikováno v:
PMC
Copyright © 2019 The Authors T cells require the protein tyrosine phosphatase CD45 to detect and respond to antigen because it activates the Src family kinase Lck, which phosphorylates the T cell antigen receptor (TCR) complex. CD45 activates Lck by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a2ad141e8e49f5c99047e97ca72331a
https://doi.org/10.1126/scisignal.aaw8151
https://doi.org/10.1126/scisignal.aaw8151
The mechanisms by which a T cell detects antigen using its T cell antigen receptor (TCR) are crucial to our understanding of immunity and the harnessing of T cells therapeutically. A hallmark of the T cell response is the ability of T cells to quanti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b455c9ed63d5c4d88b34e8b9feab21d1
https://europepmc.org/articles/PMC5801066/
https://europepmc.org/articles/PMC5801066/
Publikováno v:
ACS Chemical Biology. 9:202-210
B cells detect foreign antigens through their B cell antigen receptor (BCR). The BCR, when engaged by antigen, initiates a signaling cascade. Concurrent with signaling is endocytosis of the BCR complex, which acts to downregulate signaling and facili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a456dfdd9395d8afdd67dab023d5c6ab
https://doi.org/10.1021/cb400532y
https://doi.org/10.1021/cb400532y
Autor:
Margaret L. Wong, Anthony J. Fowler, Adam H. Courtney, Rachael T. C. Sheridan, Laura L. Kiessling, Joseph R. Klim, Paul J. Wrighton
Publikováno v:
ACS Chemical Biology. 7:518-525
Integrins play myriad and vital roles in development and disease. They connect a cell with its surroundings and transmit chemical and mechanical signals across the plasma membrane to the cell’s interior. Dissecting their roles in cell behavior is c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faf973e600bf2f0a7be72fc6fa13a19b
https://doi.org/10.1021/cb2004725
https://doi.org/10.1021/cb2004725
Publikováno v:
Proceedings of the National Academy of Sciences. 106:2500-2505
CD22 is an inhibitory coreceptor on the surface of B cells that attenuates B cell antigen receptor (BCR) signaling and, therefore, B cell activation. Elucidating the molecular mechanisms underlying the inhibitory activity of CD22 is complicated by th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77e4b033dd743ad970f0a566efc4ecce
https://doi.org/10.1073/pnas.0807207106
https://doi.org/10.1073/pnas.0807207106
Autor:
Boryana N. Manz, Ed Palmer, Kevan M. Shokat, Arthur Weiss, Adam H. Courtney, Ying Xim Tan, Florentine U. Rutaganira
Publikováno v:
eLife, vol 4, iss AUGUST2015
Manz, BN; Tan, YX; Courtney, AH; Rutaganira, F; Palmer, E; Shokat, KM; et al.(2015). Small molecule inhibition of Csk alters affinity recognition by T cells. eLife, 4(AUGUST2015). doi: 10.7554/eLife.08088. UCSF: Retrieved from: http://www.escholarship.org/uc/item/95p5m15s
eLife
eLife, Vol 4 (2015)
Manz, BN; Tan, YX; Courtney, AH; Rutaganira, F; Palmer, E; Shokat, KM; et al.(2015). Small molecule inhibition of Csk alters affinity recognition by T cells. eLife, 4(AUGUST2015). doi: 10.7554/eLife.08088. UCSF: Retrieved from: http://www.escholarship.org/uc/item/95p5m15s
eLife
eLife, Vol 4 (2015)
The C-terminal Src kinase (Csk), the primary negative regulator of Src-family kinases (SFK), plays a crucial role in controlling basal and inducible receptor signaling. To investigate how Csk activity regulates T cell antigen receptor (TCR) signaling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5849a45ee081fe8e947fa12d4548ccd4
https://escholarship.org/uc/item/95p5m15s
https://escholarship.org/uc/item/95p5m15s