Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Adam Gorlewicz"'
Autor:
Silvia Viana da Silva, Matthias Georg Haberl, Pei Zhang, Philipp Bethge, Cristina Lemos, Nélio Gonçalves, Adam Gorlewicz, Meryl Malezieux, Francisco Q. Gonçalves, Noëlle Grosjean, Christophe Blanchet, Andreas Frick, U Valentin Nägerl, Rodrigo A. Cunha, Christophe Mulle
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Hippocampal synaptic dysfunctions are an early symptom of Alzheimer’s disease. Here, the authors find adenosine A2A receptors are up-regulated in APP/PS1 model mice and that deleting or blocking receptor activity helps alleviate plasticity and memo
Externí odkaz:
https://doaj.org/article/1ea75979789f4071b6f94deca86c19df
Autor:
Adam Gorlewicz, Leszek Kaczmarek
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 6 (2018)
Chemical synapses are specialized interfaces between neurons in the brain that transmit and modulate information, thereby integrating cells into multiplicity of interacting neural circuits. Cell adhesion molecules (CAMs) might form trans-synaptic com
Externí odkaz:
https://doaj.org/article/9b5b0f4afc6b4829a477e5fd03984ed3
Autor:
Angélique Peret, Louisa A. Christie, David W. Ouedraogo, Adam Gorlewicz, Jérôme Epsztein, Christophe Mulle, Valérie Crépel
Publikováno v:
Cell Reports, Vol 8, Iss 2, Pp 347-354 (2014)
Kainate is a potent neurotoxin known to induce acute seizures. However, whether kainate receptors (KARs) play any role in the pathophysiology of temporal lobe epilepsy (TLE) is not known. In TLE, recurrent mossy fiber (rMF) axons form abnormal excita
Externí odkaz:
https://doaj.org/article/60b900b7874f406fadfd7af7506616d6
Autor:
Adam Gorlewicz, Jakub Wlodarczyk, Ewa Wilczek, Maciej Gawlak, Anna Cabaj, Henryk Majczynski, Klaudia Nestorowicz, Magdalena Aneta Herbik, Pawel Grieb, Urszula Slawinska, Leszek Kaczmarek, Grzegorz M. Wilczynski
Publikováno v:
Neurobiology of Disease, Vol 34, Iss 2, Pp 245-258 (2009)
CD44 is a multifunctional cell surface glycoprotein which regulates cell–cell and cell–matrix interactions in a variety of tissues. In particular, the protein was found to be expressed in glial cells of developing, but not adult, peripheral nerve
Externí odkaz:
https://doaj.org/article/f06a90a6043d4fab8f78ded1bc96856a
Autor:
Gaël Barthet, Ana Moreira-de-Sá, Pei Zhang, Séverine Deforges, Jorge Castanheira, Adam Gorlewicz, Christophe Mulle
Publikováno v:
J Neurosci
Kainate receptors (KARs) form a family of ionotropic glutamate receptors that regulate the activity of neuronal networks by both presynaptic and postsynaptic mechanisms. Their implication in pathologies is well documented for epilepsy. The higher pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e6f5a42eef51203c66892c96d3c5d03
https://doi.org/10.1523/jneurosci.0297-22.2022
https://doi.org/10.1523/jneurosci.0297-22.2022
Autor:
Adam Gorlewicz, Christophe Mulle, Grzegorz M. Wilczynski, Stefano Zucca, Peggy Vincent, Marilena Griguoli, Noelle Grosjean, Gaël Barthet
Publikováno v:
Cerebral Cortex
Cerebral Cortex, Oxford University Press (OUP), 2021, ⟨10.1093/cercor/bhab390⟩
Cerebral Cortex, Oxford University Press (OUP), 2021, ⟨10.1093/cercor/bhab390⟩
Kainate receptors (KARs) are key regulators of synaptic circuits by acting at pre- and postsynaptic sites through either ionotropic or metabotropic actions. KARs can be activated by kainate, a potent neurotoxin, which induces acute convulsions. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cae698449e15d93f5150a3af9c46cb78
https://doi.org/10.1093/cercor/bhab390
https://doi.org/10.1093/cercor/bhab390
Autor:
Grzegorz M. Wilczynski, Katarzyna Krawczyk, Christophe Mulle, Pawel Trzaskoma, Andrzej A. Szczepankiewicz, Adam Gorlewicz
Publikováno v:
Neuroinformatics. 18:661-664
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f60ed7f51326b28e07e1de05db29198
https://doi.org/10.1007/s12021-020-09465-9
https://doi.org/10.1007/s12021-020-09465-9
Publikováno v:
Experimental neurology. 354
NMDAR is an ionotropic glutamate receptor critically involved in excitatory synaptic transmission. The receptor properties are strongly determined by its subunit composition. One of the NMDAR subunits is GluN2B, which displays restricted and spatiall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5086c122b99ae54ed8c028b9cc0b26e
https://pubmed.ncbi.nlm.nih.gov/35469852
https://pubmed.ncbi.nlm.nih.gov/35469852
Publikováno v:
The Journal of Physiology. 596:703-716
Key points CA3 pyramidal cells display input-specific differences in the subunit composition of synaptic NMDA receptors (NMDARs). Although at low density, GluN2B contributes significantly to NMDAR-mediated EPSCs at mossy fibre synapses. Long-term pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3513d64bce7271119a599636869f5001
https://doi.org/10.1113/jp275226
https://doi.org/10.1113/jp275226
Autor:
Emilia Rejmak, Jakub Wlodarczyk, Jerzy W. Mozrzymas, Tomasz Wójtowicz, Matylda Roszkowska, Blazej Ruszczycki, Grzegorz M. Wilczynski, Anna Konopka, M. Kisiel, Ewelina Knapska, H. Dolezyczek, Joanna Dzwonek, Marek Bekisz, Anna Skupien, Adam Gorlewicz
Publikováno v:
Molecular Biology of the Cell
CD44 is a novel molecular player that regulates structure and function of the synapse. It affects excitatory synaptic transmission, dendritic spine shape, number of functional synapses, and activity-dependent neuronal plasticity. These functions are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eea2019e72c9861bb06052cce79f0b6
https://doi.org/10.1091/mbc.e16-06-0423
https://doi.org/10.1091/mbc.e16-06-0423