Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Adam G. Newman"'
Autor:
Gaurav Shakya, Jordan L. Meier, Craig A. Townsend, Timothy R. Valentic, Jesus F. Barajas, Nathan Gamarra, Kara Finzel, Delsy Martinez, Anna L. Vagstad, Adam G. Newman, Shiou-Chuan Tsai, Michael D. Burkart
Publikováno v:
Angewandte Chemie (International ed. in English), vol 55, iss 42
In fungal non-reducing polyketide synthases (NR-PKS), the acyl-carrier protein (ACP) carries the growing polyketide intermediate through iterative rounds of elongation, cyclization and product release. This process occurs through a controlled, yet en
Publikováno v:
Journal of the American Chemical Society
Iterative, nonreducing polyketide synthases (NR-PKSs) are multidomain enzymes responsible for the construction of the core architecture of aromatic polyketide natural products in fungi. Engineering these enzymes for the production of non-native metab
Autor:
Adam G. Newman, Craig A. Townsend
Publikováno v:
Journal of the American Chemical Society. 138(12)
Perylenequinones are a class of photoactivated polyketide mycotoxins produced by fungal plant pathogens that notably produce reactive oxygen species with visible light. The best-studied perylenequinone is cercosporin—a product of the Cercospora spe
Autor:
Katherine Belecki, Adam G. Newman, Anna L. Vagstad, Philip A. Storm, Craig A. Townsend, Jason M. Crawford
Publikováno v:
Angewandte Chemie (International ed. in English). 52(6)
Polyketide natural products encompass a structurally and functionally diverse family of molecules ranging from those of pharmaceutical importance to environmental toxins adversely affecting plant and animal health. Apart from the giant, modular polyk
Autor:
Adam G. Newman, Jason W. Labonte, Jason M. Crawford, Shiou-Chuan Tsai, Craig A. Townsend, Tyler P. Korman, Justin Wong
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 107(14)
Polyketide natural products possess diverse architectures and biological functions and share a subset of biosynthetic steps with fatty acid synthesis. The final transformation catalyzed by both polyketide synthases (PKSs) and fatty acid synthases is
Autor:
Adam G. Newman, Julie T. Millard, Frederick J. LaRiviere, Megan L. Watts, Justin E. Juskewitch, Paul G. Greenwood, Sharonda Q. Bradley
Publikováno v:
Mutation research. 664(1-2)
The bifunctional alkylating agents diepoxybutane (DEB) and epichlorohydrin (ECH) are linked to the elevated incidence of certain cancers among workers in the synthetic polymer industry. Both compounds form interstrand cross-links within duplex DNA, a
Publikováno v:
Chemical Communications. 48:11772
The polyketide synthase CTB1 is demonstrated to catalyze pyrone formation thereby expanding the known biosynthetic repertoire of thioesterase domains in iterative, non-reducing polyketide synthases.
Publikováno v:
Chemical Research in Toxicology; May2007, Vol. 20 Issue 5, p832-838, 7p