Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Adam G. Bond"'
Autor:
Eugenio Gaudio, Fabrizio Manetti, Sinforosa Gagliardi, Elena Petricci, Silvia Pietrobono, Laura Carrassa, Mariapaola Zitani, Nikolai Makukhin, Adam G. Bond, Barbara Stecca, Martin E. Fernandez-Zapico, Francesca Migliorini, Francesco Bertoni, Alessio Ciulli, Brooke D. Paradise
Publikováno v:
Oncogene
Despite the development of new targeted and immune therapies, the prognosis of metastatic melanoma remains bleak. Therefore, it is critical to better understand the mechanisms controlling advanced melanoma to develop more effective treatment regimens
Publikováno v:
Journal of Medicinal Chemistry
Bifunctional PROTAC degraders belong to "beyond Rule of 5" chemical space, and criteria for predicting their drug-like properties are underdeveloped. PROTAC components are often combined via late-stage amide couplings, due to the reliability and robu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::226920245ada52fb4ef09296381b6379
https://doi.org/10.26434/chemrxiv-2021-47tqn
https://doi.org/10.26434/chemrxiv-2021-47tqn
Publikováno v:
Targeted Protein Degradation ISBN: 9781071616642
The rapid and ever-growing advancements from within the field of proteolysis-targeting chimeras (PROTAC)-induced protein degradation have driven considerable development to gain a deeper understanding of their mode of action. The ternary complex form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a9b69b06493ea60a48834dea616c929
https://doi.org/10.1007/978-1-0716-1665-9_5
https://doi.org/10.1007/978-1-0716-1665-9_5
Publikováno v:
Organicbiomolecular chemistry. 18(38)
Developing stereoselective synthetic routes that are efficient and cost-effective is important to allow easy access to biologically active molecules. Our previous syntheses of allele-selective bumped inhibitors of the Bromo and Extra-Terminal (BET) b