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pro vyhledávání: '"Adam Flinders"'
Autor:
Han Dai, Robert P. Law, John P. Evans, Gillian F. Watt, Chun-wa Chung, Markus A. Queisser, John D. Harling, Antonia J. Lewis, Marcus Bantscheff, João Osvaldo Rodrigues Nunes, Adam Flinders, Paul Scott-Stevens, Andrew B. Benowitz, Peter Stacey, Christopher J. Tame, Karol Buda, Diana Klimaszewska, Marcel Muelbaier, Nico Zinn
Publikováno v:
Angewandte Chemie. 133:23515-23522
Focal adhesion kinase (FAK) is a key mediator of tumour progression and metastasis. To date, clinical trials of FAK inhibitors have reported disappointing efficacy for oncology indications. We report the design and characterisation of GSK215, a poten