Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Adam Flegg"'
Autor:
Adam Flegg, Tina Morwick, Ho Yin Lo, Todd Bosanac, Weimin Liu, Valentina Berger, Steven Kerr, Stéphane De Lombaert, Paige Erin Mahaney, Ralph Binetti, John Broadwater, Spencer Napier, Alessandra Bartolozzi, Lifen Wu, Hidenori Takahashi, Asitha Abeywardane, Heather Tye, Tazmeen Fadra-Khan, John D. Huber, Adrian Kotey, Ming-Hong Hao, Dines Jonathon Alan, Anil Kumar Padyana, Alan Olague, Michael Garrigou, David S. Thomson, J. Matthew Hutzler, Pui Leng Loke, Renee Zindell, Edward Pack, Zhidong Chen, Rebecca Crux, Thomas Simpson, Rajvee Dave, Doris Riether
Publikováno v:
Journal of Medicinal Chemistry. 58:1669-1690
The synthesis, structure–activity relationship (SAR), and evolution of a novel series of oxadiazole-containing 5-lipoxygenase-activating protein (FLAP) inhibitors are described. The use of structure-guided drug design techniques provided compounds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ec30afc1732226a8a2acaaba6be03b4
https://doi.org/10.1021/jm501185j
https://doi.org/10.1021/jm501185j
Autor:
Adrian Kotei Kotey, Stephen P. East, Kai Gerlach, Mildred Williams, Samantha Jayne Bamford, Adam Flegg, Pui Loke, Mark Whittaker, Ralf Heilker, Gerhard Schänzle, Christian Eickmeier, Mark J. Gemkow, Schubert Hans-Dieter, Matthias G. A. Dietz, Bastian Hengerer, Boris Ferger, John D. Scott, Przemyslaw Zawadzki
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(16)
A high-throughput screening campaign identified 4-((E)-styryl)-pyrimidin-2-ylamine (11) as a positive allosteric modulator of the metabotropic glutamate (mGlu) receptor subtype 4. An evaluation of the structure-activity relationships (SAR) of 11 is d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::293947fe0faf4e3e6182fa595d452032
https://pubmed.ncbi.nlm.nih.gov/20638279
https://pubmed.ncbi.nlm.nih.gov/20638279
Autor:
J. Thomas Peterson, Adam Flegg, Christopher Ronald Sarko, Raj Nagaraja, Neil Moss, Heather Tye, Spencer Napier, Ashley Parker, Andreas F. Kahrs, Mark Whitaker, Younggi Choi, Derek Cogan, Orietta Meyn, Philip D. Ramsden, Josh Tomlinson, Donna Skow, Pui Loke
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(8)
We have been exploring the potential of 5-HT2B antagonists as a therapy for chronic heart failure. To assess the potential of this therapeutic approach, we sought compounds possessing the following attributes: (a) potent and selective antagonism of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7f8559f5fcb39bd2b7f8c2f15180d9c
https://pubmed.ncbi.nlm.nih.gov/19307114
https://pubmed.ncbi.nlm.nih.gov/19307114
Autor:
Kenneth Keavey, Russell J. Thomas, Thomas McDonagh, Hamelin Estelle, Rory A. J. Curtis, Jonathan Barker, Peter S. DiStefano, Patricia Amouzegh, Jean-François Pons, Wei Tsung Yau, Andrew Napper, Jeffrey Hixon, M. J. Kates, Stephen Jones, Jeffrey O. Saunders, Manuel A. Navia, Adam Flegg
Publikováno v:
Journal of Medicinal Chemistry. 50:1086-1086
High-throughput screening against the human sirtuin SIRT1 led to the discovery of a series of indoles as potent inhibitors that are selective for SIRT1 over other deacetylases and NAD-processing enzymes. The most potent compounds described herein inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::688909b83bf7f2eb12f50310167448a1
https://doi.org/10.1021/jm061430o
https://doi.org/10.1021/jm061430o
Autor:
Andrew D. Napper, Jeffrey Hixon, Thomas McDonagh, Kenneth Keavey, Jean-Francois Pons, Jonathan Barker, Wei Tsung Yau, Patricia Amouzegh, Adam Flegg, Estelle Hamelin, Russell J. Thomas, Michael Kates, Stephen Jones, Manuel A. Navia, Jeffrey O. Saunders, Peter S. DiStefano, Rory Curtis:
Publikováno v:
Journal of Medicinal Chemistry; Mar2007, Vol. 50 Issue 5, p1086-1086, 1p