Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Adam Filipczyk"'
Autor:
Kang-Xuan Jin, Adam Filipczyk, Rujuan Zuo, Konstantinos Anastassiadis, Arne Klungland, Carsten Marr
Publikováno v:
Proc. Natl. Acad. Sci. U.S.A. 118:e2105192118 (2021)
N6-methyladenosine (m6A) deposition on messenger RNA (mRNA) controls embryonic stem cell (ESC) fate by regulating the mRNA stabilities of pluripotency and lineage transcription factors (TFs) [P. J. Batista etal., Cell Stem Cell 15, 707-719 (2014); Y.
Autor:
Kang-Xuan, Jin, Rujuan, Zuo, Konstantinos, Anastassiadis, Arne, Klungland, Carsten, Marr, Adam, Filipczyk
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Dynamic deposition of the N6-methyladenosine (m6A) modification on messenger RNA (mRNA) regulates pluripotency in embryonic stem cells. Reports show that depletion of m6A abundances increases the mRNA stability of pluripotency and lineag
Autor:
Konstantinos D. Kokkaliaris, Adam Filipczyk, Felix Buggenthin, Eleni Skylaki, Timm Schroeder, Justin Feigelman, Bernhard Schauberger, Max Endele, Michael Strasser, Carsten Marr, Dirk Loeffler, Oliver Hilsenbeck, Martin Etzrodt, Philipp S. Hoppe, Fabian J. Theis, Michael Schwarzfischer, Stavroula Skylaki, Jan Krumsiek, Adrianus J J van den Berg, Simon Hastreiter
Publikováno v:
Nature Biotechnology. 34:703-706
Software tools for single-cell tracking and quantification of cellular and molecular properties
Publikováno v:
Nature methods. 14(1)
Post-transcriptional RNA modifications were discovered several decades ago, but the reversible nature of RNA modifications has only recently been discovered. Owing to technological advances, knowledge of epitranscriptomic marks and their writers, rea
Autor:
Nadine Moritz, Dirk Loeffler, Nouraiz Ahmed, Heiko Lickert, Adriana Gambardella, Martin Etzrodt, Daniel L. Coutu, Konstantinos D. Kokkaliaris, Claus Nerlov, Michael Schwarzfischer, Bernhard Schauberger, Adam Filipczyk, Michael A. Rieger, Fabian J. Theis, Olga Ermakova, Philipp S. Hoppe, Timm Schroeder, Antje Bürger, Michael Strasser, Max Endele, Ingo Burtscher, Oliver Hilsenbeck, Carsten Marr
The mechanisms underlying haematopoietic lineage decisions remain disputed. Lineage-affiliated transcription factors with the capacity for lineage reprogramming, positive auto-regulation and mutual inhibition have been described as being expressed in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a81f9763bd3ab65011ced755821495d7
https://doi.org/10.1038/nature18320
https://doi.org/10.1038/nature18320
Autor:
Fabian J. Theis, Adam Filipczyk, Carsten Marr, Timm Schroeder, Stefan Ganscha, Simon Hastreiter, Michael Schwarzfischer, Manfred Claassen, Justin Feigelman
The autoregulatory motif of Nanog, a heterogeneously expressed core pluripotency factor in mouse embryonic stem cells, remains debated. Although recent time-lapse microscopy data provide the unparalleled ability to monitor Nanog expression at the sin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66e683ea6af7ca98a19275610ba6544e
Publikováno v:
Stem Cell Research. 1(1):45-60
Mouse embryonic stem cells (mESC) exhibit cell cycle properties entirely distinct from those of somatic cells. Here we investigated the cell cycle characteristics of human embryonic stem cells (hESC). HESC could be sorted into populations based on th
Autor:
Konstantinos D. Kokkaliaris, Adam Filipczyk, Oliver Hilsenbeck, Konstantinos Anastassiadis, Bernhard Schauberger, Simon Hastreiter, Michael Schwarzfischer, Justin Feigelman, Max Endele, Fabian J. Theis, Dirk Loeffler, Philipp S. Hoppe, Stavroula Skylaki, Jan Hasenauer, Timm Schroeder, Carsten Marr
Publikováno v:
Nature cell biology. 17(10)
Transcription factor (TF) networks are thought to regulate embryonic stem cell (ESC) pluripotency. However, TF expression dynamics and regulatory mechanisms are poorly understood. We use reporter mouse ESC lines allowing non-invasive quantification o
Autor:
Simon Hastreiter, Adam Filipczyk, Manfred Claassen, Justin Feigelman, Michael Schwarzfischer, Carsten Marr, Fabian J. Theis, Stefan Ganscha, Timm Schroeder
Publikováno v:
Cell Syst. 3, 480-490 (2016)
SummaryMany cellular effectors of pluripotency are dynamically regulated. In principle, regulatory mechanisms can be inferred from single-cell observations of effector activity across time. However, rigorous inference techniques suitable for noisy, i
Autor:
Johannes Kuehle, Axel Schambach, Hannes Klump, Melanie Galla, Martijn H. Brugman, Christopher Baum, Hans R. Schöler, Stephan Halle, Timm Schroeder, Tobias Cantz, Tobias Maetzig, Adam Filipczyk, Eva Warlich
Publikováno v:
Mol. Ther. 19, 782-789 (2011)
Induced pluripotent stem cells (iPSCs) can be derived from somatic cells by gene transfer of reprogramming transcription factors. Expression levels of these factors strongly influence the overall efficacy to form iPSC colonies, but additional contrib