Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Adam F. L. Hurlstone"'
Autor:
Chun Wai Wong, Christos Evangelou, Kieran N. Sefton, Rotem Leshem, Wei Zhang, Vishaka Gopalan, Sorayut Chattrakarn, Macarena Lucia Fernandez Carro, Erez Uzuner, Holly Mole, Daniel J. Wilcock, Michael P. Smith, Kleita Sergiou, Brian A. Telfer, Dervla T. Isaac, Chang Liu, Nicholas R. Perl, Kerrie Marie, Paul Lorigan, Kaye J. Williams, Patricia E. Rao, Raghavendar T. Nagaraju, Mario Niepel, Adam F. L. Hurlstone
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Resistance mechanisms to immune checkpoint blockade therapy (ICBT) limit its response duration and magnitude. Paradoxically, Interferon γ (IFNγ), a key cytokine for cellular immunity, can promote ICBT resistance. Using syngeneic mouse tumo
Externí odkaz:
https://doaj.org/article/93f86ebcf5e046d68cb9b2272850303f
Publikováno v:
Current research in physiology. 5
Respirometry, based on oxygen uptake, is commonly employed for measuring metabolic rate. There is a growing need for metabolic rate measurements suitable for developmental studies, particularly in
Autor:
Daniel J. Wilcock, Andrew P. Badrock, Rhys Owen, Melissa Guerin, Andrew D. Southam, Hannah Johnston, Samuel Ogden, Paul Fullwood, Joanne Watson, Harriet Ferguson, Jennifer Ferguson, Daniel A. Richardson, Gavin R. Lloyd, Andris Jankevics, Warwick B. Dunn, Claudia Wellbrock, Paul Lorigan, Craig Ceol, Chiara Francavilla, Michael P. Smith, Adam F. L. Hurlstone
Dysregulated cellular metabolism is a hallmark of cancer. As yet, few druggable oncoproteins directly responsible for this hallmark have been identified. Increased fatty acid acquisition allows cancer cells to meet their membrane biogenesis, ATP, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3fe01a3cb763345ac74960293b467e5a
https://doi.org/10.1101/2020.06.23.166603
https://doi.org/10.1101/2020.06.23.166603
Autor:
Laura, Fernandez Del Ama, Mary, Jones, Paul, Walker, Anna, Chapman, Julia A, Braun, Jasmine, Mohr, Adam F L, Hurlstone
Publikováno v:
Oncotarget
Phenotype-guided re-profiling of approved drug molecules presents an accelerated route to developing anticancer therapeutics by bypassing the target-identification bottleneck of target-based approaches and by sampling drugs already in the clinic. Fur
Publikováno v:
Oncotarget
Mutations affecting Gαq proteins are pervasive in uveal melanoma (UM), suggesting they ‘drive’ UM pathogenesis. The ERK1/2-MAPK pathway is critical for cutaneous melanoma development and consequently an important therapeutic target. Defining the