Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Adam Engler"'
Autor:
Zhengming Wu, Junhui Su, Fu-long Li, Tao Chen, Jaimie Mayner, Adam Engler, Shenghong Ma, Qingquan Li, Kun-Liang Guan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Small cell lung cancer (SCLC) is highly lethal due to its prevalent metastasis. Most SCLCs have inactivating mutations in TP53 and RB1. We find that loss of YAP expression is key for SCLC cells to acquire rapid ameboid migration and high met
Externí odkaz:
https://doaj.org/article/732c3b92988d4b14a5698b812c3e72c0
Autor:
Katherine Birmingham, Benjamin Yeoman, Pranjali Beri, Jeremy Tuler, Isabelle Williams, Aditya Kumar, Sarah Klein, Parag Katira, Adam Engler
Despite better outcomes with early-stage detection, local invasion significantly reduces patient survival rates for many carcinomas. Heterogeneity within and between tumors has precluded identification of predictive biological markers, but adhesion s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11c3c197c294627c2efcdd90b17f5ffd
https://doi.org/10.21203/rs.3.rs-1498802/v1
https://doi.org/10.21203/rs.3.rs-1498802/v1
Publikováno v:
Circulation Research. 121
Despite limited regenerative capacity, compensatory mechanisms in cardiomyocytes may help maintain their function as we age, e.g. vinculin expression and localization to intercalated discs and costameres in aged organisms. This molecular mechanism, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e3cb559ed65aaee3559d73aa3cfac5d
https://doi.org/10.1161/res.121.suppl_1.127
https://doi.org/10.1161/res.121.suppl_1.127
Autor:
Aditya Kumar, Stephanie Thomas, Kirsten Wong, Valentina Lo Sardo, Daniel Cheah, Kevin Tenerelli, William Ferguson, Eric Topol, Kristin Baldwin, Adam Engler
Publikováno v:
Circulation Research. 121
Genome-wide association studies have identified single nucleotide polymorphisms (SNPs) in the non-coding 9p21 gene locus associated with increased risk of coronary artery disease (CAD) and myocardial infarction (MI). In addition, SNP correlations wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db72188acb316ea908d367653d98294d
https://doi.org/10.1161/res.121.suppl_1.289
https://doi.org/10.1161/res.121.suppl_1.289
Autor:
Cassandra Happe, Dekker Deacon, Rossin Erbe, Kevin Tenerelli, Vivien Tran, Eric Alder, Neil Chi, Adam Engler
Publikováno v:
Circulation Research. 121
Dilated cardiomyopathy (DCM) is a multivariate disease with poorly understood mechanisms, but recently 30+ different mutations have been suggested to contribute to disease pathology. We have identified the first incidence where a family with high DCM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71dfc94577ace00ee854a2124cd6648d
https://doi.org/10.1161/res.121.suppl_1.136
https://doi.org/10.1161/res.121.suppl_1.136
Publikováno v:
Biomacromolecules. 5:1908-1916
Mechanical properties of polyelectrolyte multilayer films were studied by nanoindentation using the atomic force microscope (AFM). Force-distance measurements using colloidal probe tips were systematically obtained for supported films of poly(L-lysin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::935efaf41534e6e640e4aa0267d0005d
https://doi.org/10.1021/bm0498023
https://doi.org/10.1021/bm0498023
Publikováno v:
Circulation Research. 115
An increased deposition of ECM is observed in all advanced age heart failure patients. Therefore, it is necessary to investigate the effect of extracellular remodeling on mechanical function in genetically tractable, rapidly aging, and simple model o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::796f5cc9fa51e416ae4ad249d76a64e6
https://doi.org/10.1161/res.115.suppl_1.316
https://doi.org/10.1161/res.115.suppl_1.316
Publikováno v:
Methods in cell biology. 83
In conjunction with surface chemistry, the mechanical properties of cell culture substrates provide important biological cues that affect cell behavior including growth, differentiation, spreading, and migration. The phenomenon has led to the increas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c9dd4804f659451df8393110c20e20b4
https://pubmed.ncbi.nlm.nih.gov/17613304
https://pubmed.ncbi.nlm.nih.gov/17613304