Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Adam E. Dolan"'
Autor:
Ailong Ke, Yibei Xiao, Jaewon Heo, Max J. Gramelspacher, Peter L. Freddolino, Yan Zhang, Sara E. Howden, Zhonggang Hou, Adam E. Dolan
Publikováno v:
Molecular cell. 74(5)
Summary CRISPR-Cas systems enable microbial adaptive immunity and provide eukaryotic genome editing tools. These tools employ a single effector enzyme of type II or V CRISPR to generate RNA-guided, precise genome breaks. Here we demonstrate the feasi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d296164eb58e4c82f4661c5f369cab25
https://pubmed.ncbi.nlm.nih.gov/31225749
https://pubmed.ncbi.nlm.nih.gov/31225749
Publikováno v:
Science. 361
Target degradation of Type I CRISPR The CRISPR adaptive immune systems defend bacteria against invaders. Type I CRISPR-Cas systems, the most prevalent type, use a Cascade complex to search the target DNA that is then degraded by Cas3 protein. Xiao et
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d390c2dbb26b1f50e7beeebec9254fa7
https://doi.org/10.1126/science.aat0839
https://doi.org/10.1126/science.aat0839
Autor:
Yoori Kim, Samuel D. Dahlhauser, Maxwell W. Brown, Adam E. Dolan, Logan R. Myler, Ilya J. Finkelstein, Ailong Ke, Erik T. Hernandez, Yibei Xiao, Eric V. Anslyn, Kaylee E. Dillard
Bacteria and archaea destroy foreign nucleic acids by mounting an RNA-based CRISPR-Cas adaptive immune response1–3. In type I CRISPR-Cas systems, the most frequently found type of CRISPR in bacteria and archaea3,4, foreign DNAs that trigger efficie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41904edee8bf9d7b84fb2ccb46a78aee
https://doi.org/10.1101/208058
https://doi.org/10.1101/208058
Autor:
Nicole V. Johnson, Logan R. Myler, Yoori Kim, Eric V. Anslyn, Ailong Ke, Samuel D. Dahlhauser, Erik T. Hernandez, Ilya J. Finkelstein, Kaylee E. Dillard, Maxwell W. Brown, Adam E. Dolan, Yibei Xiao
Publikováno v:
Cell. 175:934-946.e15
CRISPR-Cas systems confer an adaptive immunity against viruses. Following viral injection, Cas1-Cas2 integrates segments of the viral genome (spacers) into the CRISPR locus. In type I CRISPR-Cas systems, efficient "primed" spacer acquisition and vira
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20eff3cec66c699770162850e7b4d0ca
https://doi.org/10.1016/j.cell.2018.09.039
https://doi.org/10.1016/j.cell.2018.09.039