Zobrazeno 1 - 10
of 176
pro vyhledávání: '"Adam E Snook"'
Publikováno v:
Cancer Biology & Therapy, Vol 23, Iss 1, Pp 127-133 (2022)
The immune system is capable of remarkably potent and specific efficacy against infectious diseases. For decades, investigators sought to leverage those characteristics to create immune-based therapies (immunotherapy) that might be far more effective
Externí odkaz:
https://doaj.org/article/328838fac23e46a9807c51a48761a0db
Autor:
Maryna Perepelyuk, Chellappagounder Thangavel, Yi Liu, Robert B Den, Bo Lu, Adam E Snook, Sunday A Shoyele
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
Small interfering RNA (siRNA) is effective in silencing critical molecular pathways in cancer. The use of this tool as a treatment modality is limited by lack of an intelligent carrier system to enhance the preferential delivery of this molecule to s
Externí odkaz:
https://doaj.org/article/bf5041db9a194dffb3f432a354759d17
Autor:
Matthew E Witek, Adam E Snook, Jieru E Lin, Erik S Blomain, Bo Xiang, Michael S Magee, Scott A Waldman
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104293 (2014)
Gene expression is a dynamic and coordinated process coupling transcription with pre-mRNA processing. This regulation enables tissue-specific transcription factors to induce expression of specific transcripts that are subsequently amplified by altern
Externí odkaz:
https://doaj.org/article/f7b1b466355d4d649bcb1d8ed6148d71
Autor:
Nguyen T. Van, Karen Zhang, Rachel M. Wigmore, Anne I. Kennedy, Carolina R. DaSilva, Jialing Huang, Manju Ambelil, Jose H. Villagomez, Gerald J. O’Connor, Randy S. Longman, Miao Cao, Adam E. Snook, Michael Platten, Gerard Kasenty, Luis J. Sigal, George C. Prendergast, Sangwon V. Kim
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Environmental factors are the major contributor to the onset of immunological disorders such as ulcerative colitis. However, their identities remain unclear. Here, we discover that the amount of consumed L-Tryptophan (L-Trp), a ubiquitous di
Externí odkaz:
https://doaj.org/article/ec2a535921bc46a180d596010b048d5b
Autor:
Joshua R. Barton, Annie K. Londregan, Tyler D. Alexander, Ariana A. Entezari, Shely Bar-Ad, Lan Cheng, Angelo C. Lepore, Adam E. Snook, Manuel Covarrubias, Scott A. Waldman
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 4 (2023)
Visceral pain (VP) is a global problem with complex etiologies and limited therapeutic options. Guanylyl cyclase C (GUCY2C), an intestinal receptor producing cyclic GMP(cGMP), which regulates luminal fluid secretion, has emerged as a therapeutic targ
Externí odkaz:
https://doaj.org/article/6fcd4bf1e4cf498abeccb887b46d04f2
Autor:
John C. Flickinger, Ross E. Staudt, Jagmohan Singh, Robert D. Carlson, Joshua R. Barton, Trevor R. Baybutt, Jeffrey A. Rappaport, Alicja Zalewski, Amanda Pattison, Scott A. Waldman, Adam E. Snook
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-10 (2022)
Abstract Strategies to augment immunity to self/neoantigens expressed by cancers are urgently needed to expand the proportion of patients benefiting from immunotherapy, particularly for GI cancers where only a fraction of patients respond to immunoth
Externí odkaz:
https://doaj.org/article/e22b2a072d4641808bb7b166089c9d83
Autor:
Babar Bashir, Adam E. Snook
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 14, Iss 2, Pp 250-254 (2018)
Metastatic colorectal cancer (mCRC) is a leading cause of cancer-related mortality with a 5-year overall survival rate of 13%. Despite recent advances in cancer immunotherapy, only the minority of CRC patients (
Externí odkaz:
https://doaj.org/article/f87cb79a81bb482886777194a8cba689
Publikováno v:
Expert Review of Clinical Pharmacology. 15:1317-1326
Colorectal cancer (CRC) is the second most common cause of cancer-related death worldwide. Although overall survival for CRC patients has improved with earlier screening, survival continues to vary substantially across stages. Also, while the introdu
Autor:
Adam E. Snook, Scott A. Waldman, Adam R. Hersperger, Priyanka Prajapati, Glen P. Marszalowicz, Natalie A. Ridge, John C. Flickinger, Trevor R. Baybutt, Tara S. Abraham, Michael S. Magee
Figure S11 shows that hGUCY2C-specific 5F9.m28BBz CAR-T cells do not recognize murine GUCY2C.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03c5b99dc4205587ea934681006c7eb7
https://doi.org/10.1158/2326-6066.22536559.v1
https://doi.org/10.1158/2326-6066.22536559.v1