Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Adam E Mullick"'
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 4, Iss C (2015)
Preclinical and clinical data suggest CD40 activation contributes to renal inflammation and injury. We sought to test whether upregulation of CD40 in the kidney is a causative factor of renal pathology and if reduction of renal CD40 expression, using
Externí odkaz:
https://doaj.org/article/7d580cead0ee4bb8bf6901d073fb5063
Autor:
Shayan Mohammadmoradi, Hisashi Sawada, Sohei Ito, Adam E. Mullick, Deborah A. Howatt, Michael Franklin, Hong S. Lu, Alan Daugherty
Publikováno v:
JVS - Vascular Science, Vol 4, Iss , Pp 100161- (2023)
Externí odkaz:
https://doaj.org/article/f50d2489fcbb441e8cecdffa18fc3285
Autor:
Jackie M. Zhang, Dianaly T. Au, Hisashi Sawada, Michael K. Franklin, Jessica J. Moorleghen, Deborah A. Howatt, Pengjun Wang, Brittany O. Aicher, Brian Hampton, Mary Migliorini, Fenge Ni, Adam E. Mullick, Mashhood M. Wani, Areck A. Ucuzian, Hong S. Lu, Selen C. Muratoglu, Alan Daugherty, Dudley K. Strickland
Publikováno v:
JCI Insight, Vol 8, Iss 2 (2023)
Vascular smooth muscle cells (vSMCs) exert a critical role in sensing and maintaining vascular integrity. These cells abundantly express the low-density lipoprotein receptor–related protein 1 (LRP1), a large endocytic signaling receptor that recogn
Externí odkaz:
https://doaj.org/article/ed0a8984fa804ee7ba6b0ca5af6a4865
Autor:
Jide Oluwadare, Ainara G. Cabodevilla, Ni-Huiping Son, Yunying Hu, Adam E. Mullick, Michael Verano, Jose O. Alemán, Ravichandran Ramasamy, Ira J. Goldberg
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 11, Pp 100274- (2022)
Lipid accumulation in nonadipose tissues can cause lipotoxicity, leading to cell death and severe organ dysfunction. Adipose triglyceride lipase (ATGL) deficiency causes human neutral lipid storage disease and leads to cardiomyopathy; ATGL deficiency
Externí odkaz:
https://doaj.org/article/f665ac1d40554a758d5215f1f0e19a98
Autor:
Niels Grote Beverborg, Daniela Später, Ralph Knöll, Alejandro Hidalgo, Steve T. Yeh, Zaher Elbeck, Herman H. W. Silljé, Tim R. Eijgenraam, Humam Siga, Magdalena Zurek, Malin Palmér, Susanne Pehrsson, Tamsin Albery, Nils Bomer, Martijn F. Hoes, Cornelis J. Boogerd, Michael Frisk, Eva van Rooij, Sagar Damle, William E. Louch, Qing-Dong Wang, Regina Fritsche-Danielson, Kenneth R. Chien, Kenny M. Hansson, Adam E. Mullick, Rudolf A. de Boer, Peter van der Meer
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Heart failure is a major cause of morbidity and mortality worldwide. Here the authors show that subcutaneous administration of antisense oligonucleotides targeting PLN is an effective strategy in preclinical models of genetic cardiomyopathy and ische
Externí odkaz:
https://doaj.org/article/fe3711b0c9be44609d25d2ed5e1f2344
Autor:
Bastian Ramms, Sohan Patel, Xiaoli Sun, Ariane R. Pessentheiner, G. Michelle Ducasa, Adam E. Mullick, Richard G. Lee, Rosanne M. Crooke, Sotirios Tsimikas, Joseph L. Witztum, Philip L.S.M. Gordts
Publikováno v:
JCI Insight, Vol 7, Iss 13 (2022)
Apolipoprotein C-III (apoC-III) is a critical regulator of triglyceride metabolism and correlates positively with hypertriglyceridemia and cardiovascular disease (CVD). It remains unclear if therapeutic apoC-III lowering reduces CVD risk and if the C
Externí odkaz:
https://doaj.org/article/d3c85ea05ac64087a50365d3f59dcc54
Autor:
Dien Ye, Xiaofei Yang, Liwei Ren, Hong S. Lu, Yuan Sun, Hui Lin, Lunbo Tan, Na Wang, Genevieve Nguyen, Michael Bader, Adam E. Mullick, A. H. Jan Danser, Alan Daugherty, Yizhou Jiang, Yidan Sun, Furong Li, Xifeng Lu
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Objective: Elevated plasma cholesterol concentrations contributes to ischemic cardiovascular diseases. Recently, we showed that inhibiting hepatic (pro)renin receptor [(P)RR] attenuated diet-induced hypercholesterolemia and hypertriglyceridemia in lo
Externí odkaz:
https://doaj.org/article/9afa4c3acbca4a4285530bd6e4d40d51
Publikováno v:
Biomedicines, Vol 10, Iss 7, p 1635 (2022)
Nanoparticles (NPs) can enable delivery of a drug to a targeted tissue. Previous studies have shown that an NP utilizing an adipose targeting sequence (ATS) peptide in conjunction with a drug can selectively deliver the drug to mouse adipose tissues,
Externí odkaz:
https://doaj.org/article/5e2a252f95e043cabf1562f1f152c61c
Blood Levels of Angiotensinogen and Hypertension in the Multi-Ethnic Study of Atherosclerosis (MESA)
Autor:
Patrick J. Trainor, Michela Brambatti, Samantha M. Carlisle, Adam E. Mullick, Sanjiv J. Shah, Tanvir Kahlon, Diana Otero Mostacero, Hossein Mousavi, Erin S. Morgan, Yvonne Tami, Erin D. Michos, Pamela Ouyang, Sotirios Tsimikas, Andrew P. DeFilippis
Publikováno v:
Journal of the American College of Cardiology. 81:1248-1259
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3391773905c5f6f95ff9b1b40025516c
https://doi.org/10.1016/j.jacc.2023.01.033
https://doi.org/10.1016/j.jacc.2023.01.033
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100076- (2021)
Externí odkaz:
https://doaj.org/article/57d41a9cdaac48e5b50d4554b52bbc3e