Sialic acid blockade inhibits the metastatic spread of prostate cancer to boneResearch in context

Autor: Kirsty Hodgson, Margarita Orozco-Moreno, Emily Archer Goode, Matthew Fisher, Rebecca Garnham, Richard Beatson, Helen Turner, Karen Livermore, Yuhan Zhou, Laura Wilson, Eline A. Visser, Johan FA. Pijnenborg, Nienke Eerden, Sam J. Moons, Emiel Rossing, Gerald Hysenaj, Rashi Krishna, Ziqian Peng, Kyla Putri Nangkana, Edward N. Schmidt, Adam Duxfield, Ella P. Dennis, Rakesh Heer, Michelle A. Lawson, Matthew Macauley, David J. Elliott, Christian Büll, Emma Scott, Thomas J. Boltje, Richard R. Drake, Ning Wang, Jennifer Munkley

Publikováno v: EBioMedicine, Vol 104, Iss , Pp 105163- (2024)

Summary: Background: Bone metastasis is a common consequence of advanced prostate cancer. Bisphosphonates can be used to manage symptoms, but there are currently no curative treatments available. Altered tumour cell glycosylation is a hallmark of can

Externí odkaz: https://doaj.org/article/afcff439ec0a4487aa2daaa9f610248c

Upregulation of GALNT7 in prostate cancer modifies O-glycosylation and promotes tumour growth

Autor: Emma Scott, Kirsty Hodgson, Beatriz Calle, Helen Turner, Kathleen Cheung, Abel Bermudez, Fernando Jose Garcia Marques, Hayley Pye, Edward Christopher Yo, Khirul Islam, Htoo Zarni Oo, Urszula L. McClurg, Laura Wilson, Huw Thomas, Fiona M. Frame, Margarita Orozco-Moreno, Kayla Bastian, Hector M. Arredondo, Chloe Roustan, Melissa Anne Gray, Lois Kelly, Aaron Tolson, Ellie Mellor, Gerald Hysenaj, Emily Archer Goode, Rebecca Garnham, Adam Duxfield, Susan Heavey, Urszula Stopka-Farooqui, Aiman Haider, Alex Freeman, Saurabh Singh, Edward W. Johnston, Shonit Punwani, Bridget Knight, Paul McCullagh, John McGrath, Malcolm Crundwell, Lorna Harries, Denisa Bogdan, Daniel Westaby, Gemma Fowler, Penny Flohr, Wei Yuan, Adam Sharp, Johann de Bono, Norman J. Maitland, Simon Wisnovsky, Carolyn R. Bertozzi, Rakesh Heer, Ramon Hurtado Guerrero, Mads Daugaard, Janne Leivo, Hayley Whitaker, Sharon Pitteri, Ning Wang, David J. Elliott, Benjamin Schumann, Jennifer Munkley

Publikováno v: Scott, E, Hodgson, K, Calle, B, Turner, H, Cheung, K, Bermudez, A, Marques, F J G, Pye, H, Yo, E C, Islam, K, Oo, H Z, McClurg, U L, Wilson, L, Thomas, H, Frame, F M, Orozco-Moreno, M, Bastian, K, Arredondo, H M, Roustan, C, Gray, M A, Kelly, L, Tolson, A, Mellor, E, Hysenaj, G, Goode, E A, Garnham, R, Duxfield, A, Heavey, S, Stopka-Farooqui, U, Haider, A, Freeman, A, Singh, S, Johnston, E W, Punwani, S, Knight, B, McCullagh, P, McGrath, J, Crundwell, M, Harries, L, Bogdan, D, Westaby, D, Fowler, G, Flohr, P, Yuan, W, Sharp, A, de Bono, J, Maitland, N J, Wisnovsky, S, Bertozzi, C R, Heer, R, Guerrero, R H, Daugaard, M, Leivo, J, Whitaker, H, Pitteri, S, Wang, N, Elliott, D J, Schumann, B & Munkley, J 2023, ' Upregulation of GALNT7 in prostate cancer modifies O-glycosylation and promotes tumour growth ', Oncogene, vol. 42, pp. 926–937 . https://doi.org/10.1038/s41388-023-02604-x

Prostate cancer is the most common cancer in men and it is estimated that over 350,000 men worldwide die of prostate cancer every year. There remains an unmet clinical need to improve how clinically significant prostate cancer is diagnosed and develo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae09a3648b677fb4f00e9f89464d3260

CRELD2 is a novel modulator of calcium mobilisation and calcineurin- NFAT signalling during osteoclast differentiation

Autor: Adam Duxfield, Jennifer Munkley, Michael D. Briggs, Ella P. Dennis

Cysteine rich with epidermal growth factor (EGF)-like domains 2 (CRELD2) is an endoplasmic reticulum (ER) resident chaperone protein with calcium binding properties. CRELD2 is an ER-stress regulated gene that has been implicated in the pathogenesis o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6775aaa755ccef3b6080ccb9a8f8ab08
https://doi.org/10.21203/rs.3.rs-1435321/v1