Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Adam D. Shilling"'
Autor:
Raymond T. Camphausen, Cheryl Nickerson-Nutter, Desiree H.H. Tsao, Neelu Kaila, Adam D. Shilling, Ruth Young-Sciame, Silvano DeBernardo, Patricia W. Bedard, Kristin Janz, Qin Wang, Tam Steve Yik-Kai, James C. Keith
Publikováno v:
Journal of Medicinal Chemistry. 50:21-39
Leukocyte recruitment of sites of inflammation and tissue injury involves leukocyte rolling along the endothelial wall, followed by firm adherence of the leukocyte, and finally transmigration of the leukocyte across cell junctions into the underlying
Autor:
Shendi Lu, Lynn Resnick, Jean Zhang, Stacey J. Sukoff Rizzo, Chad E. Beyer, Sharon Rosenzweig-Lipson, Dianne Kowal, Jianyao Wang, Deborah L. Smith, Claudine Pulicicchio, Liza Leventhal, Caitlin Wantuch, John A. Butera, Corey N. Bender, Adam D. Shilling, Terri Cummons, Lee E. Schechter, Jason M. Dwyer, Mei-Yi Zhang, Brian J. Platt, S. Johannes R. Rajarao
Publikováno v:
The international journal of neuropsychopharmacology. 13(9)
Biogenic amines such as norepinephrine, dopamine, and serotonin play a well-described role in the treatment of mood disorders and some types of pain. As alpha2A-adrenoceptors regulate the release of these neurotransmitters, we examined the therapeuti
Autor:
Lo Jennifer Rebecca, Terrance H. Andree, Deborah Ann Evrard, Adam D. Shilling, Nicole T. Hatzenbuhler, Gary Paul Stack, Qian Lin, Deborah L. Smith, Megan Tran, Jeannette Golembieski, P J Mitchell, Lee E. Schechter, Chad E. Beyer, Dahui Zhou, Christine Huselton, Margaret Lai, Geoffrey Hornby, Boyd L. Harrison, Susan Christman Croce, Amedeo Arturo Failli, Soo Y. Yi
Publikováno v:
Journal of medicinal chemistry. 52(15)
On the basis of the previously reported clinical candidate, SSA-426 (1), a series of related 2-piperazin-1-ylquinoline derivatives 3-16 were synthesized and evaluated as dual-acting serotonin (5-HT) reuptake inhibitors and 5-HT1A receptor antagonists
Autor:
Aram, Oganesian, Adam D, Shilling, Ruth, Young-Sciame, Judy, Tran, Adiba, Watanyar, Farooq, Azam, John, Kao, Louis, Leung
Publikováno v:
Psychopharmacology bulletin. 42(2)
Identification of potential pharmacokinetic drug-drug interactions is an important step in clinical drug development.We assessed and compared the drug-drug interaction potential of desvenlafaxine and venlafaxine, based on their inhibitory potency on
Autor:
Douglas P. Wilson, Diane Joseph-McCarthy, Weixin Xu, Junjun Wu, Eva Binnun, James Tobin, Min Zhu, David V. Erbe, Adam D. Shilling, Jinbo Lee, Louis Leung, Yan-Ling Zhang, Zhao-Kui Wan, Kenneth W. Foreman, Steven J. Kirincich, Xin Xu, Alessandro Moretto, Bruce Follows, Tam Steve Yik-Kai, May Tam, Tarek S. Mansour
Publikováno v:
Journal of medicinal chemistry. 50(19)
Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of the insulin and leptin receptor pathways and thus an attractive therapeutic target for diabetes and obesity. Starting with a high micromolar lead compound, structure-based optimizatio
Publikováno v:
Toxicology and applied pharmacology. 170(3)
Indole-3-carbinol (I3C), a compound found in Brassica vegetables has been widely studied for its chemopreventive properties. I3C has been shown to block tumor initiation and promotion; however, it also acts as a tumor promoter. I3C and some of its ac
Autor:
Dahui Zhou, Gary P. Stack, Jennifer Lo, Amedeo A. Failli, Deborah A. Evrard, Boyd L. Harrison, Nicole T. Hatzenbuhler, Megan Tran, Susan Croce, Soo Yi, Jeannette Golembieski, Geoffrey A. Hornby, Margaret Lai, Qian Lin, Lee E. Schechter, Deborah L. Smith, Adam D. Shilling, Christine Huselton, Paul Mitchell, Chad E. Beyer
Publikováno v:
Journal of Medicinal Chemistry; Aug2009, Vol. 52 Issue 15, p4955-4959, 5p
Publikováno v:
Drug Metabolism Reviews. 2002 Supplement 1, Vol. 34, p90-90. 1/2p.
Autor:
Unwalla, Rayomand J.1 unwallr@wyeth.com, Cross, Jason B.2, Salaniwal, Sumeet3, Shilling, Adam D.4, Leung, Louis4, Kao, John4, Humblet, Christine5
Publikováno v:
Journal of Computer-Aided Molecular Design. Mar2010, Vol. 24 Issue 3, p237-256. 20p. 10 Diagrams, 5 Charts, 2 Graphs.
Publikováno v:
Drug Metabolism Reviews. Nov2009 Supplement 3, Vol. 41, p7-186. 180p. 11 Diagrams, 6 Charts.