Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Adam D. Kenney"'
Autor:
Samuel Speaks, Matthew I. McFadden, Ashley Zani, Abigail Solstad, Steve Leumi, Jack E. Roettger, Adam D. Kenney, Hannah Bone, Lizhi Zhang, Parker J. Denz, Adrian C. Eddy, Amal O. Amer, Richard T. Robinson, Chuanxi Cai, Jianjie Ma, Emily A. Hemann, Adriana Forero, Jacob S. Yount
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Influenza virus activates cellular inflammasome pathways, which can be both beneficial and detrimental to infection outcomes. Here, we investigate the function of the inflammasome-activated, pore-forming protein gasdermin D (GSDMD) during in
Externí odkaz:
https://doaj.org/article/1bdb4d643c5340eaab89b6eb41184ba9
Autor:
Guoli Shi, Abhilash I. Chiramel, Tiansheng Li, Kin Kui Lai, Adam D. Kenney, Ashley Zani, Adrian C. Eddy, Saliha Majdoul, Lizhi Zhang, Tirhas Dempsey, Paul A. Beare, Swagata Kar, Jonathan W. Yewdell, Sonja M. Best, Jacob S. Yount, Alex A. Compton
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 24 (2022)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in immunocompromised individuals is associated with prolonged virus shedding and evolution of viral variants. Rapamycin and its analogs (rapalogs, including everolimus, temsirolim
Externí odkaz:
https://doaj.org/article/54c02ef4c7e14f2d8fd82a8b248817d9
Autor:
Georgios I. Laliotis, Adam D. Kenney, Evangelia Chavdoula, Arturo Orlacchio, Abdul Kaba, Alessandro La Ferlita, Vollter Anastas, Christos Tsatsanis, Joal D. Beane, Lalit Sehgal, Vincenzo Coppola, Jacob S. Yount, Philip N. Tsichlis
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
Laliotis et al. examine the role of the AKT3-phoshorylated RNA processing factor IWS1 and the IWS1 phosphorylation-dependent alternative splicing of U2AF2 in lung adenocarcinoma cells. The alternatively spliced variant of U2AF2 regulates the nuclear
Externí odkaz:
https://doaj.org/article/4976aacb26fc469e84b6096ba7b23887
Autor:
Tai-Wei Li, Adam D. Kenney, Jun-Gyu Park, Guillaume N. Fiches, Helu Liu, Dawei Zhou, Ayan Biswas, Weiqiang Zhao, Jianwen Que, Netty Santoso, Luis Martinez-Sobrido, Jacob S. Yount, Jian Zhu
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection leads to NF-κB activation and induction of pro-inflammatory cytokines, though the underlying mechanism for this activation is not fully understood. Our results reveal that the SA
Externí odkaz:
https://doaj.org/article/92359d42839349c18b69b00619ad6b06
Autor:
Matthew Sermersheim, Adam D. Kenney, Pei-Hui Lin, Temet M. McMichael, Chuanxi Cai, Kristyn Gumpper, T. M. Ayodele Adesanya, Haichang Li, Xinyu Zhou, Ki-Ho Park, Jacob S. Yount, Jianjie Ma
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
TRIM proteins are known to play critical roles in the context of viral infection. Here the authors establish MG53 (TRIM72) suppresses IFN and inflammation by modulation of ryanodine receptor related intracellular calcium induction.
Externí odkaz:
https://doaj.org/article/6597955c13bc4dd2bb5688a5b442a740
Autor:
Georgios I. Laliotis, Adam D. Kenney, Evangelia Chavdoula, Arturo Orlacchio, Abdul Kaba, Alessandro La Ferlita, Vollter Anastas, Christos Tsatsanis, Joal D. Beane, Lalit Sehgal, Vincenzo Coppola, Jacob S. Yount, Philip N. Tsichlis
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/859053680f90418f9f1e997cd1ac2603
Autor:
Joseph S. Bednash, Finny Johns, Daniela Farkas, Ajit Elhance, Jessica Adair, Kirstin Cress, Jacob S. Yount, Adam D. Kenney, James D. Londino, Rama K. Mallampalli
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 68:566-576
Autor:
Adam D Kenney, Ashley Zani, Jeffrey Kawahara, Adrian C Eddy, Xiao‐Liang Wang, KC Mahesh, Mijia Lu, Jeronay Thomas, Jacob E Kohlmeier, Mehul S Suthar, Emily A Hemann, Jianrong Li, Mark E Peeples, Luanne Hall‐Stoodley, Adriana Forero, Chuanxi Cai, Jianjie Ma, Jacob S Yount
Publikováno v:
EMBO reports. 24
Autor:
Mostafa M. Eltobgy, Ashley Zani, Adam D. Kenney, Shady Estfanous, Eunsoo Kim, Asmaa Badr, Cierra Carafice, Kylene Daily, Owen Whitham, Maciej Pietrzak, Amy Webb, Jeffrey Kawahara, Adrian C. Eddy, Parker Denz, Mijia Lu, Mahesh KC, Mark E. Peeples, Jianrong Li, Jian Zhu, Jianwen Que, Richard Robinson, Oscar Rosas Mejia, Rachael E. Rayner, Luanne Hall-Stoodley, Stephanie Seveau, Mikhail A. Gavrilin, Xiaoli Zhang, Jeronay Thomas, Jacob E. Kohlmeier, Mehul S. Suthar, Eugene Oltz, Andrea Tedeschi, Frank H. Robledo-Avila, Santiago Partida-Sanchez, Emily A. Hemann, Eman Abdelrazik, Adriana Forero, Shahid M. Nimjee, Prosper N. Boyaka, Estelle Cormet-Boyaka, Jacob S. Yount, Amal O. Amer
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(21)
Severe acute respiratory syndrome coronavirus 2 (SARS–CoV-2) is a worldwide health concern, and new treatment strategies are needed. Targeting inflammatory innate immunity pathways holds therapeutic promise, but effective molecular targets remain e
Autor:
Chuanxi Cai, Jianjie Ma, Adam D. Kenney, Xinyu Zhou, Tao Tan, Zhongguang Li, Zehua Bian, Bryan A. Whitson, Jacob S. Yount, Haichang Li
Publikováno v:
Am J Respir Crit Care Med