Altered dendritic spine function and integration in a mouse model of fragile X syndrome

Autor: Sam A. Booker, Aleksander P. F. Domanski, Owen R. Dando, Adam D. Jackson, John T. R. Isaac, Giles E. Hardingham, David J. A. Wyllie, Peter C. Kind

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

Fragile X syndrome and autism spectrum disorders are associated with circuit hyperexcitability, however, its cellular and synaptic bases are not well understood. Here, the authors report abnormal synaptogenesis with an increased prevalence of polysyn

Externí odkaz: https://doaj.org/article/2fbc40b23b8f4722ab1014116cebc102

Imbalance of flight–freeze responses and their cellular correlates in the Nlgn3−/y rat model of autism

Autor: Natasha J. Anstey, Vijayakumar Kapgal, Shashank Tiwari, Thomas C. Watson, Anna K. H. Toft, Owen R. Dando, Felicity H. Inkpen, Paul S. Baxter, Zrinko Kozić, Adam D. Jackson, Xin He, Mohammad Sarfaraz Nawaz, Aiman Kayenaat, Aditi Bhattacharya, David J. A. Wyllie, Sumantra Chattarji, Emma R. Wood, Oliver Hardt, Peter C. Kind

Publikováno v: Anstey, N J, Kapgal, V, Tiwari, S, Watson, T C, Toft, A K H, Dando, O R, Inkpen, F H, Baxter, P S, Kozic, Z, Jackson, A D, He, X, Nawaz, M S, Kayenaat, A, Bhattacharya, A, Wyllie, D J A, Chattarji, S, Wood, E R, Hardt, O & Kind, P C 2022, ' Imbalance of flight-freeze responses and their cellular correlates in the Nlgn3-/y rat model of autism ', Molecular Autism, vol. 13, 34 . https://doi.org/10.1186/s13229-022-00511-8

BackgroundMutations in the postsynaptic transmembrane protein neuroligin-3 are highly correlative with autism spectrum disorders (ASDs) and intellectual disabilities (IDs). Fear learning is well studied in models of these disorders, however differenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02c236db287e28b698524b9c96f2a988
https://doi.org/10.1186/s13229-022-00511-8

Altered dendritic spine function and integration in a mouse model of fragile X syndrome

Autor: Peter C. Kind, Sam A. Booker, Giles E. Hardingham, John T.R. Isaac, Aleksander P. F. Domanski, Owen Dando, David J. A. Wyllie, Adam D. Jackson

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Booker, S A, Domanski, A P F, Dando, O R, Jackson, A D, Isaac, J T R, Hardingham, G E, Wyllie, D J A & Kind, P C 2019, ' Altered dendritic spine function and integration in a mouse model of fragile X syndrome ', Nature Communications, vol. 10, 4813 (2019) . https://doi.org/10.1038/s41467-019-11891-6
Booker, S A, Domanski, A P F, Dando, O R, Jackson, A D, Isaac, J T R, Hardingham, G E, Wyllie, D J A & Kind, P C 2019, ' Altered dendritic spine function and integration in a mouse model of fragile X syndrome ', Nature Communications, vol. 10, 4813 . https://doi.org/10.1038/s41467-019-11891-6
Nature Communications

Cellular and circuit hyperexcitability are core features of fragile X syndrome and related autism spectrum disorder models. However, the cellular and synaptic bases of this hyperexcitability have proved elusive. We report in a mouse model of fragile

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4882e3461e4f8fa36cb97031a008375d
http://link.springer.com/article/10.1038/s41467-019-11891-6

Input-Output Relationship of CA1 Pyramidal Neurons Reveals Intact Homeostatic Mechanisms in a Mouse Model of Fragile X Syndrome

Autor: Giles E. Hardingham, Sam A. Booker, Peter J. Brophy, Lori L. Isom, Peter C. Kind, Natasha J. Anstey, Owen Dando, Paul Baxter, Zrinko Kozic, Diane L. Sherman, David J. A. Wyllie, Adam D. Jackson, Laura Simões de Oliveira

Publikováno v: Cell Reports
Cell Reports, Vol 32, Iss 6, Pp 107988-(2020)
Booker, S, Simões De Oliveira, L, Anstey, N, Kozic, Z, Dando, O, Jackson, A, Baxter, P, Isom, L L, Sherman, D, Hardingham, G, Brophy, P, Wyllie, D & Kind, P 2020, ' Input-output relationship of CA1 pyramidal neurons reveals intact homeostatic mechanisms in a mouse model of Fragile X Syndrome ', Cell Reports . https://doi.org/10.1016/j.celrep.2020.107988

Summary Cellular hyperexcitability is a salient feature of fragile X syndrome animal models. The cellular basis of hyperexcitability and how it responds to changing activity states is not fully understood. Here, we show increased axon initial segment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f9797275eb9aaa429ebde97331a1a50
http://europepmc.org/articles/PMC7435362

Convergence of Hippocampal Pathophysiology inSyngap+/−andFmr1−/yMice

Autor: U. Valentin Nägerl, Emily K. Osterweil, Lasani S. Wijetunge, Noboru H. Komiyama, Danai Katsanevaki, Seth G. N. Grant, Peter C. Kind, David J. A. Wyllie, Stephanie A. Barnes, Adam D. Jackson, Mark F. Bear

Publikováno v: Barnes, S A, Wijetunge, L S, Jackson, A D, Katsanevaki, D, Osterweil, E K, Komiyama, N H, Grant, S G N, Bear, M F, Nägerl, U V, Kind, P C & Wyllie, D J A 2015, ' Convergence of hippocampal pathophysiology in Syngap +/-and Fmr1-/y mice ', Journal of Neuroscience, vol. 35, no. 45, pp. 15073-15081 . https://doi.org/10.1523/JNEUROSCI.1087-15.2015

Previous studies have hypothesized that diverse genetic causes of intellectual disability (ID) and autism spectrum disorders (ASDs) converge on common cellular pathways. Testing this hypothesis requires detailed phenotypic analyses of animal models w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69d0ef4ddbeb9ef666bce91602aa6ea1
https://doi.org/10.1523/jneurosci.1087-15.2015