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pro vyhledávání: '"Adam D. Hines"'
SummaryGeneral anesthetics disrupt brain network dynamics through multiple pathways, predominately through post-synaptic potentiation of GABAAR and pre-synaptic inhibition of neuroexocytosis. Common clinical general anesthetic drugs, such as propofol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b629e90af49040c72987f8a02bbc0cc
https://doi.org/10.1101/2023.02.27.530184
https://doi.org/10.1101/2023.02.27.530184
Pharmacological activation of IKr in models of long QT Type 2 risks overcorrection of repolarization
Autor:
Melissa M Mangala, Timothy Y M Ng, Jamie I. Vandenberg, Matthew D. Perry, Adam D Hines, Whitney Liang, Chai Ann Ng, Michelle J O Xu, Adam P. Hill
Publikováno v:
Cardiovascular Research. 116:1434-1445
Aims Current treatment for congenital long QT syndrome Type 2 (cLQTS2), an electrical disorder that increases the risk of life-threatening cardiac arrhythmias, is aimed at reducing the incidence of arrhythmia triggers (beta-blockers) or terminating t
Autor:
Adam D, Hines, Bruno, van Swinderen
Publikováno v:
eNeuro
Visual Abstract
Super-resolution microscopy provides valuable insight for understanding the nanoscale organization within living tissue, although this method is typically restricted to cultured or dissociated cells. Here, we develop a method to
Super-resolution microscopy provides valuable insight for understanding the nanoscale organization within living tissue, although this method is typically restricted to cultured or dissociated cells. Here, we develop a method to
Autor:
Adam D Hines, Bruno van Swinderen
Super-resolution microscopy provides valuable insight for understanding the nanoscale organization within living tissue, although this method is typically restricted to cultured or dissociated cells. Here, we develop a method to track the mobility of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff84e33d2f7eb07fe8ddd33c02e9140a
https://doi.org/10.1101/2020.09.18.303818
https://doi.org/10.1101/2020.09.18.303818
Autor:
Adam D Hines, Bruno van Swinderen
Publikováno v:
eneuro. 8:ENEURO.0057-21.2021
Super-resolution microscopy provides valuable insight for understanding the nanoscale organization within living tissue, although this method is typically restricted to cultured or dissociated cells. Here, we develop a method to track the mobility of
Autor:
Bruno van Swinderen, Adam D Hines
Publikováno v:
Proceedings of the National Academy of Sciences. 117:24627-24628
A recent study (1) uses Drosophila flies to support a mechanism for general anesthesia. The authors find a specific effect on TWIK-related K+ (TREK-1) channels (a class of potassium leak channels) that results from a nonspecific effect on cholesterol