Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Adam D. Grant"'
Autor:
Adam W. Watson, Adam D. Grant, Sara S. Parker, Samantha Hill, Michael B. Whalen, Jayati Chakrabarti, Michael W. Harman, Mackenzie R. Roman, Brittany L. Forte, Cody C. Gowan, Raúl Castro-Portuguez, Lindsey K. Stolze, Christian Franck, Darren A. Cusanovich, Yana Zavros, Megha Padi, Casey E. Romanoski, Ghassan Mouneimne
Publikováno v:
Cell Reports, Vol 35, Iss 13, Pp 109293- (2021)
Summary: While the immediate and transitory response of breast cancer cells to pathological stiffness in their native microenvironment has been well explored, it remains unclear how stiffness-induced phenotypes are maintained over time after cancer c
Externí odkaz:
https://doaj.org/article/9120a5dd6d85476791e874d67897611c
Publikováno v:
Frontiers in Genetics, Vol 11 (2021)
The use of biological networks such as protein–protein interaction and transcriptional regulatory networks is becoming an integral part of genomics research. However, these networks are not static, and during phenotypic transitions like disease ons
Externí odkaz:
https://doaj.org/article/76ef5d723cda4c48859cbf5fd0d5079b
Autor:
Sara S. Parker, Kenneth Tran Ly, Adam D. Grant, Jillian Sweetland, Ashley M. Wang, James D. Parker, Mackenzie R. Roman, Kathylynn Saboda, Denise J. Roe, Megha Padi, Charles W. Wolgemuth, Paul Langlais, Ghassan Mouneimne
Publikováno v:
Journal of Cell Biology. 222
Dendritic spines are the postsynaptic compartment of a neuronal synapse and are critical for synaptic connectivity and plasticity. A developmental precursor to dendritic spines, dendritic filopodia (DF), facilitate synapse formation by sampling the e
Autor:
Megha Padi, Wang Am, Ghassan Mouneimne, Parker Jd, Ly Kt, Charles W. Wolgemuth, Mackenzie R. Roman, Paul R. Langlais, Sara S. Parker, Adam D. Grant
Dendritic spines are the postsynaptic compartment of a functional neuronal synapse, and are critical for synaptic connectivity and plasticity. The developmental precursor to dendritic spines, dendritic filopodia, are highly motile protrusions that fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51a608162f2f7b18e10b5aebf6409a17
https://doi.org/10.1101/2021.05.26.444586
https://doi.org/10.1101/2021.05.26.444586
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific Reports
Scientific Reports
Genetic alterations are essential for cancer initiation and progression. However, differentiating mutations that drive the tumor phenotype from mutations that do not affect tumor fitness remains a fundamental challenge in cancer biology. To better un
Autor:
Amanda Ruiz, Tun Jie, Agnieszka K. Witkiewicz, Erik S. Knudsen, Shailender S. Chauhan, Vishnu Kumarasamy, Taylor S. Riall, Paris Vail, Sejin Chung, Adam D. Grant, Jared Sivinski
Publikováno v:
Oncogene
Pancreatic ductal adenocarcinoma (PDAC), like many KRAS-driven tumors, preferentially loses CDKN2A that encodes an endogenous CDK4/6 inhibitor to bypass the RB-mediated cell cycle suppression. Analysis of a panel of patient-derived cell lines and mat
ObjectivesPreliminary genomic analysis of primary pancreatic neuroendocrine tumors revealed a complex mutational landscape with four common oncogenic events; however, critical activation pathways responsible for pancreatic neuroendocrine tumor progre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23b6a15629224ad27cafdd4c3fd2cf13
https://doi.org/10.1101/2020.09.29.318873
https://doi.org/10.1101/2020.09.29.318873
Autor:
Lindsey K. Stolze, Casey E. Romanoski, Adam W. Watson, Ghassan Mouneimne, Sara S. Parker, Megha Padi, Darren A. Cusanovich, Michael W. Harman, Christian Franck, Raul Castro-Portuguez, Mackenzie R. Roman, Brittany L. Uhlorn, Cody C. Gowan, Adam D. Grant
Publikováno v:
SSRN Electronic Journal.
The mechanical microenvironment of primary breast tumors plays a substantial role in promoting tumor progression1. While the transitory response of cancer cells to pathological stiffness in their native microenvironment has been well described2, it i
Autor:
Mackenzie R. Roman, Cody C. Gowan, Sara S. Parker, Adam W. Watson, Ghassan Mouneimne, Michael W. Harman, Megha Padi, Christian Franck, Darren A. Cusanovich, Raul Castro-Portuguez, Casey E. Romanoski, Adam D. Grant, Brittany L. Forte
The mechanical microenvironment of primary breast tumors plays a substantial role in promoting tumor progression. While the transitory response of cancer cells to pathological stiffness in their native microenvironment has been well described, it is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::835d09c3401706559971aca9f95bc0c8
Autor:
Megha Padi, Adam D. Grant, Casey E. Romanoski, Samantha M. Hill, Darren A. Cusanovich, Michael B. Whalen, Mackenzie R. Roman, Michael W. Harman, Yana Zavros, Adam W. Watson, Cody C. Gowan, Sara S. Parker, Ghassan Mouneimne, Brittany L. Forte, Christian Franck, Lindsey K. Stolze, Jayati Chakrabarti, Raul Castro-Portuguez
Publikováno v:
Cell reports
Cell Reports, Vol 35, Iss 13, Pp 109293-(2021)
Cell Reports, Vol 35, Iss 13, Pp 109293-(2021)
SUMMARY While the immediate and transitory response of breast cancer cells to pathological stiffness in their native microenvironment has been well explored, it remains unclear how stiffness-induced phenotypes are maintained over time after cancer ce