Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Adam D Richardson"'
Autor:
Jessica De Ingeniis, Boris Ratnikov, Adam D Richardson, David A Scott, Pedro Aza-Blanc, Surya K De, Marat Kazanov, Maurizio Pellecchia, Ze'ev Ronai, Andrei L Osterman, Jeffrey W Smith
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45190 (2012)
Proline metabolism is linked to hyperprolinemia, schizophrenia, cutis laxa, and cancer. In the latter case, tumor cells tend to rely on proline biosynthesis rather than salvage. Proline is synthesized from either glutamate or ornithine; both are conv
Externí odkaz:
https://doaj.org/article/d83c1930472b4511a15b6ff8fb037355
Autor:
Edward L. LaGory, Colleen Wu, Cullen M. Taniguchi, Chien-Kuang Cornelia Ding, Jen-Tsan Chi, Rie von Eyben, David A. Scott, Adam D. Richardson, Amato J. Giaccia
Publikováno v:
Cell Reports, Vol 12, Iss 1, Pp 116-127 (2015)
Long believed to be a byproduct of malignant transformation, reprogramming of cellular metabolism is now recognized as a driving force in tumorigenesis. In clear cell renal cell carcinoma (ccRCC), frequent activation of HIF signaling induces a metabo
Externí odkaz:
https://doaj.org/article/c95910daf90d42c6b60482a36536d678
Autor:
Matthew H. Cato, Parham Ramezani-Rad, James R. Woodgett, John R Apgar, Cindi Chen, Robert J. Benschop, Julia Jellusova, Adam D. Richardson, Robert C. Rickert, Elaine M Conner, Charlotte R Leung
Publikováno v:
Nature immunology
B cells predominate in a quiescent state until an antigen is encountered, which results in rapid growth, proliferation and differentiation of the B cells. These distinct cell states are probably accompanied by differing metabolic needs, yet little is
Publikováno v:
The British journal of dermatology. 180(6)
Autor:
Nick J. Reynolds, Jason L. Parsons, Kehinde Ross, Adam D. Richardson, Darren W. Sexton, Andrew K. Powell
Publikováno v:
JOURNAL OF CELLULAR PHYSIOLOGY
Extracellular calcium (Ca2+) and store-operated Ca2+ entry (SOCE) govern homeostasis in the mammalian epidermis. Multiple microRNAs (miRNA) also regulate epidermal differentiation, and raised external Ca2+ modulates the expression of several such miR
Autor:
Daniel B. Knorr, Joseph L. Lenhart, Jian Yu, Kevin A. Masser, Erich D. Bain, Adam D. Richardson
Publikováno v:
Journal of Materials Science. 51:2347-2370
Epoxy resins are classically toughened by rubber additives, but the effectiveness of rubber toughening tends to diminish with increasing strain rate, decreasing temperature, and decreasing matrix ductility. In this study, we demonstrate that low load
Autor:
Daniel B. Knorr, Adam D. Richardson, Robert M. Elder, William A. Spurgeon, Jian H. Yu, Mark D. Hindenlang, Timothy W. Sirk, Kevin A. Masser, Joseph L. Lenhart, Steven E. Boyd
Publikováno v:
Composites Science and Technology. 114:17-25
Ballistic performance, at effective strain rates of (10 4 –10 5 s −1 ), for polymeric dicyclopentadiene (pDCPD) was compared with two epoxy resin/diamine systems with comparable glass transition temperatures. The high rate response was characteri
Autor:
Kenneth E. Strawhecker, Daniel B. Knorr, Kevin A. Masser, Jian H. Yu, Adam D. Richardson, Mark D. Hindenlang, Frederick L. Beyer, Joseph L. Lenhart
Publikováno v:
Polymer. 58:96-106
The ballistic performance was examined for a series of broad glass transition temperature epoxy formulations consisting of a di-epoxy monomer crosslinked with bi-modal mixtures of both a rigid, low molecular weight diamine and a flexible, high molecu
Autor:
John Howl, Lewis Muir, Sarah Jones, Sasha Mousdell, Adam D. Richardson, Darren W. Sexton, Kehinde Ross
Publikováno v:
BMC Research Notes
BMC Research Notes, Vol 11, Iss 1, Pp 1-4 (2018)
BMC Research Notes, Vol 11, Iss 1, Pp 1-4 (2018)
Objective Biologically active cell penetrating peptides (CPPs) are an emerging class of therapeutic agent. The wasp venom peptide mastoparan is an established CPP that modulates mitochondrial activity and triggers caspase-dependent apoptosis in cance
Autor:
Priya Prakash Karmali, Immo E. Scheffler, Valentina Fogal, Jeffrey W. Smith, Erkki Ruoslahti, Adam D. Richardson
Publikováno v:
Molecular and cellular biology. 37(14)
p32/gC1qR/C1QBP/HABP1 is a mitochondrial/cell surface protein overexpressed in certain cancer cells. Here we show that knocking down p32 expression in human cancer cells strongly shifts their metabolism from oxidative phosphorylation (OXPHOS) to glyc