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pro vyhledávání: '"Adam D Richard"'
Autor:
Adam D Richard, Xiao-Hong Lu
Publikováno v:
Neural Regeneration Research, Vol 14, Iss 4, Pp 578-581 (2019)
Cognitive decline is a feature of normal and pathological aging. As the proportion of the global aged population continues to grow, it is imperative to understand the molecular and cellular substrates of cognitive aging for therapeutic discovery. Thi
Externí odkaz:
https://doaj.org/article/0e71f365a2304b43ae8bb88afbf187a8
Autor:
Xiao-Hong Lu, Xinli Tian, Aakriti Bhandari, Adam D. Richard, X. William Yang, Nicholas E. Goeders, Ronald Klein, Madison Wynne El-Saadi, Isabella Van Savage, Donard S. Dwyer, Kevlyn Holmes, Brian Latimer
Publikováno v:
Molecular Psychiatry. 24:1884-1901
Recent genome-wide association studies (GWAS) have identified copy number variations (CNVs) at chromosomal locus 7q36.3 that significantly contribute to the risk of schizophrenia, with all of the microduplications occurring within a single gene: vaso
Publikováno v:
Neurobiology of Aging. 71:61-71
Cognitive decline is a feature of aging. Accumulating evidence suggests that the brain extracellular matrix (ECM) is involved in the process of aging-dependent cognitive impairment and neurodegeneration by regulating synaptic neurotransmission and af
Autor:
Ronald Klein, Robert D. Dayton, Mychal S. Grames, Xiao-Hong Lu, Kasey L. Jackson, Adam D. Richard
Publikováno v:
The FASEB Journal. 32:4420-4427
Recombinant adeno-associated virus (AAV) vectors are a popular genetic approach in neuroscience because they confer such efficient transgene expression in the brain and spinal cord. A number of studies have used AAV to express pathological disease-re
Autor:
Lisa M. McDivitt, Richard W. Davis, Vicki A. Nejtek, Christopher Tan, Fredric P. Manfredsson, Blake Blancher, Adam D. Richard, Ella A. Kasanga, Catherine L. Owens, Brandon S. Pruett, Austin Gajewski, Michael F. Salvatore, Mark A. Cantu
Publikováno v:
ACS chemical neuroscience. 10(10)
Glial cell line-derived neurotrophic factor (GDNF) improved motor function in Parkinson's disease (PD) patients in Phase I clinical trials, and these effects persisted months after GDNF discontinuation. Conversely, phase II clinical trials reported n
Autor:
Xiao-Hong Lu, Adam D. Richard
Publikováno v:
Neural Regeneration Research, Vol 14, Iss 4, Pp 578-581 (2019)
Neural Regeneration Research
Neural Regeneration Research
Cognitive decline is a feature of normal and pathological aging. As the proportion of the global aged population continues to grow, it is imperative to understand the molecular and cellular substrates of cognitive aging for therapeutic discovery. Thi
Publikováno v:
2016 32nd Southern Biomedical Engineering Conference (SBEC).
Traditional immunostaining techniques utilize antibodies to probe the expression of specific proteins in the brain, but this only allows for two-dimensional mapping that cannot recapitulate the complex circuit and regional interactions that occur in
Publikováno v:
2016 32nd Southern Biomedical Engineering Conference (SBEC).
Striatum is one of the major components of basal ganglia. More than 90% of principle neurons in striatum are medium spiny neuron (MSN). The MSNs are further subdivided into the direct-pathway (striatonigral or D1) MSNs or the indirect-pathway (striat
Autor:
Xiao-Hong Lu, William Yang, Aakriti Bhandari, Xinli Tian, Nicholas E. Goeders, Adam D. Richard
Publikováno v:
Biological Psychiatry. 83:S215
Autor:
Jessica De Ingeniis, Boris Ratnikov, Adam D Richardson, David A Scott, Pedro Aza-Blanc, Surya K De, Marat Kazanov, Maurizio Pellecchia, Ze'ev Ronai, Andrei L Osterman, Jeffrey W Smith
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45190 (2012)
Proline metabolism is linked to hyperprolinemia, schizophrenia, cutis laxa, and cancer. In the latter case, tumor cells tend to rely on proline biosynthesis rather than salvage. Proline is synthesized from either glutamate or ornithine; both are conv
Externí odkaz:
https://doaj.org/article/d83c1930472b4511a15b6ff8fb037355