Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Adam Cryar"'
Autor:
Ziyue Wang, Adam Cryar, Oliver Lemke, Pinkus Tober-Lau, Daniela Ludwig, Elisa Theresa Helbig, Stefan Hippenstiel, Leif-Erik Sander, Daniel Blake, Catherine S. Lane, Rebekah L. Sayers, Christoph Mueller, Johannes Zeiser, StJohn Townsend, Vadim Demichev, Michael Mülleder, Florian Kurth, Ernestas Sirka, Johannes Hartl, Markus Ralser
Publikováno v:
EClinicalMedicine, Vol 49, Iss , Pp 101495- (2022)
Summary: Background: Global healthcare systems continue to be challenged by the COVID-19 pandemic, and there is a need for clinical assays that can help optimise resource allocation, support treatment decisions, and accelerate the development and eva
Externí odkaz:
https://doaj.org/article/aadb73eb13a34f0391026389c47c46a0
Publikováno v:
Journal of the American Society for Mass Spectrometry. 31:553-564
As monoclonal antibodies (mAbs) rapidly emerge as a dominant class of therapeutics, so does the need for suitable analytical technologies to monitor for changes in protein higher order structure (HOS) of these biomolecules. Reference materials (RM) s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c0e786a8b5232172de6385673a673ff
https://doi.org/10.1021/jasms.9b00022
https://doi.org/10.1021/jasms.9b00022
Autor:
Ziyue Wang, Adam Cryar, Oliver Lemke, Daniela Ludwig, Pinkus Tober-Lau, Elisa Theresa Helbig, Daniel Blake, Catherine S Lane, Rebekah L Sayers, Christoph Mueller, Johannes Zeiser, StJohn Townsend, Vadim Demichev, Michael Mülleder, Florian Kurth, Ernestas Sirka, Johannes Hartl, Markus Ralser
Global healthcare systems continue to be challenged by the COVID-19 pandemic, and there is a need for clinical assays that can both help to optimize resource allocation and accelerate the development and evaluation of new therapies. Here, we present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94f010939d836eabd11ba6e8b263ea0a
https://doi.org/10.1101/2021.12.03.21267253
https://doi.org/10.1101/2021.12.03.21267253
Autor:
Z. Soloviev, E. De Lorenzi, Paul A. Dalby, Bradley B. Stocks, C. Burns, D. Cooper-Shepherd, Altin Sula, V. Wood, Kamila J. Pacholarz, E. Rodriguez, Perdita E. Barran, Kate Groves, Jonathan J. Phillips, L. Luckau, Bonnie A. Wallace, Konstantinos Thalassinos, R. Parakra, S. Hill, P. Vicedo, Raffaella Colombo, J. A. Ferguson, Ryan D. Davis, Alison E. Ashcroft, Adam Cryar, Rosie Upton, Hongyu Zhang, Lorna Ashton, O. Durrant, J.R. Ault, Milena Quaglia
Measurements of protein higher order structure (HOS) provide important information on stability, potency, efficacy, immunogenicity, and biosimilarity of biopharmaceuticals, with a significant number of techniques and methods available to perform thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3e8ca47638ee630d9e7c7c1baab0db7
https://nrc-publications.canada.ca/eng/view/object/?id=d45a403f-088a-4d02-9c14-40c49ef4daaa
https://nrc-publications.canada.ca/eng/view/object/?id=d45a403f-088a-4d02-9c14-40c49ef4daaa
Autor:
Dobril Ivanov, Teresa Niccoli, Linda Partridge, Benjamin Aleyakpo, Inge Snoeren, Daniel K. Fabian, Fiona Kerr, Janet M. Thornton, Oyinkan Sofola-Adesakin, Adam Cryar, Jennifer Adcott
Publikováno v:
Brain Commun
Brain Communications
Brain Communications
Accumulation of amyloid beta peptides is thought to initiate the pathogenesis of Alzheimer's disease. However, the precise mechanisms mediating their neurotoxicity are unclear. Our microarray analyses show that, in Drosophila models of amyloid beta 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::786bea2882571eb2415fc70aaeca055e
https://hdl.handle.net/21.11116/0000-000B-2D76-F
https://hdl.handle.net/21.11116/0000-000B-2D76-F
Publikováno v:
Molecular pharmaceutics. 17(12)
Assuring the stability of therapeutic proteins is a major challenge in the biopharmaceutical industry, and a better molecular understanding of the mechanisms through which formulations influence their stability is an ongoing priority. While the prefe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de5aedae783d7204901e61ed7ee7ceed
https://pubmed.ncbi.nlm.nih.gov/33112626
https://pubmed.ncbi.nlm.nih.gov/33112626
Autor:
Johannes P. C. Vissers, Christine A. Orengo, Konstantinos Thalassinos, David Sutherland, Harry M. Scholes, Lee A. Gethings, Fiona Kerr, Adam Cryar, Jonathan G. Lees, Linda Partridge
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Alzheimer’s disease (AD), the most prevalent form of dementia, is a progressive and devastating neurodegenerative condition for which there are no effective treatments. Understanding the molecular pathology of AD during disease progression may iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f9dc1caaebf4a0f5cd3313c8a9ba30c
http://europepmc.org/articles/PMC7595221
http://europepmc.org/articles/PMC7595221
Publikováno v:
International Journal of Mass Spectrometry. 426:29-37
Ion mobility mass spectrometry (IM-MS) is a fast and sample-efficient method for analysing the gas phase conformation of proteins and protein complexes. Subjecting proteins to increased collision energies prior to ion mobility separation can directly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42893944ec09ca39b1913ee369508785
https://doi.org/10.1016/j.ijms.2018.01.008
https://doi.org/10.1016/j.ijms.2018.01.008
Publikováno v:
Journal of AOAC International. 101:152-161
Assessing the recovery of food allergens from solid processed matrixes is one of the most difficult steps that needs to be overcome to enable the accurate quantification of protein allergens by immunoassay and MS. A feasibility study is described her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ccd2e28e30bc561d5cb8761d29adb0c
https://doi.org/10.5740/jaoacint.17-0214
https://doi.org/10.5740/jaoacint.17-0214
Publikováno v:
Journal of the American Society for Mass Spectrometry
Hydrogen-deuterium exchange mass spectrometry (HDX-MS) is an important tool for measuring and monitoring protein structure. A bottom-up approach to HDX-MS provides peptide level deuterium uptake values and a more refined localization of deuterium inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91b053d936c7caa8f806990cfe5b6ddb
http://europepmc.org/articles/PMC5438439
http://europepmc.org/articles/PMC5438439