Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Adam Ciesiolka"'
Autor:
Vasso Makrantoni, Adam Ciesiolka, Conor Lawless, Josefin Fernius, Adele Marston, David Lydall, Michael J. R. Stark
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 7, Iss 9, Pp 3203-3215 (2017)
The chromosomal passenger complex (CPC) is a key regulator of eukaryotic cell division, consisting of the protein kinase Aurora B/Ipl1 in association with its activator (INCENP/Sli15) and two additional proteins (Survivin/Bir1 and Borealin/Nbl1). Her
Externí odkaz:
https://doaj.org/article/6d523842358f4a3a8279c80c986ab2e2
Autor:
Stephen Gregory Addinall, Eva-Maria Holstein, Conor Lawless, Min Yu, Kaye Chapman, A Peter Banks, Hien-Ping Ngo, Laura Maringele, Morgan Taschuk, Alexander Young, Adam Ciesiolka, Allyson Lurena Lister, Anil Wipat, Darren James Wilkinson, David Lydall
Publikováno v:
PLoS Genetics, Vol 7, Iss 4, p e1001362 (2011)
To better understand telomere biology in budding yeast, we have performed systematic suppressor/enhancer analyses on yeast strains containing a point mutation in the essential telomere capping gene CDC13 (cdc13-1) or containing a null mutation in the
Externí odkaz:
https://doaj.org/article/9b28f9f63e7b434e899130efd26f9f54
Autor:
Adam Ciesiolka, Grzegorz Figura, Katarzyna Rolle, Maciej Borowiec, Bogusław Tymoniuk, Julia Latowska, Paweł Zmora, Agnieszka Fiszer, Adriana Grabowska, Paweł Joachimiak, Luiza Handschuh
Publikováno v:
Przeglad Epidemiologiczny. :14-26
INTRODUCTION. Since the SARS-CoV-2 emergence in 2019/2020, at least 158 million infections with this pathogen have been recorded, of which 3.29 million infected people have died. Due to the non-specific symptoms of SARS-CoV-2 infection, laboratory te
Autor:
Wlodzimierz J. Krzyzosiak, Agata Ciolak, Michał Michalak, Agnieszka Fiszer, Marta Olejniczak, Katarzyna Dorota Raczynska, Dominika Zielinska, Magdalena Wozna-Wysocka, Adam Ciesiolka, Emilia Kozlowska, Magdalena Dabrowska, Paweł Joachimiak, Anna Stroynowska-Czerwinska
Publikováno v:
Cellular and Molecular Life Sciences
Polyglutamine (polyQ) diseases are incurable neurological disorders caused by CAG repeat expansion in the open reading frames (ORFs) of specific genes. This type of mutation in the HTT gene is responsible for Huntington’s disease (HD). CAG repeat-t
Autor:
Magdalena Jazurek-Ciesiolka, Pawel M. Switonski, Maciej Figiel, Agnieszka Fiszer, Paula Sobieszczanska, Dorota Wronka, Lukasz Przybyl, Joanna Suszynska-Zajczyk, Adam Ciesiolka, Grzegorz Figura, Magdalena Wozna-Wysocka, Julia O. Misiorek, Wlodzimierz J. Krzyzosiak
Publikováno v:
B: Models for HD.
Background Experiments with HD mouse models allow for insight into detailed molecular pathways disrupted in the course of disease development. New aspects of HD pathology need to be determined to bring additional targets and hints for therapeutic app
Autor:
Alicja A. Komur, Adam Ciesiolka, Agnieszka Fiszer, Wlodzimierz J. Krzyzosiak, Magdalena Jazurek-Ciesiolka, Martyna Olga Urbanek-Trzeciak
Publikováno v:
Journal of molecular biology. 432(24)
Spinocerebellar ataxia type 3 (SCA3) is a progressive neurodegenerative disorder caused by a CAG repeat expansion in the ATXN3 gene encoding the ataxin-3 protein. Despite extensive research the exact pathogenic mechanisms of SCA3 are still not unders
Autor:
Wlodzimierz J. Krzyzosiak, Adam Ciesiolka, Katarzyna Bilinska, Julia Starega-Roslan, Magdalena Jazurek
Publikováno v:
Nucleic Acids Research
RNA-protein complexes play a central role in the regulation of fundamental cellular processes, such as mRNA splicing, localization, translation and degradation. The misregulation of these interactions can cause a variety of human diseases, including
Autor:
Paweł Joachimiak, Paweł M Świtoński, Emilia Kozlowska, Agata Łużna, Wlodzimierz J. Krzyzosiak, Łukasz Przybył, Magdalena Woźna-Wysocka, Agnieszka Fiszer, Adam Ciesiolka, Magdalena Jazurek-Ciesiolka, Michał Michalak
Publikováno v:
Experimental therapeutics – preclinical.
In development of therapeutic strategy for Huntington’s disease (HD) targeting mutation site directly to inhibit selectively the expression of mutant gene is an attractive option. We have previously described CAG repeat-targeting siRNAs with specif
Autor:
Paweł Joachimiak, Adam Ciesiołka, Emilia Kozłowska, Paweł M. Świtoński, Grzegorz Figura, Agata Ciołak, Grażyna Adamek, Magdalena Surdyka, Żaneta Kalinowska-Pośka, Maciej Figiel, Nicholas S. Caron, Michael R. Hayden, Agnieszka Fiszer
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-16 (2023)
Abstract Background The majority of genes in the human genome is present in two copies but the expression levels of both alleles is not equal. Allelic imbalance is an aspect of gene expression relevant not only in the context of genetic variation, bu
Externí odkaz:
https://doaj.org/article/b4208318decb46dc9b945542e1422b52
Publikováno v:
Frontiers in Cellular Neuroscience
Short Tandem Repeats (STRs) are frequent entities in many transcripts, however, in some cases, pathological events occur when a critical repeat length is reached. This phenomenon is observed in various neurological disorders, such as myotonic dystrop