Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Adam Castoreno"'
Autor:
Maja M. Janas, Mark K. Schlegel, Carole E. Harbison, Vedat O. Yilmaz, Yongfeng Jiang, Rubina Parmar, Ivan Zlatev, Adam Castoreno, Huilei Xu, Svetlana Shulga-Morskaya, Kallanthottathil G. Rajeev, Muthiah Manoharan, Natalie D. Keirstead, Martin A. Maier, Vasant Jadhav
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
A subset of chemically-modified siRNAs conjugated to trivalent GalNAc may fail during nonclinical development due to rat hepatotoxicity. Here, the authors show that hepatotoxicity may be accounted for by microRNA-like off-target effects of siRNA and
Externí odkaz:
https://doaj.org/article/c6e811a8256f42f19ee8c93f99cf1382
Autor:
David A. Barbie, Marina Pasca Di Magliano, Alec C. Kimmelman, Hideo Baba, Kwok K. Wong, Shuji Ogino, Zhirong Qian, Jacob Reibel, Tran Thai, Zehua Zhu, Adam Castoreno, Eiji Oki, Arthur Brannon, Amir Aref, Shunsuke Kitajima, Israel Cañadas, Russell W. Jenkins, Yu Imamura, Shenghong Yang
Supplementary Figure 1. Characterization of inflammatory cell infiltrates and their recovery with time. Supplementary Figure 2. Negative feedback control of pTBK1 by autophagy. Supplementary Figure 3. pTBK1 levels correlate with underlying levels of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20a8f2b3cbf123eaa35b8d7d90e1fb5b
https://doi.org/10.1158/2326-6066.22537418
https://doi.org/10.1158/2326-6066.22537418
Autor:
David A. Barbie, Marina Pasca Di Magliano, Alec C. Kimmelman, Hideo Baba, Kwok K. Wong, Shuji Ogino, Zhirong Qian, Jacob Reibel, Tran Thai, Zehua Zhu, Adam Castoreno, Eiji Oki, Arthur Brannon, Amir Aref, Shunsuke Kitajima, Israel Cañadas, Russell W. Jenkins, Yu Imamura, Shenghong Yang
Autophagy promotes tumor progression downstream of oncogenic KRAS, yet also restrains inflammation and dysplasia through mechanisms that remain incompletely characterized. Understanding the basis of this paradox has important implications for the opt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::125178c448797d45e41158c9e6cb2860
https://doi.org/10.1158/2326-6066.c.6548438.v1
https://doi.org/10.1158/2326-6066.c.6548438.v1
Autor:
Krishna Aluri, Swati Gupta, Sarah Leblanc, Martin Egli, Tim Racie, Muthiah Manoharan, Anna Bisbe, Peter Podbevšek, Vasant Jadhav, John Szeto, Christopher R. Brown, Hartmut Jahns, Ivan Zlatev, Dale C. Guenther, Martin Maier, Pawan Kumar, Adam Castoreno, Janez Plavec, Rohan Degaonkar
Publikováno v:
Nucleic Acids Research
In order to achieve efficient therapeutic post-transcriptional gene-silencing mediated by the RNA interference (RNAi) pathway, small interfering RNAs (siRNAs) must be chemically modified. Several supra-RNA structures, with the potential to stabilize
Autor:
Mark K Schlegel, Maja M Janas, Yongfeng Jiang, Joseph D Barry, Wendell Davis, Saket Agarwal, Daniel Berman, Christopher R Brown, Adam Castoreno, Sarah LeBlanc, Abigail Liebow, Tara Mayo, Stuart Milstein, Tuyen Nguyen, Svetlana Shulga-Morskaya, Sarah Hyde, Sally Schofield, John Szeto, Lauren Blair Woods, Vedat O Yilmaz, Muthiah Manoharan, Martin Egli, Klaus Charissé, Laura Sepp-Lorenzino, Patrick Haslett, Kevin Fitzgerald, Vasant Jadhav, Martin A Maier
Publikováno v:
Nucleic acids research. 50(12)
Preclinical mechanistic studies have pointed towards RNA interference-mediated off-target effects as a major driver of hepatotoxicity for GalNAc–siRNA conjugates. Here, we demonstrate that a single glycol nucleic acid or 2′–5′-RNA modificatio
Autor:
Pawan Kumar, Piet Herdewijn, Joel M. Harp, Ivan Zlatev, Muthiah Manoharan, Marie Capobianco, Martin Egli, Mark K Schlegel, Mikhail Abramov, Maja M. Janas, Charalambos Kaittanis, Yongfeng Jiang, Adam Castoreno, Rohan Degaonkar, Dale C. Guenther, Guy Schepers
Publikováno v:
Nucleic Acids Research
In this report, we investigated the hexopyranose chemical modification Altriol Nucleic Acid (ANA) within small interfering RNA (siRNA) duplexes that were otherwise fully modified with the 2'-deoxy-2'-fluoro and 2'-O-methyl pentofuranose chemical modi
Autor:
Maja M. Janas, Saeho Chong, Mark K Schlegel, Jason Gilbert, Saket Agarwal, Vasant Jadhav, Dale Gunther, Michelle Jung, Mark Keating, Kelly Wassarman, Shigeo Matsuda, Arlin Rogers, Yongfeng Jiang, Lei Johnson, Elena Castellanos-Rizaldos, Jessica E. Sutherland, Scott Lentini, Urjana Poreci, Klaus Charisse, Jing Li, Anne Kasper, Yesseinia Anglero-Rodriguez, Jeff Rollins, Jing-Tao Wu, Alex Kelin, Sarah Le Blanc Sarah Le Blanc, Diana Cha, Martin E. Maier, Adam Castoreno, Samantha Chigas, Tuyen Nguyen, Muthiah Manoharan, Wendell P Davis, Haiyan Peng, Jayaprakash K. Nair, John Petrulis, Christopher S. Theile, Tyler Chickering, Ivan Zlatev, Tim Racie, Kirk Brown, Christopher R. Brown, Stuart Milstein, Jessica Bombardier, Melissa Mobley, Jeffrey Allen, Raj Maganti, Donald Foster, Kevin Fitzgerald, Jeffrey Kurz, Lauren Blair Woods, Robin McDougall
RNA interference (RNAi) therapeutics are a new class of medicines that can address unmet medical needs by silencing disease-causing gene transcripts. While delivery of short interfering RNAs (siRNAs) to hepatocytes has yielded multiple drug approvals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b912cc876215cb4611322852009dc8f
https://doi.org/10.21203/rs.3.rs-946835/v1
https://doi.org/10.21203/rs.3.rs-946835/v1
Autor:
Kirk M. Brown, Jayaprakash K. Nair, Maja M. Janas, Yesseinia I. Anglero-Rodriguez, Lan T. H. Dang, Haiyan Peng, Christopher S. Theile, Elena Castellanos-Rizaldos, Christopher Brown, Donald Foster, Jeffrey Kurz, Jeffrey Allen, Rajanikanth Maganti, Jing Li, Shigeo Matsuda, Matthew Stricos, Tyler Chickering, Michelle Jung, Kelly Wassarman, Jeff Rollins, Lauren Woods, Alex Kelin, Dale C. Guenther, Melissa W. Mobley, John Petrulis, Robin McDougall, Timothy Racie, Jessica Bombardier, Diana Cha, Saket Agarwal, Lei Johnson, Yongfeng Jiang, Scott Lentini, Jason Gilbert, Tuyen Nguyen, Samantha Chigas, Sarah LeBlanc, Urjana Poreci, Anne Kasper, Arlin B. Rogers, Saeho Chong, Wendell Davis, Jessica E. Sutherland, Adam Castoreno, Stuart Milstein, Mark K. Schlegel, Ivan Zlatev, Klaus Charisse, Mark Keating, Muthiah Manoharan, Kevin Fitzgerald, Jing-Tao Wu, Martin A. Maier, Vasant Jadhav
Publikováno v:
Nature biotechnology. 40(10)
Therapeutics based on short interfering RNAs (siRNAs) delivered to hepatocytes have been approved, but new delivery solutions are needed to target additional organs. Here we show that conjugation of 2'-O-hexadecyl (C16) to siRNAs enables safe, potent
Autor:
John Szeto, Adam Castoreno, Muthiah Manoharan, Daniel Berman, Sally Schofield, Klaus Charisse, Christopher R. Brown, Shigeo Matsuda, Joel M. Harp, Mark K Schlegel, Joseph D. Barry, Martin Maier, Martin Egli
Publikováno v:
Nucleic Acids Research
We recently reported that RNAi-mediated off-target effects are important drivers of the hepatotoxicity observed for a subset of GalNAc–siRNA conjugates in rodents, and that these findings could be mitigated by seed-pairing destabilization using a s
Autor:
Akin Akinc, Adam Castoreno, Jingxuan Liu, James Butler, Timothy Racie, Tracy Zimmerman, June Qin, Anna Borodovsky, Martin Maier, Kevin Fitzgerald, Mark K Schlegel
Publikováno v:
RNA. 25:255-263
Hereditary angioedema (HAE) is a genetic disorder mostly caused by mutations in the C1 esterase inhibitor gene (C1INH) that results in poor control of contact pathway activation and excess bradykinin generation. Bradykinin increases vascular permeabi