Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Adam Carie"'
Autor:
Srikumar Chellappan, Said M. Sebti, Nicholas Lawrence, Smitha Pillai, Melanie Carless, Daniele Pernazza, Adam Carie, Piyali Dasgupta, Rebecca Kinkade
Although it is well established that cyclin-dependent kinases phosphorylate and inactivate Rb, the Raf-1 kinase physically interacts with Rb and initiates the phosphorylation cascade early in the cell cycle. We have identified an orally active small
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::018e8ad62fea12338d423af9a78bd2f8
https://doi.org/10.1158/0008-5472.c.6497226
https://doi.org/10.1158/0008-5472.c.6497226
Autor:
Srikumar Chellappan, Said M. Sebti, Nicholas Lawrence, Smitha Pillai, Melanie Carless, Daniele Pernazza, Adam Carie, Piyali Dasgupta, Rebecca Kinkade
Supplementary Figures 1-3 from A Small Molecule Disruptor of Rb/Raf-1 Interaction Inhibits Cell Proliferation, Angiogenesis, and Growth of Human Tumor Xenografts in Nude Mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8cdc920f5e81f5fc1d6a8c3c8e31942
https://doi.org/10.1158/0008-5472.22373844
https://doi.org/10.1158/0008-5472.22373844
Publikováno v:
Cancer Research. 82:5489-5489
Cell line screening of unique compounds can provide mechanistic insights and identify optimal drug combination partners. Bioinformatics analysis of cell screen data and correlation to publicly available datasets can support identification of appropri
Autor:
Kienan Savage, Vijay K. Tiwari, Deborah P. Lavin, Robbie Carson, Jim Pankovich, Adam Carie, Richard D. Kennedy, Sandra Van Schaeybroeck, Shivaali Karelia, Mark Bazett
Publikováno v:
Cancer Research. 81:1183-1183
Background: BRAF mutations (BRAFMT) occur in ∼10-15% of metastatic colorectal cancer (mCRC) and have a poor clinical outcome, in particular those with microsatellite stable (MSS) disease. Anti-BRAF/EGFR combinations have shown some increases in res
Publikováno v:
Biomacromolecules. 18:1874-1884
Described is the development of a polymeric micelle drug delivery platform that addresses the physical property limitations of many nanovectors. The system employs triblock copolymers comprised of a hydrophilic poly(ethylene glycol) (PEG) block, and
Autor:
Tara Lee Costich, Tyler Ellis, J. Edward Semple, Tomas Vojkovsky, Kevin Sill, Taylor Buley, Adam Carie, Brad Sullivan, Suzanne Bakewell
Publikováno v:
Pharmaceutical Nanotechnology. 4:3-15
Autor:
Gary V. Martinez, William Dominguez-Viqueira, J. Edward Semple, Adam Carie, Jyothi Sethuraman, Kevin Sill, Suzanne Bakewell, Bradford Sullivan, Tara Lee Costich
Publikováno v:
Nanomedicine: Nanotechnology, Biology and Medicine.
Nanoparticle drug carriers hold potential to improve current cancer therapy by delivering payload to the tumor environment and decreasing toxic side effects. Challenges in nanotechnology drug delivery include plasma instability, site-specific deliver
Autor:
Taylor Buley, Adam Carie, J. Edward Semple, Bradford Sullivan, Richard Crouse, Suzanne Bakewell, Tara Lee Costich, Kevin Sill, Tyler Ellis
Publikováno v:
Journal of Drug Delivery
Journal of Drug Delivery, Vol 2016 (2016)
Journal of Drug Delivery, Vol 2016 (2016)
Epothilones have demonstrated promising potential for oncology applications but suffer from a narrow therapeutic window. Epothilone D stabilizes microtubules leading to apoptosis, is active against multidrug-resistant cells, and is efficacious in ani
Autor:
Adam Carie, Said M. Sebti
Publikováno v:
Oncogene. 26:3777-3788
A chemical biology approach identifies a beta 2 adrenergic receptor (beta2AR) agonist ARA-211 (Pirbuterol), which causes apoptosis and human tumor regression in animal models. beta2AR stimulation of cAMP formation and protein kinase A (PKA) activatio
Autor:
Eileen Ennis, Said M. Sebti, De An Wang, Rishi K. Jain, Andrew D. Hamilton, Laura Baldini, Huchen Zhou, Adam Carie
Publikováno v:
Org. Biomol. Chem.. 4:2376-2386
Platelet-derived growth factor (PDGF) and its receptor PDGFR are required for tumor growth and angiogenesis, so disruption of the PDGF-PDGFR interaction should lead to starvation of tumors and reduction of tumor growth. Potent PDGF antagonists have b