Zobrazeno 1 - 10
of 169
pro vyhledávání: '"Adam C Straub"'
Autor:
Shuai Yuan, Adam C Straub
Publikováno v:
PLoS ONE, Vol 19, Iss 7, p e0303472 (2024)
Plasmid transfection in cells is widely employed to express exogenous proteins, offering valuable mechanistic insight into their function(s). However, plasmid transfection efficiency in primary vascular endothelial cells (ECs) and smooth muscle cells
Externí odkaz:
https://doaj.org/article/355f42022c5c4e6bbf85b89551e87b39
Autor:
Scott M Emrich, Ryan E Yoast, Xuexin Zhang, Adam J Fike, Yin-Hu Wang, Kristen N Bricker, Anthony Y Tao, Ping Xin, Vonn Walter, Martin T Johnson, Trayambak Pathak, Adam C Straub, Stefan Feske, Ziaur SM Rahman, Mohamed Trebak
Publikováno v:
eLife, Vol 12 (2023)
The essential role of store-operated Ca2+ entry (SOCE) through Ca2+ release-activated Ca2+ (CRAC) channels in T cells is well established. In contrast, the contribution of individual Orai isoforms to SOCE and their downstream signaling functions in B
Externí odkaz:
https://doaj.org/article/5b4624a722da497c9f2661a9b380baec
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Activation of Nrf2, a major transcription factor that drives the antioxidant defense system, is an emerging therapeutic strategy in Sickle Cell Disease (SCD). In this study, transgenic Sickle Cell Anemia mice (SS mice) treated with CDDO-Methyl (CDDO-
Externí odkaz:
https://doaj.org/article/4ad84528c53e42fab1956aea515b9f2e
Autor:
Shuai Yuan, Scott A. Hahn, Megan P. Miller, Subramaniam Sanker, Michael J. Calderon, Mara Sullivan, Atinuke M. Dosunmu-Ogunbi, Marco Fazzari, Yao Li, Michael Reynolds, Katherine C. Wood, Claudette M. St Croix, Donna Stolz, Eugenia Cifuentes-Pagano, Placido Navas, Sruti Shiva, Francisco J. Schopfer, Patrick J. Pagano, Adam C. Straub
Publikováno v:
Redox Biology, Vol 47, Iss , Pp 102166- (2021)
NADPH oxidase 4 (NOX4) regulates endothelial inflammation by producing hydrogen peroxide (H2O2) and to a lesser extent O2•-. The ratio of NOX4-derived H2O2 and O2•- can be altered by coenzyme Q (CoQ) mimics. Therefore, we hypothesize that cytochr
Externí odkaz:
https://doaj.org/article/8dc1b93959bb456aae238a06ad89c79a
Publikováno v:
Annual Review of Physiology. 85:165-189
Resistance arteries and arterioles evolved as specialized blood vessels serving two important functions: ( a) regulating peripheral vascular resistance and blood pressure and ( b) matching oxygen and nutrient delivery to metabolic demands of organs.
Autor:
Dario A. Vitturi, Charles Maynard, Michele Olsufka, Adam C. Straub, Nick Krehel, Peter J. Kudenchuk, Graham Nichol, Michael Sayre, Francis Kim, Cameron Dezfulian
Publikováno v:
Redox Biology, Vol 32, Iss , Pp - (2020)
Brain and heart injury cause most out-of-hospital cardiac arrest deaths but limited pharmacotherapy exists to protect these tissues. Nitrite is a nitric oxide precursor that is protective in pre-clinical models of ischemic injury and safe in Phase I
Externí odkaz:
https://doaj.org/article/01583875712d470e9233c696abea8243
Autor:
Valerian E Kagan, Adam C. Straub, Yulia Y. Tyurina, Alexandr A. Kapralov, Robert Hall, Sally E. Wenzel, Rama Mallampalli, Hülya Bayır
Publikováno v:
Antioxidants & Redox Signaling.
Autor:
Mohammad Iqbal H. Bhuiyan, Cullen B. Young, Israt Jahan, Md Nabiul Hasan, Sydney Fischer, Nur Farah Meor Azlan, Mingjun Liu, Ansuman Chattopadhyay, Huachen Huang, Kristopher T. Kahle, Jinwei Zhang, Samuel M. Poloyac, Bradley J. Molyneaux, Adam C. Straub, Xianming Deng, Delphine Gomez, Dandan Sun
Publikováno v:
Stroke
Background: Worsened stroke outcomes with hypertension comorbidity are insensitive to blood pressure-lowering therapies. In an experimental stroke model with comorbid hypertension, we investigated causal roles of ang II (angiotensin II)–mediated st
Publikováno v:
Redox Biology, Vol 21, Iss , Pp - (2019)
Hemolytic diseases are associated with elevated levels of circulating free heme that can mediate endothelial dysfunction directly via redox reactions with biomolecules or indirectly by upregulating enzymatic sources of reactive species. A key enzymat
Externí odkaz:
https://doaj.org/article/812e4bbad40b41a3bf4fe30007144c28
Autor:
Marta Bueno, Jazmin Calyeca, Timur Khaliullin, Megan P. Miller, Diana Alvarez, Lorena Rosas, Judith Brands, Christian Baker, Amro Nasser, Stephanie Shulkowski, August Mathien, Nneoma Uzoukwu, John Sembrat, Brenton G. Mays, Kaitlin Fiedler, Scott A. Hahn, Sonia R. Salvatore, Francisco J. Schopfer, Mauricio Rojas, Peter Sandner, Adam C. Straub, Ana L. Mora
Publikováno v:
JCI insight, 8(5):e161487. The American Society for Clinical Investigation
Type II alveolar epithelial cell (AECII) redox imbalance contributes to the pathogenesis of idiopathic pulmonary fibrosis (IPF), a deadly disease with limited treatment options. Here, we show that expression of membrane-bound cytochrome B5 reductase