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Akademický článek
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Akademický článek
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Autor:
Michalina Kazek, Lenka Chodáková, Katharina Lehr, Lukáš Strych, Pavla Nedbalová, Ellen McMullen, Adam Bajgar, Stanislav Opekar, Petr Šimek, Martin Moos, Tomáš Doležal
Publikováno v:
PLoS Biology, Vol 22, Iss 5, p e3002299 (2024)
Activation of immune cells requires the remodeling of cell metabolism in order to support immune function. We study these metabolic changes through the infection of Drosophila larvae by parasitoid wasp. The parasitoid egg is neutralized by differenti
Externí odkaz:
https://doaj.org/article/6ea8d92953f143c794e2c9f4f1eac24f
Autor:
Adam Bajgar, Gabriela Krejčová
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Macrophages represent the most functionally versatile cells in the animal body. In addition to recognizing and destroying pathogens, macrophages remove senescent and exhausted cells, promote wound healing, and govern tissue and metabolic homeostasis.
Externí odkaz:
https://doaj.org/article/f004beacc4b54d3da7585ba6644aed85
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Insulin resistance and cachexia represent severe metabolic syndromes accompanying a variety of human pathological states, from life-threatening cancer and sepsis to chronic inflammatory states, such as obesity and autoimmune disorders. Although the o
Externí odkaz:
https://doaj.org/article/6d467b3f48eb471f93c90ec7bda23991
Autor:
Zdenka Bajgarova, Adam Bajgar
Publikováno v:
Brain and Behavior, Vol 10, Iss 2, Pp n/a-n/a (2020)
Abstract Introduction Variance in hypothalamic–pituitary–adrenal (HPA) axis reactivity is considered to be one of the sources of differences in infant temperament. The cortisol enters into interactions with dopamine and serotonin, so it is expect
Externí odkaz:
https://doaj.org/article/8e2cca360a4646ad82d4dde7a09338b5
Autor:
Gabriela Krejčová, Adéla Danielová, Pavla Nedbalová, Michalina Kazek, Lukáš Strych, Geetanjali Chawla, Jason M Tennessen, Jaroslava Lieskovská, Marek Jindra, Tomáš Doležal, Adam Bajgar
Publikováno v:
eLife, Vol 8 (2019)
Macrophage-mediated phagocytosis and cytokine production represent the front lines of resistance to bacterial invaders. A key feature of this pro-inflammatory response in mammals is the complex remodeling of cellular metabolism towards aerobic glycol
Externí odkaz:
https://doaj.org/article/988c82f9ff7246d7af99d3165741a2d1
Autor:
Adam Bajgar, Tomas Dolezal
Publikováno v:
PLoS Pathogens, Vol 14, Iss 4, p e1007022 (2018)
Phagocytosis by hemocytes, Drosophila macrophages, is essential for resistance to Streptococcus pneumoniae in adult flies. Activated macrophages require an increased supply of energy and we show here that a systemic metabolic switch, involving the re
Externí odkaz:
https://doaj.org/article/cb18fdcee8fc4192a13f3d478c3c87d8
Autor:
Adam Bajgar, Katerina Kucerova, Lucie Jonatova, Ales Tomcala, Ivana Schneedorferova, Jan Okrouhlik, Tomas Dolezal
Publikováno v:
PLoS Biology, Vol 13, Iss 4, p e1002135 (2015)
Immune defense is energetically costly, and thus an effective response requires metabolic adaptation of the organism to reallocate energy from storage, growth, and development towards the immune system. We employ the natural infection of Drosophila w
Externí odkaz:
https://doaj.org/article/627e510b24624313ac2237190a4351bb
Publikováno v:
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Insulin resistance and cachexia represent severe metabolic syndromes accompanying a variety of human pathological states, from life-threatening cancer and sepsis to chronic inflammatory states, such as obesity and autoimmune disorders. Although the o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dc20774322cd15a54aa8b0269bdbcf2
https://pubmed.ncbi.nlm.nih.gov/33659253
https://pubmed.ncbi.nlm.nih.gov/33659253